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The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. Zusätzlich bieten wir Ihnen SDHAF1 Antikörper (41) und SDHAF1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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that SDHAF1 contributes to iron-sulfur (Fe-S) cluster incorporation into the Fe-S subunit of CII, SDHB (zeige SDHB ELISA Kits).
Studies indicate that an array of tumor syndromes caused by complex II-associated mutations in genes SDHA, SDHB, SDHC, SDHD, SDHAF1 and SDHAF2 have been identified over a decade.
Leukoencephalopathy with accumulated succinate is a key symptom of defective complex II assembly due to SDHAF1 mutations
Myocardial ischemic reperfusion injury in Sirt5 (zeige SIRT5 ELISA Kits)-/- heart is restored to wild-type levels by pretreatment with dimethyl malonate, a competitive inhibitor of succinate dehydrogenase (SDH (zeige SDHA ELISA Kits)), implicating alteration in SDH (zeige SDS ELISA Kits) activity as causative of the injury.
The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).
succinate dehydrogenase complex assembly factor 1
, succinate dehydrogenase assembly factor 1, mitochondrial
, LYR motif-containing protein 8
, SDH assembly factor 1
, LYR motif containing 8