Sclerostin Domain Containing 1 Proteine (SOSTDC1)

SOSTDC1 is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. Zusätzlich bieten wir Ihnen SOSTDC1 Antikörper (47) und SOSTDC1 Kits (24) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte SOSTDC1 SOSTDC1 266803 Q642G2
SOSTDC1 25928 Q6X4U4
SOSTDC1 66042 Q9CQN4
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Top SOSTDC1 Proteine auf antikoerper-online.de

Showing 8 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$333.33
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$319.00
Details
Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$694.00
Details
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,436.50
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$656.00
Details
Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$893.75
Details

SOSTDC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) ,
,

Am meisten referenzierte SOSTDC1 Proteine

  1. Human SOSTDC1 Protein expressed in Wheat germ - ABIN1320977 : Lee, Miyazawa, Shin, Kwon, Kang, Choi, Lee, Kondo, Cho, Jung: Shh signaling is essential for rugae morphogenesis in mice. in Histochemistry and cell biology 2011 (PubMed)

Weitere Proteine zu Sclerostin Domain Containing 1 (SOSTDC1) Interaktionspartnern

Human Sclerostin Domain Containing 1 (SOSTDC1) Interaktionspartner

  1. Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 (zeige CCNA2 Proteine) and cyclin E2 (zeige CCNE2 Proteine).

  2. Results conclude that the transcriptional repressor E4BP4 (zeige NFIL3 Proteine) plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 (zeige NFIL3 Proteine) silencing.

  3. Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer

  4. Unliganded VDR (zeige CYP27B1 Proteine) upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1.

  5. DNA methylation (zeige HELLS Proteine) is involved in the down-regulation of SOSTDC1 expression in gastric cancer.

  6. SOSTDC1 is expressed in normal breast tissue and this expression is reduced in breast cancer.

  7. Results indicate for the first time that the genetic polymorphisms in SOSTDC1 have an effect on attainment and maintenance of peak bone mass in Chinese women.

  8. genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors.

  9. Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways

  10. USAG1 is expressed in the kidney and functions as a bone morphogenetic protein antagonist.

Mouse (Murine) Sclerostin Domain Containing 1 (SOSTDC1) Interaktionspartner

  1. suggest that RUNX2 (zeige RUNX2 Proteine) and USAG-1 act in an antagonistic manner

  2. the in vivo inter-relationships between Bmp7 (zeige BMP7 Proteine) and Usag-1, was examined.

  3. Findings strongly suggest that Wise and Sost (zeige SOST Proteine) are key modulators of bone development through the ability of their encoded proteins to interact with Lrp5 (zeige LRP5 Proteine) and control the balance or levels of Wnt (zeige WNT2 Proteine) signaling.

  4. Interactions between BMP-7 (zeige BMP7 Proteine) and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations

  5. Sost (zeige SOST Proteine) and its paralog Sostdc1 coordinate digit number in a Gli3 (zeige GLI3 Proteine)-dependent manner.

  6. Wise controls the number and distribution of the mammary epithelial cells via inhibition of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.

  7. Data suggest that Sostdc1 primarily regulates bone morphogenetic protein pathway in pancreatic islets; knockout/mutation of Sostdc1 enhances down-regulation of Ctgf (connective tissue growth factor (zeige CTGF Proteine)) and gremlin (zeige GREM1 Proteine) in islets after high-fat diet.

  8. The data demonstrate that simvastatin contributes to prevent the progression of renal fibrosis by upregulating BMP-7 (zeige BMP7 Proteine)-mediated anti-fibrotic signaling and that one aspect of crucial efficacies is achieved by regulating HOXA13 (zeige HOXA13 Proteine) and USAG-1.

  9. The data suggested that functions of Sostdc1 can be largely attributed to its ability to attenuate Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.

  10. We propose a new reaction-diffusion model in which Wnt (zeige WNT2 Proteine), Shh (zeige SHH Proteine) and Sostdc1 act as the activator, mediator and inhibitor, respectively, and confirm that such interactions can generate the tooth pattern of a wild-type mouse.

SOSTDC1 Protein Überblick

Protein Überblick

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.

Genbezeichner und Symbole assoziert mit SOSTDC1

  • sclerostin domain containing 1 (SOSTDC1)
  • sclerostin domain containing 1a (sostdc1a)
  • sclerostin domain containing 1 (Sostdc1)
  • 0610006G05Rik Protein
  • DKFZp469J0531 Protein
  • ectodin Protein
  • SOSTDC1 Protein
  • Sostl Protein
  • USAG-1 Protein
  • USAG1 Protein
  • WISE Protein
  • zgc:110293 Protein

Bezeichner auf Proteinebene für SOSTDC1

sclerostin domain containing 1 , sclerostin domain-containing protein 1 , Sclerostin domain-containing protein 1 , USAG-1 , uterine sensitization-associated gene 1 protein , wnt-signaling modulator , cystine-knot containing secreted protein , ectodermal BMP inhibitor , uterine sensitization-associated protein-1 , sclerostin-like protein , uterine sensitization-associated protein 1 , context-dependent activator and inhibitor of Wnt signalling protein Wise

GENE ID SPEZIES
482331 Canis lupus familiaris
550261 Danio rerio
100173799 Pongo abelii
266803 Rattus norvegicus
25928 Homo sapiens
66042 Mus musculus
378800 Gallus gallus
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