anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) Antikörper

The protein encoded by SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Zusätzlich bieten wir Ihnen Sodium Channel, Voltage-Gated, Type V, alpha Subunit Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SCN5A 20271 Q9JJV9
SCN5A 6331 Q14524
SCN5A 25665 P15389
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Top anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit Antikörper auf antikoerper-online.de

Showing 10 out of 109 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-SCN5A Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>SW620 cell lysate Host: Rabbit <br /> Target Name: SCN5A <br /> Sample Tissue: MCF7 Whole Cell <br /> Lane A:  Primary Antibody Lane B: Primary Antibody + Blocking Peptide <br />Primary Antibody Concentration: 1 µg/mL Peptide Concentration: 5 µg/mL Lysate Quantity: 41 µg/lane/LaneGel Concentration:.12 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-SCN5A Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>Human Muscle 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB Rabbit Anti-SCN5A Antibody  Catalog Number: ARP34935_P050 Formalin Fixed Paraffin Embedded Tissue: Human Adult heart  Observed Staining: Membrane (stronger than with ARP34934) Primary Antibody Concentration: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 – 2.0 sec Protocol located in Reviews and Data. WB Suggested Anti-SCN5A Antibody Titration: HEK cel lysate; HEK cel with HuNav1.5 transfected lysate; Mouse Heart lysate80 ug protein on gelQC Antibodies 1:100 in PBS/Tweensecondary antibodie 1:10.000 ( IRDYE 800 CWGoat anti Rabbit IgG) analyse with the Licor Odyssey Positive Control: HEK cel lysate; HEK cel with HuNav1.5 transfected lysate; Mouse Heart lysate80 ug protein on gelQC Antibodies 1:100 in PBS/Tweensecondary antibodie 1:10.000 ( IRDYE 800 CWGoat anti Rabbit IgG) analyse with the Licor Odyssey 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Ziege Unkonjugiert ELISA, IHC, IHC (p) Western Blot: Nav1.5 Antibody [ABIN269816] - Rat Brain lysate . Immunohistochemistry-Paraffin: Nav1.5 Antibody [ABIN269816] - Mouse Brain. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$317.63
Details
Maus Kaninchen Unkonjugiert WB   100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Hund Kaninchen Unkonjugiert IHC (p) Anti-SCN5A / Nav1.5 antibody  ABIN1049322 IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$221.76
Details
Human Kaninchen Unkonjugiert WB SCN5A Antibody (N-term)  western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the SCN5A antibody detected the SCN5A protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Ziege Unkonjugiert IHC (p), ELISA Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with SCN5A antibody ABIN290512 at 5-10 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details

SCN5A Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine) , ,
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Rat (Rattus) , ,
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Am meisten referenzierte anti-Sodium Channel, Voltage-Gated, Type V, alpha Subunit Antikörper

  1. Cow (Bovine) Polyclonal SCN5A Primary Antibody für WB - ABIN2776347 : Shah, Wingo, Weiss, Williams, Balser, Chazin: Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 5 Pubmed References

  2. Cow (Bovine) Polyclonal SCN5A Primary Antibody für ELISA, IHC - ABIN269816 : Olson, Michels, Ballew, Reyna, Karst, Herron, Horton, Rodeheffer, Anderson: Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. in JAMA 2005 (PubMed)

  3. Cow (Bovine) Polyclonal SCN5A Primary Antibody für IHC, WB - ABIN2776088 : Van Norstrand, Tester, Ackerman: Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome. in Heart rhythm : the official journal of the Heart Rhythm Society 2008 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen Sodium Channel, Voltage-Gated, Type V, alpha Subunit Interaktionspartner

Mouse (Murine) Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) Interaktionspartner

  1. identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13 (zeige FGF13 Antikörper)-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts.

  2. Enhanced A-V conduction in mice overexpressing SCN5A in the heart mimics the human syndrome of Enhanced Atrioventricular Nodal Conduction .

  3. Loss of the C-terminus of connexin43 (zeige GJA1 Antikörper) limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.

  4. Ser571-mediated increases in INa (zeige INA Antikörper),L promote abnormal repolarization and intracellular Ca(2 (zeige CA2 Antikörper)+) handling and increase susceptibility to arrhythmia. Ser571 is required for maladaptive remodeling and arrhythmias in response to pressure overload.

  5. intracellular Ca(2 (zeige CA2 Antikörper)+) contributes to the regulation of INaL conducted by NaV1.5 mutants and propose that, during excitation-contraction coupling, elevated intracellular Ca(2 (zeige CA2 Antikörper)+) suppresses mutant channel INaL and protects cells from delayed repolarization.

  6. Results show that Nav1.5 upregulation correlates with disease severity in monophasic and chronic-relapsing experimental autoimmune encephalomyelitis and that Nav1.5 expression in astrocytes is modulated in parallel with periods of disease and remission

  7. FoxO1 (zeige FOXO1 Antikörper) is involved in the modulation of NaV1.5 expression in ischemic heart disease.

  8. Our results suggested that the main expression subtype of sodium channels was Nav1.5 of early embryonic cardiomyocytes.

