anti-Runt-Related Transcription Factor 1 (RUNX1) Antikörper

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Zusätzlich bieten wir Ihnen RUNX1 Kits (14) und RUNX1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top anti-RUNX1 Antikörper auf antikoerper-online.de

Showing 10 out of 279 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: Jurkat cell lysate WB Suggested Anti-RUNX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500  Positive Control: Jurkat cell lysate  RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB Sample Type : Mouse, post-natal day (p) 0 retinal ganglion cells Primary Antibody Dilution : 1:1500 Secondary Antibody : Donkey anti rabbit IgG Alexa 594 Secondary Antibody Dilution : 1:1000 Gene Name : RUNX1  Submitted by : Anonymous WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: PANC1 cell lysate There is BioGPS gene expression data showing that RUNX1 is expressed in PANC1 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate WB Suggested Anti-RUNX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: Jurkat cell lysate  RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:7812500Positive Control: Human Small Intestine 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: SH-SYSY cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert FACS, IF, IHC (p), WB Western blot analysis of RUNX1-S276 (ABIN650732) in K562 cell line lysates (35 µg/lane). RUNX1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with RUNX1 Antibody (S276) (ABIN650732), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from HepG2 cells treated with PMA 125ng/ml 30', using AML1 (Phospho-Ser435) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from HepG2 cells, treated with PMA 125ng/ml 30', using AML1 (Ab-435) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Kaninchen Unkonjugiert WB AML-1/Runx1 antibody tested by Western blot. Detection of AML-1/Runx1 by Western blot analysis. Positive detection of AML-1/Runx1 in nuclear extracts derived from Jurkat cells at 1:500 (lane 1) and 1:1,000 (lane 2) dilutions. 100 μL Anmelden zum Anzeigen 1 bis 3 Tage
497,22 €
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RUNX1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-RUNX1 Antikörper

  1. Human Polyclonal RUNX1 Primary Antibody für WB - ABIN2668716 : Zaidi, Dowdy, van Wijnen, Lian, Raza, Stein, Croce, Stein: Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. in Cancer research 2009 (PubMed)
    Zeige alle 19 Referenzen für 2668716

  2. Human Polyclonal RUNX1 Primary Antibody für FACS, IF - ABIN650732 : Moosavi, Sanchez, Adeyinka: Marker chromosomes are a significant mechanism of high-level RUNX1 gene amplification in hematologic malignancies. in Cancer genetics and cytogenetics 2009 (PubMed)
    Zeige alle 2 Referenzen für 650732

  3. Human Polyclonal RUNX1 Primary Antibody für ELISA, WB - ABIN1532121 : Nucifora, Birn, Espinosa, Erickson, LeBeau, Roulston, McKeithan, Drabkin, Rowley: Involvement of the AML1 gene in the t(3,21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. in Blood 1993 (PubMed)

  4. Cow (Bovine) Polyclonal RUNX1 Primary Antibody für WB - ABIN2792628 : Takeshita, Ichikawa, Nitta, Goyama, Asai, Ogawa, Chiba, Kurokawa: AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. in Leukemia 2008 (PubMed)

  5. Cow (Bovine) Polyclonal RUNX1 Primary Antibody für WB - ABIN2780380 : Ghozi, Bernstein, Negreanu, Levanon, Groner: Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)

Weitere Antikörper gegen RUNX1 Interaktionspartner

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center

  2. hemogenic competency in recently specified endothelial progenitors is restrained through the active silencing of Runx1 expression.

  3. Leukaemogenesis by AML1-ETO (zeige RUNX1T1 Antikörper) requires enhanced C/D box snoRNA/RNP (zeige RNPC3 Antikörper) formation.

  4. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (zeige F2 Antikörper)-activatable receptor PAR-1 (protease-activated receptor-1 (zeige F2R Antikörper)), in Runx1/Cbfb (zeige CBFB Antikörper)-deleted MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) cells. Similar to the effect of Runx1/Cbfb (zeige CBFB Antikörper) deletion, PAR-1 (zeige MARK2 Antikörper) overexpression induced CDKN1A/p21 (zeige CDKN1A Antikörper) expression and attenuated proliferation in MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) cells

  5. Immunohistochemical staining for RUNX1 showed reactivity in angiogenic tufts in the retina of mice with oxygen-induced retinopathy, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.

  6. The Runx1-persistent group is involved in transmitting mechanical and thermal information, whereas the Runx1-transient group transmits pruriceptive information. Such hierarchical control mechanisms may provide a developmental solution for the formation of sensory circuits that transmit distinct modalities.

