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SOSTDC1 is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. Zusätzlich bieten wir Ihnen SOSTDC1 Antikörper (47) und SOSTDC1 Kits (24) und viele weitere Produktgruppen zu diesem Protein an.
Showing 8 out of 9 products:
Human SOSTDC1 Protein expressed in Wheat germ - ABIN1320977
Lee, Miyazawa, Shin, Kwon, Kang, Choi, Lee, Kondo, Cho, Jung: Shh signaling is essential for rugae morphogenesis in mice. in Histochemistry and cell biology 2011
Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 (zeige CCNA2 Proteine) and cyclin E2 (zeige CCNE2 Proteine).
Results conclude that the transcriptional repressor E4BP4 (zeige NFIL3 Proteine) plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 (zeige NFIL3 Proteine) silencing.
Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer
Unliganded VDR (zeige CYP27B1 Proteine) upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1.
DNA methylation (zeige HELLS Proteine) is involved in the down-regulation of SOSTDC1 expression in gastric cancer.
SOSTDC1 is expressed in normal breast tissue and this expression is reduced in breast cancer.
Results indicate for the first time that the genetic polymorphisms in SOSTDC1 have an effect on attainment and maintenance of peak bone mass in Chinese women.
genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors.
Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways
USAG1 is expressed in the kidney and functions as a bone morphogenetic protein antagonist.
suggest that RUNX2 (zeige RUNX2 Proteine) and USAG-1 act in an antagonistic manner
the in vivo inter-relationships between Bmp7 (zeige BMP7 Proteine) and Usag-1, was examined.
Findings strongly suggest that Wise and Sost (zeige SOST Proteine) are key modulators of bone development through the ability of their encoded proteins to interact with Lrp5 (zeige LRP5 Proteine) and control the balance or levels of Wnt (zeige WNT2 Proteine) signaling.
Interactions between BMP-7 (zeige BMP7 Proteine) and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations
Sost (zeige SOST Proteine) and its paralog Sostdc1 coordinate digit number in a Gli3 (zeige GLI3 Proteine)-dependent manner.
Wise controls the number and distribution of the mammary epithelial cells via inhibition of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.
Data suggest that Sostdc1 primarily regulates bone morphogenetic protein pathway in pancreatic islets; knockout/mutation of Sostdc1 enhances down-regulation of Ctgf (connective tissue growth factor (zeige CTGF Proteine)) and gremlin (zeige GREM1 Proteine) in islets after high-fat diet.
The data demonstrate that simvastatin contributes to prevent the progression of renal fibrosis by upregulating BMP-7 (zeige BMP7 Proteine)-mediated anti-fibrotic signaling and that one aspect of crucial efficacies is achieved by regulating HOXA13 (zeige HOXA13 Proteine) and USAG-1.
The data suggested that functions of Sostdc1 can be largely attributed to its ability to attenuate Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.
We propose a new reaction-diffusion model in which Wnt (zeige WNT2 Proteine), Shh (zeige SHH Proteine) and Sostdc1 act as the activator, mediator and inhibitor, respectively, and confirm that such interactions can generate the tooth pattern of a wild-type mouse.
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.
sclerostin domain containing 1
, sclerostin domain-containing protein 1
, Sclerostin domain-containing protein 1
, uterine sensitization-associated gene 1 protein
, wnt-signaling modulator
, cystine-knot containing secreted protein
, ectodermal BMP inhibitor
, uterine sensitization-associated protein-1
, sclerostin-like protein
, uterine sensitization-associated protein 1
, context-dependent activator and inhibitor of Wnt signalling protein Wise