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Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Zusätzlich bieten wir Ihnen RUNX1 Kits (14) und RUNX1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 271 products:
Human Polyclonal RUNX1 Primary Antibody für EIA, WB - ABIN500646
Lee, Jenner, Boyer, Guenther, Levine, Kumar, Chevalier, Johnstone, Cole, Isono, Koseki, Fuchikami, Abe, Murray, Zucker, Yuan, Bell, Herbolsheimer, Hannett, Sun, Odom, Otte, Volkert, Bartel, Melton, Gifford, Jaenisch, Young: Control of developmental regulators by Polycomb in human embryonic stem cells. in Cell 2006
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Human Polyclonal RUNX1 Primary Antibody für FACS, IF - ABIN650732
Moosavi, Sanchez, Adeyinka: Marker chromosomes are a significant mechanism of high-level RUNX1 gene amplification in hematologic malignancies. in Cancer genetics and cytogenetics 2009
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Cow (Bovine) Polyclonal RUNX1 Primary Antibody für WB - ABIN2792567
Takeshita, Ichikawa, Nitta, Goyama, Asai, Ogawa, Chiba, Kurokawa: AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. in Leukemia 2008
Human Polyclonal RUNX1 Primary Antibody für ELISA, WB - ABIN1533152
Nucifora, Birn, Espinosa, Erickson, LeBeau, Roulston, McKeithan, Drabkin, Rowley: Involvement of the AML1 gene in the t(3,21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. in Blood 1993
Chicken Polyclonal RUNX1 Primary Antibody für WB - ABIN2780380
Ghozi, Bernstein, Negreanu, Levanon, Groner: Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. in Proceedings of the National Academy of Sciences of the United States of America 1996
Knock-down of PLC-gamma-1 (zeige PLCG1 Antikörper) induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 and subsequent PU.1 upregulation while subsequent rescue of RUNX1 in sh-PLC-gamma-1 (zeige PLCG1 Antikörper)-transfected cells strongly inhibited foreign body giant cell formation.
this study shows that distinct, asynchronous and stage-specific transcription factors (TCF-1 (zeige HNF1A Antikörper), GATA-3 (zeige GATA3 Antikörper) and Runx1) activate Bcl11b (zeige BCL11B Antikörper) for T cell commitment
Inhibition of Runx1 in multipotential myeloid precursor cells is important for osteoclast formation and function.
Silencing of Runx1 attenuated the LPS (zeige TLR4 Antikörper)-induced IL-1beta (zeige IL1B Antikörper) and IL-6 (zeige IL6 Antikörper) production levels, but the TNF-alpha (zeige TNF Antikörper) levels were not affected. Overexpression of RUNX1 promoted IL-1beta (zeige IL1B Antikörper) and IL-6 (zeige IL6 Antikörper) production in response to LPS (zeige TLR4 Antikörper) stimulation.
the Acute Myeloid Leukemia-1a (AML-1a) transcription factor, a regulator of immune gene expression, was identified as potentially sensitive to nucleosomal regulation within the Ly49 gene family. This result was confirmed in RMA, a cell line with natural expression of Ly49, using MNase-Seq to generate a nucleosome map of chromosome 6, where the Ly49 gene family is located
Data show that immature Runx1-deficient CD4 (zeige CD4 Antikörper)(+) T cells are eliminated in the periphery by the activation and fixation of the classical complement pathway.
Runx1 deficiency enhanced CGRP expression and disrupted BMP4-induced neurite outgrowth inhibition in DRG.
Runx1 could be manipulated after injury to promote neuronal differentiation to facilitate repair of the CNS.
Runx1 haploinsufficiency appears to predispose FPD patients to MM by expanding the pool of stem/progenitor cells and blocking myeloid differentiation in response to G-CSF (zeige CSF3 Antikörper).
