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The protein encoded by RNASEH2A is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). Zusätzlich bieten wir Ihnen RNASEH2A Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal RNASEH2A Primary Antibody für ELISA, ICC - ABIN4350704
Tresini, Warmerdam, Kolovos, Snijder, Vrouwe, Demmers, van IJcken, Grosveld, Medema, Hoeijmakers, Mullenders, Vermeulen, Marteijn: The core spliceosome as target and effector of non-canonical ATM signalling. in Nature 2015
the G37S mutation of RNaseH2 led to increased expression of interferon (zeige IFNA Antikörper)-stimulated genes dependent on the cGAS-STING signaling pathway.
Recent evidence gathered from ribonuclease H2 knock-out mice provides insight into the molecular mechanisms underlying Aicardi-Goutieres syndrome development and a potential role of DNA damage as a trigger of autoimmunity is discussed. [review]
analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome
Data show that the interwoven architecture of RNase H2B (zeige RNASEH2B Antikörper) and RNase H2C (zeige RNASEH2C Antikörper) that interface with RNase H2A in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-protein interaction motifs.
RNaseH2A may be involved in human gliomagenesis.
This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2A in patients with Aicardi-Goutieres Syndrome.
RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B (zeige RNASEH2B Antikörper)-dependent manner.
Studies indicate that most antiviral-defense systems involve RNase H-like enzymes destroying invading nucleic acids, RNA, or DNA.
study identified two synonymous variants in RNASEH2A that result in loss of RNase H2 enzyme function and the consequent Aicardi-Goutieres syndrome phenotype
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.
ribonuclease H2, large subunit
, ribonuclease HI, large subunit
, RNase H2 subunit A
, RNase HI large subunit
, ribonuclease H2 subunit A
, ribonuclease HI large subunit
, ribonuclease HI subunit A
, RNase H(35)
, aicardi-Goutieres syndrome 4 protein