anti-Speckle-Type POZ Protein (SPOP) Antikörper

SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. Zusätzlich bieten wir Ihnen Speckle-Type POZ Protein Kits (20) und Speckle-Type POZ Protein Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SPOP 8405 O43791
SPOP 20747 Q6ZWS8
SPOP 287643  
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-Speckle-Type POZ Protein Antikörper auf antikoerper-online.de

Showing 10 out of 58 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-SPOP Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC, WB Western Blot: SPOP Antibody [NBP1-33090] - Sample (50 ug of whole cell lysate) A: mouse brain 10% SDS PAGE, antibody diluted at 1:2000. Western Blot: SPOP Antibody [NBP1-33090] - Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE; antibody diluted at 1:1000. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$447.56
Details
Human Kaninchen Unkonjugiert WB SPOP Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the SPOP antibody detected the SPOP protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Huhn Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$433.13
Details
Human Kaninchen Unkonjugiert WB Western Blot: SPOP Antibody [NBP2-20477] - Sample (30 ug of whole cell lysate) A: HCT116 10% SDS PAGE gel, diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
Details
Human Huhn Unkonjugiert WB 0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
Details
Human Huhn Unkonjugiert WB 0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
Details
Human Kaninchen Unkonjugiert WB SPOP antibody used at 0.2-1 ug/ml to detect target protein. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$473.93
Details

SPOP Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human ,
, ,
,
, , , , , , , , , , , , , , , ,
Mouse (Murine) ,
,

, , , , , , , , , , , , ,
Rat (Rattus) ,
,

, , , , , , , , , , , , ,

Weitere Antikörper gegen Speckle-Type POZ Protein Interaktionspartner

Xenopus laevis Speckle-Type POZ Protein (SPOP) Interaktionspartner

  1. Dzip1 (zeige DZIP1 Antikörper)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (zeige GLI1 Antikörper)/Ci proteins in the Hh pathway.

Human Speckle-Type POZ Protein (SPOP) Interaktionspartner

  1. methylation status of SPOP promoter can be used as a novel epigenetic biomarker and a therapeutic target in colorectal cancer.

  2. these data highlight SPOP as an important regulator of luminal epithelial cell proliferation and c-MYC (zeige MYC Antikörper) expression in prostate physiology, identify c-MYC (zeige MYC Antikörper) as a novel bona fide SPOP substrate, and help explain the frequent inactivation of SPOP in human prostate adenocarcinoma.

  3. Results elucidate the tumor-suppressor role of SPOP in prostate cancer in which it acts as a negative regulator of BET protein stability and also provide a molecular mechanism for resistance to BET inhibitors in individuals with prostate cancer bearing SPOP mutations.

  4. SPOP mutation in endometrial cancer increased degradation of BRD2 (zeige BRD2 Antikörper), BRD3 (zeige BRD3 Antikörper) and BRD4 (zeige BRD4 Antikörper) proteins. SPOP mutation in prostate cancer increased expression of BRD2 (zeige BRD2 Antikörper), BRD3 (zeige BRD3 Antikörper) and BRD4 (zeige BRD4 Antikörper) proteins.

  5. Prostate cancer-derived SPOP mutants failed to interact with Cdc20 (zeige CDC20 Antikörper) to promote its degradation. As a result, SPOP-deficient prostate cancer cells with elevated Cdc20 (zeige CDC20 Antikörper) expression became resistant to a pharmacological Cdc20 (zeige CDC20 Antikörper) inhibitor.

  6. While wild-type SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutants have a diffuse distribution in the nucleus. SPOP oligomerizes through its BTB and BACK domains.

  7. SPOP mutation activates both PI3K (zeige PIK3CA Antikörper)/mTOR (zeige FRAP1 Antikörper) and androgen receptor (zeige AR Antikörper) signaling, effectively uncoupling the normal negative feedback between these two pathways.