Runx1 has an important role in Nf1 (zeige NF1 Antikörper) neurofibroma initiation
RUNX1 and AXIN1 (zeige AXIN1 Antikörper) proteins are strongly correlated in ER(-) tumors as well.
he data suggest a central role for RUNX1 as master regulator of gene expression in the U87 glioblastoma multiforme cell line and mark RUNX1 as a potential target for novel future therapies for glioblastoma multiforme
Study highlights the importance of interactions among lncRNA HCP5, microRNA-139, and transcription factor RUNX1 in regulating the malignant behavior of glioma cells. HCP5 down-regulated miR-139 to up-regulate RUNX1. RUNX1 promoted AEG-1 expression, which was involved in a series of oncogenic effects in glioma cells. RUNX1 also up-regulated HCP5 expression, which formed a positive feedback loop.
Data suggest that RUNX1 functions in stem cells regulating cell differentiation; cancer cells appear to have corrupted this function of RUNX1 into promotion of oncogenesis. [REVIEW]
the AML1-ETO (zeige RUNX1T1 Antikörper) fusion protein increases the expression of SIRT1 (zeige SIRT1 Antikörper), possibly by binding to the promoter region of SIRT1 (zeige SIRT1 Antikörper) to activate its transcription in t(8;21) AML.
the Notch (zeige NOTCH1 Antikörper) pathway DNA-binding protein (zeige UBE2V1 Antikörper) RBP-J (zeige RBPJ Antikörper) is the key cellular factor hijacked by EBNA2 to direct activation of RUNX1 transcription via upstream super-enhancers.
revealed more than 170 NFAT (zeige NFATC1 Antikörper)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (zeige NFATC1 Antikörper) and NFATc2 (zeige NFAT1 Antikörper) in T cells, such as Raptor (zeige RPTOR Antikörper), CHEK1 (zeige CHEK1 Antikörper), CREB1 (zeige CREB1 Antikörper), RUNX1, SATB1 (zeige SATB1 Antikörper), Ikaros (zeige IKZF1 Antikörper), and Helios (zeige ZNFN1A2 Antikörper).
Data show that the interaction between aptamer and AML1 (RUNX1) protein DNA-binding domain known as the Runt domain (RD) is driven by a large enthalpy change.
A feedback circuitry involving miR (zeige MLXIP Antikörper)-9-1 and RUNX1-RUNX1T1 (zeige RUNX1T1 Antikörper).
The requirement for Runx1 in the normal hematopoietic development and its dysregulation through chromosomal translocations and loss-of-function mutations as found in acute myeloid leukemias highlight the importance of this transcription factor in the healthy blood system.
Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development
We propose that cohesin and CTCF (zeige CTCF Antikörper) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.
Morpholino knockdown of Myef2 (zeige MYEF2 Antikörper) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.
Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.
hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta
in zebrafish adult HSCs can be formed without an intact runx1.
Zebrafish embryos lacking Rad21 (zeige RAD21 Antikörper), or cohesin subunit Smc3 (zeige SMC3 Antikörper), fail to express runx3 (zeige RUNX3 Antikörper) and lose hematopoietic runx1 expression in early embryonic development.
Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.
ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).
reveal a shift in Runx2 (zeige RUNX2 Antikörper) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.
runt-related transcription factor 1
, runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)
, runt-related transcription factor
, runt protein
, PEA2-alpha B
, PEBP2-alpha B
, SL3-3 enhancer factor 1 alpha B subunit
, SL3/AKV core-binding factor alpha B subunit
, acute myeloid leukemia 1 protein
, core binding factor alpha 2
, core-binding factor subunit alpha-2
, oncogene AML-1
, polyomavirus enhancer-binding protein 2 alpha B subunit
, runt domain, alpha subunit 2
, AML1-EVI-1 fusion protein
, core-binding factor, runt domain, alpha subunit 2
, runt-related transcription factor a
, Acute myeloid leukemia 1 protein
, Core-binding factor subunit alpha-2
, aml1 oncogene
, acute myeloid leukemia 1
, factor, runt domain, alpha subunit 2
, core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene)
, runt related transcription factor 1