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Sirtuin 3 Proteine (SIRT3)

SIRT3 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen SIRT3 Antikörper (231) und SIRT3 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIRT3 23410 Q9NTG7
SIRT3 64384 Q8R104
SIRT3 293615  
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Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 11 bis 15 Tage
303,81 €
Details
HOST_Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
667,62 €
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
533,33 €
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
218,90 €
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 6 bis 8 Tage
348,23 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 6 bis 8 Tage
356,80 €
Details
HOST_Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
624,76 €
Details
HOST_Escherichia coli (E. coli) Huhn Unkonjugiert   5 applications Anmelden zum Anzeigen 5 bis 7 Tage
324,01 €
Details
HOST_Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
844,64 €
Details

SIRT3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Am meisten referenzierte SIRT3 Proteine

  1. Human SIRT3 Protein expressed in Escherichia coli (E. coli) - ABIN667166 : Schwer, North, Frye, Ott, Verdin: The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. in The Journal of cell biology 2002 (PubMed)
    Zeige alle 2 Referenzen für ABIN667166

  2. Human SIRT3 Protein expressed in Wheat germ - ABIN1320045 : Pacella-Ince, Zander-Fox, Lan: Mitochondrial SIRT3 and its target glutamate dehydrogenase are altered in follicular cells of women with reduced ovarian reserve or advanced maternal age. in Human reproduction (Oxford, England) 2014 (PubMed)

Weitere Proteine zu Sirtuin 3 (SIRT3) Interaktionspartnern

Human Sirtuin 3 (SIRT3) Interaktionspartner

  1. SIRT3 promotes the malignancy of non-small cell lung cancer, showing an oncogenic preference towards squamous cell carcinoma, and that could represent a novel target for treatment.

  2. These data demonstrate a critical role of SIRT3 in the control of myofibroblast differentiation and lung fibrosis.

  3. this article indicates a novel functional interplay between estrogen receptor beta (zeige ESR2 Proteine) and sirtuin-3 counteracting reactive oxygen species production in TCam-2 cells. Our findings thus show that an important tumor-suppressive pathway through estrogen receptor beta (zeige ESR2 Proteine) is target of E2, actually proposing a distinctive protecting action against seminoma.

  4. Hence, we conclude that SIRT3 exhibits neuroprotection via deacetylating and increasing mitochondrial enzyme activities.

  5. In conclusion, our data suggest that Sirt3 overexpression antagonize high glucose-induced apoptosis by controlling ROS (zeige ROS1 Proteine) accumulation and ROS (zeige ROS1 Proteine)-sensitive Akt (zeige AKT1 Proteine)/FoxO (zeige FOXO3 Proteine) signaling pathway in HK-2 (zeige HK2 Proteine) cells.

  6. These results suggest that Sirt3 may inhibit retinal neovascularization by regulating the migration-, neovascularization- and autophagy-related factors expression. Thus we argue that Sirt3 may be a potential candidate drug for curing various eye diseases induced by retinal neovascularization.

  7. cells with low SIRT1 (zeige SIRT1 Proteine) levels can maintain their resistance and survival by increasing SIRT3 expression.

  8. Our findings suggest that Sirt3 plays a tumor-progressive role in human RCC by regulating glutamine-derived mitochondrial respiration, particularly in cells where mitochondrial usage of cytosolic pyruvate is severely compromised.

  9. SIRT3 is decreased in the metastatic tissues and highly metastatic cell line of ovarian carcinoma. SIRT3 suppresses ovarian cancer cell migration and invasion in vitro.

  10. Interaction of SIRT3 with the palmitoyl group led to unfolding of the alpha3-helix. The myristoyl and palmitoyl groups bind to the C-pocket and an allosteric site near the alpha3-helix, respectively.

Mouse (Murine) Sirtuin 3 (SIRT3) Interaktionspartner

  1. expression and activity of the NADase CD38 increase with aging and that CD38 is required for the age-related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of SIRT3 activity.

  2. Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 enrichment within the mitochondria and subsequent upregulation of FoxO3a (zeige FOXO3 Proteine)-mediated mitochondria gene expression of PGC-1alpha and SOD2 (zeige SOD2 Proteine).

  3. These data demonstrate a critical role of SIRT3 in the control of myofibroblast differentiation and lung fibrosis.

  4. NMNAT3 (zeige NMNAT3 Proteine) regulates the activity of SIRT3 via synthesis of mitochondria NAD.

  5. Data show that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) overexpression significantly increased the expression of sirtuin 3 (SIRT3) and sirtuin 5 (SIRT5 (zeige SIRT5 Proteine)).

  6. These results suggest that the antiinflammatory phenotype of FABP4/aP2 null mice is mediated by increased intracellular monounsaturated fatty acids leading to the increased expression of both uncoupling protein 2 (zeige UCP2 Proteine) and SirT3.

  7. despite pre-existing defects in cardiac function and mitochondrial respiratory capacity in SIRT3(-/-) mice, SIRT3 deficiency does not additionally impair cardiac function following myocardial ischemia-reperfusion injury or following myocardial infarction

  8. In the cochlea, the expression of SIRT1 (zeige SIRT1 Proteine), 3, and 5 (both mRNA and protein) was decreased in the old mice

  9. SIRT3 plays pivotal roles in adaptive responses of neurons to physiological challenges and resistance to degeneration.

  10. Results point to an antioxidant defense mechanism presented by Sirt3 through the activation of Foxo3a (zeige FOXO3 Proteine), in microglia

Cow (Bovine) Sirtuin 3 (SIRT3) Interaktionspartner

  1. The results indicate that the variations in the class I sirtuin (zeige SIRT1 Proteine) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. The expression profile of sirtuin 1 (zeige SIRT1 Proteine) and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT3 Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Genbezeichner und Symbole assoziert mit Sirtuin 3 Proteine (SIRT3)

  • sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) (sirt3)
  • sirtuin 3 (SIRT3)
  • sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) (SIRT3)
  • sirtuin 3 (Sirt3)
  • 2310003L23Rik Protein
  • AI848213 Protein
  • Sir2l3 Protein
  • sirtuin Protein
  • zgc:158774 Protein

Bezeichner auf Proteinebene für Sirtuin 3 Proteine (SIRT3)

sirtuin 3 , sirtuin , NAD-dependent deacetylase sirtuin-3, mitochondrial , NAD-dependent protein deacetylase sirtuin-3, mitochondrial , SIR2-like protein 3 , mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase , regulatory protein SIR2 homolog 3 , silent mating type information regulation 2, S.cerevisiae, homolog 3 , sir2-like 3 , sirtuin type 3 , SIRT3 mitochondrial , NAD-dependent deacetylase sirtuin-3 , NAD-dependent protein deacetylase sirtuin-3 , SIRT3L mitochondrial , mSIR2L3 , mitochondrial protein lysine deacetylase , silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

GENE ID SPEZIES
558775 Danio rerio
100604320 Nomascus leucogenys
422988 Gallus gallus
23410 Homo sapiens
475933 Canis lupus familiaris
100354500 Oryctolagus cuniculus
64384 Mus musculus
293615 Rattus norvegicus
101087609 Felis catus
614027 Bos taurus
100125971 Sus scrofa
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