  8. SPOP-containing complex regulates SETD2 (zeige SETD2 Antikörper) stability and H3K36me3-coupled alternative splicing.

  9. The levels of SPOP significantly decreased, while the levels of SIRT2 (zeige SIRT2 Antikörper) significantly increased in non-small cell lung cancer (NSCLC) cell lines, compared to normal bronchial epithelial cell line and NSCLC specimens, compared to the paired non-tumor lung tissue.

  10. hese findings reveal novel molecular events underlying the regulation of INF2 (zeige INF2 Antikörper) function and localization, and provided insights in understanding the relationship between SPOP mutations and dysregulation of mitochondrial dynamics in prostate cancer.

Mouse (Murine) Speckle-Type POZ Protein (SPOP) Interaktionspartner

  1. Speckle-type pox virus and zinc finger (POZ) protein (SPOP) regulates endometrial stromal cell decidualization in mice and that hormones regulate the expression of SPOP. This study suggests that ubiquitination may be involved in embryonic implantation.

  2. These results implicate SPOP as a novel participant in DNA double strand break repair and suggest that SPOP mutation drives prostate tumorigenesis in part through genomic instability.

  3. miR (zeige MLXIP Antikörper)-145 has a role in post-transcriptional regulation of SPOP expression in selected tissues.

  4. Dzip1 (zeige DZIP1 Antikörper)-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (zeige GLI1 Antikörper)/Ci proteins in the Hh pathway.

  5. similar S/T-rich motifs are present in Gli (zeige GLI1 Antikörper) proteins as well as in numerous HIB-interacting proteins and mediate Gli (zeige GLI1 Antikörper) degradation by SPOP

  6. MacroH2A1.2 (zeige H2AFY Antikörper) binds the nuclear protein Spop.

  7. Interaction of endogenous PDX-1 (zeige PDX1 Antikörper) and PCIF1 in MIN6 insulinoma (zeige RPS15 Antikörper) cells, is demonstarted.

Speckle-Type POZ Protein (SPOP) Antigen-Profil

Protein Überblick

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

Genbezeichner und Symbole assoziert mit SPOP

  • speckle type POZ protein (spop) Antikörper
  • speckle type BTB/POZ protein (SPOP) Antikörper
  • Speckle-type POZ protein (Bm1_45730) Antikörper
  • speckle-type POZ protein (spop) Antikörper
  • speckle type POZ protein S homeolog (spop.S) Antikörper
  • speckle-type POZ protein (Spop) Antikörper
  • speckle type BTB/POZ protein (Spop) Antikörper
  • AI315626 Antikörper
  • BTBD32 Antikörper
  • Pcif1 Antikörper
  • spop Antikörper
  • TEF2 Antikörper
  • zgc:64140 Antikörper

Bezeichner auf Proteinebene für SPOP

speckle-type POZ protein , Speckle-type POZ protein , speckle-type POZ protein-like , HIB homolog 1 , SPOP1 , speckle-type POZ protein B , roadkill homolog 1 , PDX-1 C-terminal-interacting factor 1

GENE ID SPEZIES
394599 Xenopus (Silurana) tropicalis
455106 Pan troglodytes
699711 Macaca mulatta
6104034 Brugia malayi
100390371 Callithrix jacchus
100021911 Monodelphis domestica
100056116 Equus caballus
100195374 Salmo salar
100544737 Meleagris gallopavo
100587478 Nomascus leucogenys
100005514 Danio rerio
779391 Xenopus laevis
425528 Gallus gallus
8405 Homo sapiens
480548 Canis lupus familiaris
530618 Bos taurus
20747 Mus musculus
287643 Rattus norvegicus
100343929 Oryctolagus cuniculus
100713182 Cavia porcellus
101111300 Ovis aries
100173908 Pongo abelii
Ausgewählte Anbieter für anti-Speckle-Type POZ Protein (SPOP) Antikörper
Haben Sie etwas anderes gesucht?