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SLCO1B3 encodes a liver-specific member of the organic anion transporter family. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal SLCO1B3 Primary Antibody für ICC, IF - ABIN261578
Cui, König, Nies, Pfannschmidt, Hergt, Franke, Alt, Moll, Keppler: Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. in Laboratory investigation; a journal of technical methods and pathology 2003
Show all 12 Pubmed References
OATP1B3 protein expression starts at a very high expression level throughout the neonatal phase, thereafter declining in the early childhood years. Then protein expression starts to increase again during the preadolescent period.
High transcript levels of OATP1B3, but not OATP1B1 (zeige SLCO1B1 Antikörper) were observed in isolated human adult islets. While OATP1B3 protein expression was variable, the carrier co-localized more frequently with glucagon (zeige GCG Antikörper)-positive alpha cells than insulin (zeige INS Antikörper)-positive beta cells in islets of normal pancreatic tissues from ten subjects using dual immunostaining.
the current studies for the first time report ubiquitination of OATP1B1 (zeige SLCO1B1 Antikörper) and OATP1B3 and the apparent substrate-dependent inhibitory effect of bortezomib on OATP1B3-mediated transport. The data suggest that bortezomib has a low risk of causing OATP (zeige SLCO1A2 Antikörper)-mediated DDIs
Study showed that the multi-specific liver transporter OATP1B3 can form homo-oligomers and can interact with other transporters in the liver, including OATP1B1 (zeige SLCO1B1 Antikörper) and NTCP (zeige SLC10A1 Antikörper). We also demonstrated that the homo-oligomers work as two or more individual functional subunits.
Our results did not indicate a strong association between OATP1B1 (zeige SLCO1B1 Antikörper) or OATP1B3 inhibition and hyperbilirubinemia
SLCO1B3 was significantly downregulated in docetaxel-resistant patient-derived prostatic tumours xenografted into mice. SLCO1B3 determines intracellular concentrations of docetaxel and cabazitaxel and consequently influences taxane efficacy. Loss of the drug transporter SLCO1B3 may drive taxane resistance in prostate cancer.
transport of CPR (zeige POR Antikörper) I mediated by OATP1B1 (zeige SLCO1B1 Antikörper) and OATP1B3 and the transport of CPR (zeige POR Antikörper) III mediated by OATPs 1B1, 1B3 and 2B1 (zeige SPI1 Antikörper) is time-dependent, can be saturated and inhibited
Our results indicated that OATP1B3 may play an important role in the transport of glycocholic acid and glycochenodeoxycholic acid in the human placenta.
Results identified interethnic differences of genetic variations of the SLCO1B1 (zeige SLCO1B1 Antikörper), SLCO1B3, and SLCO2B1 (zeige SLCO2B1 Antikörper) genes in Korean population compared with other ethnic groups.
OATP1B1 (zeige SLCO1B1 Antikörper)- and OATP1B3-humanized mice can be used as in vivo tools to assess and possibly predict clinically relevant DDIs.
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia.
organic anion transporting polypeptide C
, organic anion transporting polypeptide 1b4
, solute carrier organic anion transporter family, member 1B3
, solute carrier organic anion transporter family member 1B3
, organic anion transporting polypeptide 1b3
, solute carrier organic anion transporter family member 1B3-like
, liver-specific organic anion transporter 2
, liver-specific organic anion transporter 3TM13
, organic anion transporter 8
, organic anion transporter LST-3c
, organic anion-transporting polypeptide 8
, solute carrier family 21 (organic anion transporter), member 8