Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) ELISA Kits

The protein encoded by SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. Zusätzlich bieten wir Ihnen Sphingomyelin phosphodiesterase 1, Acid Lysosomal Antikörper (72) und Sphingomyelin phosphodiesterase 1, Acid Lysosomal Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
SMPD1 6609 P17405
SMPD1 20597 Q04519
SMPD1 308909  
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Top Sphingomyelin phosphodiesterase 1, Acid Lysosomal ELISA Kits auf antikoerper-online.de

Showing 10 out of 34 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.31 ng/mL 1.25-80 ng/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$1,026.67
Details
Maus 0.312-20 ng/mL   96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
$713.90
Details
Meerschweinchen 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Ratte 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Human 0.057 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Anmelden zum Anzeigen 8 bis 12 Tage
$729.25
Details
Kaninchen 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Huhn 4.688 ng/mL 7.813-500 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Affe 0.188 ng/mL 0.313-20 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
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Schwein 0.188 ng/mL 0.313-20 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Hund 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details

Am meisten referenzierte Sphingomyelin phosphodiesterase 1, Acid Lysosomal ELISA Kits

  1. Human SMPD1 ELISA Kit für Sandwich ELISA - ABIN365016 : Zhu, Yoshimoto, Yamashima: Heat shock protein 70.1 (Hsp70.1) affects neuronal cell fate by regulating lysosomal acid sphingomyelinase. in The Journal of biological chemistry 2014 (PubMed)

Weitere ELISA Kits für Sphingomyelin phosphodiesterase 1, Acid Lysosomal Interaktionspartner

Cow (Bovine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Interaktionspartner

  1. results provide evidence that translocated lysosomal V1 H(+)-ATPase (zeige ATP6AP1 ELISA Kits) contributes to formation of local acid microenvironment to facilitate activation of ASM and consequent membrane raft(MR) aggregation, forming MR redox signalosomes and mediating redox signaling in coronary endothelial cells

  2. Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells.

  3. Report lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells.

Human Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Interaktionspartner

  1. Enzyme activities (acid alpha-glucosidase (GAA), galactocerebrosidase (GALC (zeige GALC ELISA Kits)), glucocerebrosidase (GBA (zeige GBA ELISA Kits)), alpha-galactosidase A (GLA (zeige GLA ELISA Kits)), alpha-iduronidase (IDUA (zeige IDUA ELISA Kits)) and sphingomyeline phosphodiesterase-1 (SMPD-1)) were measured on ~43,000 de-identified dried blood spot (DBS (zeige MCF2L ELISA Kits)) punches, and screen positive samples were submitted for DNA sequencing to obtain genotype confirmation of disease risk

  2. This study shows that the ASM alternative splicing pattern could be a biological target with diagnostic relevance and could serve as a novel biomarker for Major depressive disorder

  3. stress-induced activation of p38 MAPK (zeige MAPK14 ELISA Kits) and apoptosis in endothelial cells and established the link between the acid sphingomyelinase/ceramide and p38 MAPK (zeige MAPK14 ELISA Kits) pathways.

  4. Elevated acid sphingomyelinase (ASM) activity in the lung tumor environment and blood serum of patients with non-small cell lung cancer (NSCLC).

  5. this is the largest study on mutation analysis of patients with ASM-deficient Niemann-Pick disease reported in literature and also the first study on the SMPD1 gene mutation spectrum in India.

  6. ASM and ceramides, together with STX6 (zeige STX6 ELISA Kits) and cholesterol, constitute a new regulatory mechanism for the exit of Met from the Golgi during its biosynthetic route.

  7. the p.Ala359Asp mutation causes structural alterations in the hydrophobic environment where ASM is located, decreasing its enzymatic activity

  8. Airway cells with lower SMPD1 activity increases neutrophil chemotaxis towards them.

  9. The results identify acid sphingomyelinase as a novel target of Lycium Chinense berries to decrease saturated/unsaturated fatty acid sphingomyelin ratio, known to be useful for cell health. Consistent with these data, the berries regulate specifically gene expression to protect cells from apoptosis.