  9. Data indicate that reduction in connexin43 (Cx43 (zeige GJA1 Antikörper)) and sodium channel NaV1.5 expression coincided with overexpression of transgene calcineurin A (CnA (zeige CAN Antikörper)) and hypertrophy development and preceded significant presence of fibrosis.

  10. Expression of NaV1.5 in cardiomyocytes is regulated by the PDZ domain (zeige INADL Antikörper)-binding motif.

Human Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) Interaktionspartner

  1. identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13 (zeige FGF13 Antikörper)-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts.

  2. Pathogenic variants in the SCN5A gene modify electrical excitability of sodium cannel that causes an imbalance in the currents of the different ions involved in the contraction process of the cardiomyocytes and induce ventricular remodeling and Dilated cardiomyopathy.

  3. Almost 2% of ARVD (zeige TGFB3 Antikörper)/C patients harbour rare SCN5A variants. For one of these variants, we demonstrated reduced sodium current, Nav1.5 and N-Cadherin (zeige CDH2 Antikörper) clusters at junctional sites. This suggests that Nav1.5 is in a functional complex with adhesion molecules, and reveals potential non-canonical mechanisms by which Nav1.5 dysfunction causes cardiomyopathy.

  4. The SCN5A variants R568H and A993T can be classified as pathogenic LQTS3 causing mutations.

  5. Brugada syndrome patients with SCN5A mutations exhibit more conduction abnormalities on ECG.

  6. One common intronic variant in SCN5A is linked with risk of Ventricular Fibrillation caused by first ST-Segment Elevation Myocardial Infarction.

  7. Nav1.5 is hyperacetylated on K1479 in the hearts of patients with cardiomyopathy and clinical conduction disease.

  8. BIMU8 is a potent blocker of hERG (zeige KCNH2 Antikörper), NaV1.5 and CaV1.2 (zeige CACNA1C Antikörper) cardiac ion channels, inducing cardiac arrhythmias.

  9. It might be important to suspect the coexistence of DCM and LQT3 (which is rare according to previous articles) in cases with this novel SCN5A missense mutation

  10. Mutational analysis across all 29 exons in SCN5A of the proband and first-degree relatives of the family revealed that the proband inherited a compound heterozygote mutation in SCN5A, specifically p.A226V and p.R1629X from each parent. The study is the first to report a SCN5A compound heterozygote in a Singaporean Chinese family.

Rabbit Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) Interaktionspartner

  1. Freshly dispersed rabbit airway smooth muscle cells express a fast voltage-gated Na(+) current that is mediated mainly by the NaV1.5 subtype.

  2. Mechanisms are determined by a two-dimensional slice model at single-cell and tissue levels in order to determine that SCN5A mutations impair cardiac pacemaking.

Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A) Antigen-Profil

Protein Überblick

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit SCN5A

  • sodium voltage-gated channel alpha subunit 5 (SCN5A) Antikörper
  • sodium channel, voltage-gated, type V, alpha (Scn5a) Antikörper
  • sodium voltage-gated channel alpha subunit 5 (Scn5a) Antikörper
  • CDCD2 Antikörper
  • CMD1E Antikörper
  • CMPD2 Antikörper
  • HB1 Antikörper
  • HB2 Antikörper
  • HBBD Antikörper
  • HH1 Antikörper
  • ICCD Antikörper
  • IVF Antikörper
  • LQT3 Antikörper
  • mH1 Antikörper
  • Nav1.5 Antikörper
  • Nav1.5c Antikörper
  • PFHB1 Antikörper
  • SCAL Antikörper
  • SkM1 Antikörper
  • SkM2 Antikörper
  • SSS1 Antikörper
  • VF1 Antikörper

Bezeichner auf Proteinebene für SCN5A

sodium channel, voltage-gated, type V, alpha subunit , voltage-gated sodium channel type V alpha , sodium channel protein type 5 subunit alpha , voltage-gated sodium channel cardiac isoform Nav1.5 , sodium channel protein cardiac muscle subunit alpha , sodium channel protein type V subunit alpha , sodium channel voltage-gated type V alpha polypeptide , sodium channel, voltage-gated, type V, alpha polypeptide , voltage-gated sodium channel subunit alpha Nav1.5 , cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit , cardiac sodium channel , sodium channel alpha subunit , sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) , voltage-gated sodium channel alpha subunit , sodium channel, voltage-gated, type V, alpha polypeptide (long (electrocardiographic) QT syndrome 3) , sodium channel, voltage-gated, type 5, alpha subunit , voltage-gated sodium channel Nav1.5c , oltage-gated sodium channel type V alpha , voltage-dependent sodium channel SCN10A , voltage-gated sodium channel H , voltage-gated sodium channel type V alpha polypeptide

GENE ID SPEZIES
747523 Pan troglodytes
100034027 Equus caballus
20271 Mus musculus
6331 Homo sapiens
403497 Canis lupus familiaris
282061 Bos taurus
25665 Rattus norvegicus
395947 Gallus gallus
100009516 Oryctolagus cuniculus
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