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SLCO1B1 encodes a liver-specific member of the organic anion transporter family. Zusätzlich bieten wir Ihnen SLCO1B1 Antikörper (40) und viele weitere Produktgruppen zu diesem Protein an.
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OATP1B1 showed high interindividual variability in relative protein expression but no statistically significant difference among the studied age groups.
SLCO1B1*5 allele variants and patient age predict the likelihood of young women with breast cancer developing chemotherapy-induced amenorrhea.
SLCO1B1 polymorphisms appear to be associated with the development of adverse drug reactions to regorafenib.
Polymorphisms in SLCO1B1 and UGT1A1 (zeige UGT1A1 Proteine) are associated with several different sorafenib side effects
OATP1A2, OATP1B1, and OATP2B1 (zeige SLCO2B1 Proteine) can mediate cellular uptake of ochratoxin A, which could aggravate OTA toxicity.
Our results did not indicate a strong association between OATP1B1 or OATP1B3 inhibition and hyperbilirubinemia
Polymorphisms of the SLCO1B1 gene ate used for predicting risk of adverse events when using statins.
Critical amino acid residues in the predicted transmembrane pore influencing transport kinetics of the hepatic drug transporter OATP1B1 have been identified.
Genetic polymorphisms of the UGT1A1 (zeige UGT1A1 Proteine) promoter, specifically the T-3279G phenobarbital-responsive enhancer module and (TA)7 dinucleotide repeat, as well as the intron and coding region variants of the OATP2, HMOX1 (zeige HMOX1 Proteine), and BLVRA (zeige BLVRA Proteine) genes, were significantly higher among the cases than the controls.
SLCO1B1 genotype was not associated with the risk of statin-associated muscle symptoms.
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.
, liver-specific organic anion transporter 1
, sodium-independent organic anion-transporting polypeptide 2
, solute carrier family 21 (organic anion transporter), member 6
, solute carrier family 21 member 6
, solute carrier organic anion transporter family member 1B1
, solute carrier organic anion transporter family, member 1B1
, solute carrier organic anion transporter family member 1B1-like