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Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Zusätzlich bieten wir Ihnen RALBP1 Antikörper (115) und RALBP1 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.
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Affects dynamics of the actin cytoskeleton, signalling from Ral (zeige rala Proteine) to RLIP is required for gastrulation.
These results demonstrate that to participate in the control of the actin cytoskeleton, RLIP needs its complete N-terminal region coding for the mu2BD and the GAP domain.
RLIP76 acts as a scaffold at recycling endosomes by binding activated R-Ras, recruiting ARNO (zeige CYTH2 Proteine) to activate Arf6 (zeige ARF6 Proteine), thereby contributing to cell spreading and migration.
a fundamental role of RLIP76 in regulating the function of obesity-promoting pro-inflammatory cytokines
RalBP1 is a gene regulating the seizure threshold and synaptic inhibition in mice
results establish that RLIP76 is required for efficient endothelial cell function and angiogenesis in solid tumors
RLIP76 represents a mechanistically significant target for developing effective interventions in aggressive and refractory pancreatic cancers
Studies confirmed a model in which RLIP76 plays a central role in the pathogenesis of metabolic syndrome and RLIP76 loss causes profound and global alterations of MSy signaling functions.
Findings show a fundamental role of RLIP76 in chemical carcinogenesis.
Because RLIP76 is induced by oxidative stress, it could play a role in insulin (zeige INS Proteine) resistance seen in pathological conditions characterized by increased oxidative stress
Data show that RLIP76 knockout mice are extremely sensitive to irradiation.
role in regulating endocytosis of activin type II receptors by ARIP2 (zeige SYNJ2BP Proteine)
the miR143-3p level was markedly lower in participants with ovarian cancer compared with normal control, while the expression of RALBP1 mRNA and protein were evidently overexpressed in participants with ovarian cancer compared with normal control.
RLIP76 knockdown increased autophagic flux and apoptosis in U251 glioma cells.
Phosphorylation level of Akt (zeige AKT1 Proteine) declined from 138.45+/-13.8 to 69.9+/-29.7% in SGC (zeige SGCB Proteine)-7901, and from 115.5+/-26.6 to 49.07+/-27% in MGC-803 and phosphorylation level of mTOR (zeige FRAP1 Proteine) also significantly decreased.While apoptosis of gastric cancer(GA) cells increased which we verified with apoptosis proteins and staining analysis. Our data showed that RLIP76 plays a significant oncogenic role in GC and it maybe a potential target in GC
Anti-tumor effect was exerted when miR (zeige MLXIP Proteine)-124 directly targeted RLIP76, a stress-inducible transporter that plays a crucial role in the development of melanoma.
report showed that RLIP76 expression was significantly increased in breast cancer samples and positively correlated with the malignant status of breast cancer patients; results indicated that high RLIP76 expression was associated with poor prognosis of breast cancer patients
RLIP76 expression is induced by TNF-alpha (zeige TNF Proteine) and follows the induction kinetics of inflammation markers, suggesting that inflammation can influence RLIP76 expression at the blood brain barrier.
RLIP76 downregulation in HT29 CRC (zeige CALR Proteine) cells suppressed cell growth, enhanced cell apoptosis, induced cell cycle arrest, and inhibited cell invasion by decreasing MMP2 (zeige MMP2 Proteine) expression.
High RLIP76 expression is associated with a poor outcome of meningioma.
results revealed that the effect of miR (zeige MLXIP Proteine)-101 on prostate cancer cell apoptosis was due to RLIP76 regulation of the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)/Bcl-2 (zeige BCL2 Proteine) signaling pathway
RalBP1 protein is an independent predictor of poor survival and early relapse for CRC (zeige CALR Proteine) patients
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin (By similarity).
ralA binding protein 1
, Ral interacting protein
, ralA-binding protein 1
, ralA-binding protein 1-like
, DNP-SG ATPase
, Ral-interacting protein 1
, dinitrophenyl S-glutathione ATPase
, ral-interacting protein 1
, 76 kDa Ral-interacting protein