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Splicing Factor 3b, Subunit 2, 145kDa Proteine (SF3B2)

SF3B2 encodes subunit 2 of the splicing factor 3b protein complex. Zusätzlich bieten wir Ihnen Splicing Factor 3b, Subunit 2, 145kDa Antikörper (54) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Maus SF3B2 SF3B2 319322  
SF3B2 10992 Q13435
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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SF3B2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Weitere Proteine zu Splicing Factor 3b, Subunit 2, 145kDa (SF3B2) Interaktionspartnern

Human Splicing Factor 3b, Subunit 2, 145kDa (SF3B2) Interaktionspartner

  1. a docking model based on NOESY measurements suggests that residues 607-616 of the SF3b145 fragment adopt a helical structure that binds to RRM1 (zeige RRM1 Proteine) predominantly via alpha1, consequently exhibiting a helix-helix interaction in almost antiparallel.

  2. High SF3B2 expression is associated with hepatocellular carcinoma.

  3. Although amino acid substitutions of residues surrounding Arg-508 had no great effect on PRMT9 (zeige FBXO11 Proteine) recognition of SF3B2, moving the arginine residue within this sequence abolished methylation.

  4. Inhibiting the induction of two proteins involved in two of the most significantly upregulated cellular processes, ribosome biogenesis (eIF6 (zeige EIF6 Proteine)) and hnRNA splicing (SF3B2/SF3B4 (zeige SF3B4 Proteine)), showed that human T cells can enter the cell cycle without growing in size.

  5. Data show that Vpr induces checkpoint activation and G(2) arrest by binding to the CUS1 domain of SAP145 and interfering with the functions of the SAP145 and SAP49 (zeige SF3B4 Proteine) proteins, two subunits of the multimeric splicing factor 3b (zeige SF3B14 Proteine) (SF3b).

Splicing Factor 3b, Subunit 2, 145kDa (SF3B2) Protein Überblick

Protein Überblick

This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.

Genbezeichner und Symbole assoziert mit SF3B2

  • splicing factor 3b, subunit 2 (Sf3b2)
  • splicing factor 3b, subunit 2, 145kDa (SF3B2)
  • splicing factor 3b, subunit 2, 145kDa (sf3b2)
  • 145kDa Protein
  • 2610311M13Rik Protein
  • 2810441F20Rik Protein
  • B230398H18Rik Protein
  • Cus1 Protein
  • sap145 Protein
  • SF3b1 Protein
  • SF3B2 Protein
  • SF3B145 Protein
  • sf3b150 Protein

Bezeichner auf Proteinebene für SF3B2

splicing factor 3B subunit 2 , splicing factor 3b, subunit 2, 145kDa , splicing factor 3B subunit 2-like , SAP 145 , pre-mRNA splicing factor SF3b 145 kDa subunit , pre-mRNA-splicing factor SF3b 145 kDa subunit , spliceosome associated protein 145 , spliceosome-associated protein 145

GENE ID SPEZIES
319322 Mus musculus
451343 Pan troglodytes
476015 Canis lupus familiaris
531931 Bos taurus
714747 Macaca mulatta
734465 Xenopus laevis
100052173 Equus caballus
100170589 Xenopus (Silurana) tropicalis
100445486 Pongo abelii
100483831 Ailuropoda melanoleuca
100522004 Sus scrofa
10992 Homo sapiens
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