  10. ASMase mediated the 50-Hz MF-induced EGFR (zeige EGFR ELISA Kits) clustering via ceramide which was produced from hydrolyzation on lipid rafts

Mouse (Murine) Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Interaktionspartner

  1. The results show that mice lacking acid sphingomyelinase had a significant increase in myelin recovery and a significantly higher oligodendrocyte cell count after 2 weeks remyelination compared to wildtype littermates.

  2. These findings suggest that the paradoxical antidepressant effects of alcohol in depressed organisms are mediated by ASM and its control of sphingolipid homeostasis

  3. this study shows that Asm-deficient mice develop brain measles virus infection that is consistent with an enhanced Treg frequency and/or activity

  4. K8/K18 (zeige KRT18 ELISA Kits)-dependent PKCdelta (zeige PKCd ELISA Kits)- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (zeige KRT18 ELISA Kits) loss.

  5. Aged platelets elicit lung injury in primed recipient mice, which can be alleviated by pharmacological inhibition or genetic deletion of acid sphingomyelinase.

  6. Transgenic ASM female, but not male, mice showed an impaired social preference and a depressive- and anxiogenic-like phenotype, which could be normalized by amitriptyline treatment.

  7. this study shows decreased T cell numbers in Asm-deficient, burn-injured, and microbiota-depleted mice

  8. These findings indicate a novel pathway in tumor metastasis, i.e., tumor cell mediated activation of P-selectin (zeige SELP ELISA Kits) in platelets, followed by activation and secretion of Asm and in turn release of ceramide and tumor metastasis. The data suggest that p38 MAPK (zeige MAPK14 ELISA Kits) acts downstream from P-selectin (zeige SELP ELISA Kits) and is necessary for the secretion of Asm.

  9. Inhibition of ASM in diabetic CACs improved membrane fluidity and homing of these cells to damaged retinal vessels. Collectively, these findings indicate that selective modulation of sphingolipid metabolism in BM-derived cell populations in diabetes normalizes the reparative/proinflammatory cell balance and can be explored as a novel therapeutic strategy for treating diabetic retinopathy.

  10. Inhibition of the smpd1 by antidepressants prevents stress-induced phosphorylation/activation of p38K indicating that antidepressants indirectly target p38K via the acid sphingomyelinase/ceramide system.

Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.

Genbezeichner und Symbole assoziert mit SMPD1

  • sphingomyelin phosphodiesterase (LOC5578088) Antikörper
  • acid sphingomyelinase (ASM) Antikörper
  • acid sphingomyelinase (AFUA_4G06640) Antikörper
  • sphingomyelin phosphodiesterase 1 (SMPD1) Antikörper
  • sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1) Antikörper
  • sphingomyelin phosphodiesterase 1, acid lysosomal (Smpd1) Antikörper
  • sphingomyelin phosphodiesterase 1 (Smpd1) Antikörper
  • A-SMase Antikörper
  • Afu4g06640 Antikörper
  • ASM Antikörper
  • aSMase Antikörper
  • NPD Antikörper
  • SMPD1 Antikörper
  • Zn-SMase Antikörper

Bezeichner auf Proteinebene für SMPD1

sphingomyelin phosphodiesterase , acid sphingomyelinase , sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) , sphingomyelin phosphodiesterase 1, acid lysosomal , sphingomyelin phosphodiesterase 1 , sphingomyelin phosphodiesterase-like , aSMase

GENE ID SPEZIES
5578088 Aedes aegypti
280724 Bos taurus
3509254 Aspergillus fumigatus Af293
450990 Pan troglodytes
711248 Macaca mulatta
100030863 Monodelphis domestica
100172518 Pongo abelii
100307047 Ovis aries
100353898 Oryctolagus cuniculus
100400920 Callithrix jacchus
6609 Homo sapiens
485334 Canis lupus familiaris
505097 Bos taurus
20597 Mus musculus
308909 Rattus norvegicus
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