  7. RUNX1 was expressed in both mesenchymal and epithelial compartments of the developing and postnatal lung. Increased respiratory distress, inflammation, and proinflammatory cytokines were observed in the Runx1-deleted mice after pulmonary LPS (zeige TLR4 Antikörper) exposure. RUNX1 deletion was associated with the activation of NF-kappaB (zeige NFKB1 Antikörper) in respiratory epithelial cells. RUNX1 was required for the suppression of NF-kappaB (zeige NFKB1 Antikörper) signaling pathway.

  8. both repressor and activator functions of Runx1 at multiple hematopoietic stages and lineages likely contribute to the tumor suppressor activity in MDS (zeige MECOM Antikörper) and AML.

  9. Knock-down of PLC-gamma-1 (zeige PLCG1 Antikörper) induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 and subsequent PU.1 upregulation while subsequent rescue of RUNX1 in sh-PLC-gamma-1 (zeige PLCG1 Antikörper)-transfected cells strongly inhibited foreign body giant cell formation.

  10. this study shows that distinct, asynchronous and stage-specific transcription factors (TCF-1 (zeige HNF1A Antikörper), GATA-3 (zeige GATA3 Antikörper) and Runx1) activate Bcl11b (zeige BCL11B Antikörper) for T cell commitment

Human Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Our findings strengthen previous data concerning RUNX1 mutations in acute myeloid leukemia (zeige BCL11A Antikörper) and support the notion that RUNX1 mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (zeige BCL11A Antikörper).

  2. Heterozygous germ line mutations in the RUNX1 gene are responsible genetic events for FPD/AML.

  3. Data suggest that RUNX1 pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1, either mutations in RUNX1 gene or variations in expression of RUNX1, appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  4. The E3 ubiquitin ligase (zeige MUL1 Antikörper) STUB1 (zeige STUB1 Antikörper) is a negative regulator of both RUNX1 and RUNX1-RUNX1T1 (zeige RUNX1T1 Antikörper). Activation of STUB1 (zeige STUB1 Antikörper) could be a promising therapeutic strategy for RUNX1-RUNX1T1 (zeige RUNX1T1 Antikörper) leukemia.

  5. The clinical significance of ETV6 (zeige ETV6 Antikörper)-RUNX1.

  6. Deliver the necessary promotional drive for the progression of ETV6 (zeige ETV6 Antikörper)-RUNX1+ pre-leukaemic cells.

  7. High RUNX1 expression is associated with pancreatic cancer.

  8. these findings have identified a novel function for Runx1 in sustaining normal mammary epithelial morphology and preventing epithelial-mesenchymal transition

  9. Leukaemogenesis by AML1-ETO (zeige RUNX1T1 Antikörper) requires enhanced C/D box snoRNA/RNP (zeige RNPC3 Antikörper) formation.

  10. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (zeige F2 Antikörper)-activatable receptor PAR-1 (protease-activated receptor-1 (zeige F2R Antikörper)), in Runx1/Cbfb (zeige CBFB Antikörper)-deleted MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) cells. Similar to the effect of Runx1/Cbfb (zeige CBFB Antikörper) deletion, PAR-1 (zeige MARK2 Antikörper) overexpression induced CDKN1A/p21 (zeige CDKN1A Antikörper) expression and attenuated proliferation in MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) cells

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (zeige CTCF Antikörper) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (zeige MYEF2 Antikörper) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (zeige RAD21 Antikörper), or cohesin subunit Smc3 (zeige SMC3 Antikörper), fail to express runx3 (zeige RUNX3 Antikörper) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (zeige RUNX2 Antikörper) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Antigen-Profil

Protein Überblick

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit RUNX1

  • runt-related transcription factor 1 (RUNX1) Antikörper
  • runt-related transcription factor (runt) Antikörper
  • runt related transcription factor 1 (Runx1) Antikörper
  • runt-related transcription factor 1 (runx1) Antikörper
  • runt-related transcription factor 1 (Runx1) Antikörper
  • AI462102 Antikörper
  • aml Antikörper
  • aml-1 Antikörper
  • Aml1 Antikörper
  • aml1-evi-1 Antikörper
  • amlcr1 Antikörper
  • cbfa2 Antikörper
  • evi-1 Antikörper
  • Pebp2a2 Antikörper
  • pebp2ab Antikörper
  • Pebpa2b Antikörper
  • Runx-1 Antikörper
  • runx1 Antikörper
  • runxa Antikörper
  • XAML Antikörper
  • Xaml1 Antikörper

Bezeichner auf Proteinebene für RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPEZIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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