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SP7 encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Zusätzlich bieten wir Ihnen SP7 Kits (26) und SP7 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 37 products:
Human Polyclonal SP7 Primary Antibody für IF (p), IHC (p) - ABIN737811
Chen, Lazarenko, Zhang, Blackburn, Ronis, Badger: Diet-derived phenolic acids regulate osteoblast and adipocyte lineage commitment and differentiation in young mice. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014
Show all 11 Pubmed References
Cow (Bovine) Polyclonal SP7 Primary Antibody für IHC, WB - ABIN2777381
Milona, Gough, Edgar: Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. in BMC genomics 2004
TP(thymidine phosphorylase (zeige TYMP Antikörper) ) curbed the expression of three proteins-IRF8 (zeige IRF8 Antikörper), RUNX2 (zeige RUNX2 Antikörper), and osterix. This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling and increased the methyltransferase DNMT3A's expression
dissection of these interconnected epigenetic mechanisms that govern Sp7 gene activation reveals a hierarchical process where regulatory components mediating DNA demethylation play a leading role
SP7 gene promoter is robustly enriched in epigenetic repressive marks that may explain its poor transcriptional response to osteoblast differentiating media in umbilical cord derived mesenchymal stem cells.
Eight and five of the nine samples were negative for cell adhesion molecule 1 (zeige CADM1 Antikörper) and Osterix respectively. The other markers showed no statistical significance(CD151 (zeige CD151 Antikörper),ALP (zeige ALP Antikörper)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 (zeige CADM1 Antikörper) could be a useful marker for identifying this phenomenon in carcinoma tissues
The results suggest that Osterix plays an important role in increasing BMP- 4 (zeige BMP4 Antikörper)-induced Cx43 (zeige GJA1 Antikörper) activity.
The expression of specific targets Smad1 (zeige GARS Antikörper) and Osterix was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (zeige MUC7 Antikörper)+). As miR (zeige MLXIP Antikörper)-30b, miR (zeige MLXIP Antikörper)-133a, and miR (zeige MLXIP Antikörper)-143 are negatively regulated by Pi and restored by Mg(2 (zeige MUC7 Antikörper)+) with a congruent modulation of their known targets Runx2 (zeige RUNX2 Antikörper), Smad1 (zeige GARS Antikörper), and Osterix, our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (zeige RUNX2 Antikörper)-Osterix-BSP (zeige KLK6 Antikörper) Signaling.
Osx (zeige MID1 Antikörper) might function as a potential regulator for the proliferation and odontoblastic differentiation of hDPCs.
Data suggest that beta-catenin (beta-cat) signaling upregulates the expression of osterix (OSX) in pre-osteoblastic and bone marrow stromal cells.
The 2 genes RUNX1 (zeige RUNX1 Antikörper) and SP7 resulted differently expressed in cells cultured on metallic supports if compared with the expression recorded for OIC
Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth
FGF and Wnt (zeige WNT2 Antikörper)/beta-Catenin (zeige CTNNB1 Antikörper) pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.
Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.
These results suggest proliferation and maturation of immature osteoblasts requires Tgfbr2 (zeige TGFBR2 Antikörper) signaling and that decreased bone volume in Osx-Cre;Tgfbr2 (zeige TGFBR2 Antikörper)(fl/fl (zeige FLT3LG Antikörper)) mice is likely due to fewer mature osteoblasts.
DNA damage and senescence in osteoprogenitors expressing Osx may cause their decrease with age.
The data support a model in which Dlx recruitment of Sp7 to osteoblast enhancers underlies Sp7-directed osteoblast specification.
Mmp13 (zeige MMP13 Antikörper) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (zeige PTH Antikörper), and Osterix through distal enhancers.
These results indicated that olfactory bulb development was not significantly impaired in the absence of Osx.
Wnt3a (zeige WNT3A Antikörper) induces Osx expression via p38 MAPK (zeige MAPK14 Antikörper) signaling in dental follicle cells. Wnt3a (zeige WNT3A Antikörper)-induced Osx expression was inhibited in the presence of p38 mitogen-activated protein kinase (zeige MAPK14 Antikörper) (MAPK (zeige MAPK1 Antikörper)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.
Transfection assay demonstrated that Osx was able to activate Bsp (zeige KLK6 Antikörper) promoter reporter in a dose-dependent manner. To define minimal region of Bsp (zeige KLK6 Antikörper) promoter activated by Osx, a series of deletion mutants of Bsp (zeige KLK6 Antikörper) promoter were generated, and the minimal region was narrowed down to the proximal 100 bp. Point-mutagenesis studies showed that one GC-rich (zeige RELB Antikörper) site was required for Bsp (zeige KLK6 Antikörper) promoter activation by Osx.
OSX served a key role in the development and progression of ALD (zeige ABCD1 Antikörper)-induced VSMC calcification. This observation may aid in the explanation of the role of OSX in the pathogenesis of vascular calcification
results suggest that expression of Sp7 during the early stage of Satb2 (zeige SATB2 Antikörper)-induced osteogenic differentiation of BMSCs is regulated by miR (zeige MLXIP Antikörper)-27a.
Fibrillin-2 (zeige FBN2 Antikörper) and periostin (zeige POSTN Antikörper) are target genes in Osterix-mediated osteoblast differentiation.
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
transcription factor Sp7
, zinc finger protein osterix
, transcription factor osterix
, Sp7 transcription factor
, transcription factor Sp7-like
, trans-acting transcription factor 7
, Sp7 transcription factor 7