Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 Proteine (SERPINC1)

The protein encoded by SERPINC1 is a plasma protease inhibitor and a member of the serpin superfamily. Zusätzlich bieten wir Ihnen Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 Antikörper (287) und Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 Kits (62) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SERPINC1 462 P01008
SERPINC1 11905 P32261
SERPINC1 304917  
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Top Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 Proteine auf antikoerper-online.de

Showing 10 out of 34 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Human His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
Details
HOST_Human Cells Cynomolgus His tag 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
650,00 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_Human Human Unkonjugiert 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
157,14 €
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HOST_Escherichia coli (E. coli) Ratte His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
655,24 €
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HOST_Human Human Unkonjugiert   1 mg Anmelden zum Anzeigen 6 bis 8 Tage
222,25 €
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
457,14 €
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HOST_Human Human Unkonjugiert   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
284,17 €
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HOST_Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
609,52 €
Details

SERPINC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
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Mouse (Murine) , ,

Rat (Rattus) ,
,

Am meisten referenzierte Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 Proteine

  1. Human SERPINC1 Protein expressed in Human Cells - ABIN2002163 : Chuang, Swanson, Raja, Bock, Olson et al.: The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase ... in Biochemistry 2001 (PubMed)
    Zeige alle 5 Referenzen für 2002163

  2. Cynomolgus SERPINC1 Protein expressed in Human Cells - ABIN3216412 : Oelschläger, Römisch, Staubitz, Stauss, Leithäuser, Tillmanns, Hölschermann: Antithrombin III inhibits nuclear factor kappaB activation in human monocytes and vascular endothelial cells. in Blood 2002 (PubMed)
    Zeige alle 5 Referenzen für 3216412

  3. Human SERPINC1 Protein expressed in Human - ABIN491621 : Gardell, Krueger, Antrilli, Elokdah, Mayer, Orcutt, Crandall, Vlasuk: Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action. in Molecular pharmacology 2007 (PubMed)

Weitere Proteine zu Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 (SERPINC1) Interaktionspartnern

Human Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 (SERPINC1) Interaktionspartner

  1. The results this study reveal several novel mutations to the already growing list of SERPINC1 mutations, thereby adding to our knowledge of the molecular background of antithrombin deficiency.

  2. Data indicate that all patients suffered from homozygous antithrombin (AT) deficiency caused by the mutation p.Leu131Phe in the AT gene (SERPINC1).

  3. Studies indicate that antithrombin III (ATIII) and its gene SerpinC1 may be related to many diseases, including hypertension and kidney diseases.

  4. The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for SERPINC1 is 144.2 (95% CI, 26.3-779.4; P = 1.7 x 10- 7).

  5. In Hungary, the founder mutation, ATBp3, is the most common Antithrombin deficiency

  6. Our studies of ATIII in-cell folding reveal a surprising, biased order of disulfide bond formation, with early formation of the C-terminal disulfide, before formation of the N-terminal disulfides, critical for folding to the active, metastable state

  7. Describe antibody specifically targeting a unique conformational epitope on antithrombin III beta conformation that blocks anticoagulation.

  8. This is the first case of pregnancy related stroke, associated with type-II heparin binding site antithrombin deficiency (c. 391C > T, p.Leu131Phe), that has been reported so far. A genetic analysis of the AT gene (SERPINC1) was performed.

  9. Elevated levels of circulating microparticles can play a role in carriers of mild and severe inherited thrombophilia resulting from antithrombin deficiency.

  10. The relevance of the vitamin D pathway on the regulation of SERPINC1 was confirmed in a cell model.

Mouse (Murine) Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 (SERPINC1) Interaktionspartner

  1. RNA interference of Serpinc1 and/or Proc allows for evaluation of the function of these genes in vivo and provides a novel, controlled mouse model for spontaneous venous thrombosis.

Cow (Bovine) Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 (SERPINC1) Interaktionspartner

  1. ATIII may be protective in HIV-1 disease by inhibiting HIV-1 replication

Serine (Or Cysteine) Peptidase Inhibitor, Clade C (Antithrombin), Member 1 (SERPINC1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

Genbezeichner und Symbole assoziert mit SERPINC1

  • serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1)
  • antithrombin-III (CpipJ_CPIJ000472)
  • antithrombin-III (CpipJ_CPIJ013111)
  • serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 (Serpinc1)
  • serpin peptidase inhibitor, clade C (antithrombin), member 1 (Serpinc1)
  • AI114908 Protein
  • ANTITHROMBIN, AT-III Protein
  • At-3 Protein
  • AT-III Protein
  • At3 Protein
  • AT3D Protein
  • ATIII Protein
  • DKFZp470C1733 Protein
  • SERPINC1 Protein
  • THPH7 Protein

Bezeichner auf Proteinebene für SERPINC1

antithrombin-III , serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 , serpin peptidase inhibitor, clade C (antithrombin), member 1 , Antithrombin-III , anti-thrombin 3 , antithrombin , serpin C1 , serpin peptidase inhibitor, clade C, member 1 , ATIII , antithrombin III , serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1

GENE ID SPEZIES
462 Homo sapiens
6031327 Culex quinquefasciatus
6045984 Culex quinquefasciatus
100173818 Pongo abelii
100379601 Cavia porcellus
11905 Mus musculus
424440 Gallus gallus
480066 Canis lupus familiaris
540261 Bos taurus
100125972 Sus scrofa
304917 Rattus norvegicus
443407 Ovis aries
100061173 Equus caballus
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