Pyruvate Dehydrogenase Complex, Component X (PDHX) ELISA Kits

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. Zusätzlich bieten wir Ihnen Pyruvate Dehydrogenase Complex, Component X Antikörper (57) und Pyruvate Dehydrogenase Complex, Component X Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human PDHX PDHX 8050 O00330
PDHX 27402 Q8BKZ9
Anti-Ratte PDHX PDHX 311254  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Maus 5.8 pg/mL 23.5-1500 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$910.56
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Weitere ELISA Kits für Pyruvate Dehydrogenase Complex, Component X Interaktionspartner

Human Pyruvate Dehydrogenase Complex, Component X (PDHX) Interaktionspartner

  1. We propose testing for the R446* mutation in PDHX as a rapid first screening in Roma infants with metabolic acidosis.

  2. MiR (zeige MLXIP ELISA Kits)-26a regulates glucose metabolism of colorectal cancer cells by direct targeting PDHX.

  3. New mutation in PDHX gene found in two unrelated patients with Pyruvate dehydrogenase (zeige PDP ELISA Kits) deficiency.

  4. genetic association with systemic lupus erythematosus to a haplotype between PDHX and CD44 (zeige CD44 ELISA Kits) was established.

  5. determination that PDH (zeige PDP ELISA Kits) and complex III exist at a steady-state ratio of 1:100, 1:128 and 1:202 in HeLa cell extracts, fibroblast mitochondria and heart tissue mitochondria, respectively

  6. model of the pyruvate dehydrogenase (zeige PDP ELISA Kits) complex formed by E2 and E2 plus the E3-binding protein and binding of the E1 and E3 components

  7. specificity of pairing for human E3BP with E3 from its subcomplex structure to be most likely due to conformational rigidity of the binding fragment of the E3-binding domain of E3BP and its exquisite amino acid match with the E3 target interface

  8. A cluster of disease-causing E3 mutations located near the center of the E3BD/E3 interface prevents the efficient recruitment of these E3 variants by E3BP into the PDC (zeige PNKD ELISA Kits), leading to the dysfunction of the PDC (zeige PNKD ELISA Kits) catalytic machine.

  9. These data provide an additional case of E3BP deficiency with a unique and previously unreported deletion in the PDHX gene.

  10. Despite the presence of antibodies reactive with PDC (zeige PNKD ELISA Kits)-E3BP in the majority of primary biliary cirrhosis (PBC (zeige DLAT ELISA Kits)) patients this self-protein is not a dominant T-cell autoantigen in PBC (zeige DLAT ELISA Kits).

Mouse (Murine) Pyruvate Dehydrogenase Complex, Component X (PDHX) Interaktionspartner

  1. T1a/podoplanin (zeige PDPN ELISA Kits) is first expressed in prox 1 (zeige PROX1 ELISA Kits)-positive lymphatic progenitor cells, with predominant localization in the luminal plasma membrane of lymphatic endothelial cells during later development.

  2. In islet cells both fat and glucose regulate PDK (zeige PDK2 ELISA Kits) gene and protein expression and indicate that hyperglycemia and hyperlipidemia contribute to the decline in diabetic islet PDH (zeige PDP ELISA Kits) activity by increasing mRNA and protein expression of PDK (zeige PDK2 ELISA Kits).

Cow (Bovine) Pyruvate Dehydrogenase Complex, Component X (PDHX) Interaktionspartner

  1. This study showed that the recombinant and bovine E2/E3BP cores bind E3s with a 2:1 stoichiometry, and propose that mammalian PDC (zeige PDC ELISA Kits) comprises a heterogeneous population of assemblies incorporating a network of E3 cross-bridges above the core surface.

Pyruvate Dehydrogenase Complex, Component X (PDHX) Antigen-Profil

Beschreibung des Gens

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit\; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Genbezeichner und Symbole assoziert mit PDHX

  • pyruvate dehydrogenase complex, component X (pdhx) Antikörper
  • pyruvate dehydrogenase complex component X (PDHX) Antikörper
  • pyruvate dehydrogenase complex component X L homeolog (pdhx.L) Antikörper
  • E3-binding protein (pdhX) Antikörper
  • pyruvate dehydrogenase complex component X (pdhx) Antikörper
  • pyruvate dehydrogenase complex, component X (Pdhx) Antikörper
  • Ac1164 Antikörper
  • AI481367 Antikörper
  • DDBDRAFT_0168431 Antikörper
  • DDBDRAFT_0230192 Antikörper
  • DDB_0168431 Antikörper
  • DDB_0230192 Antikörper
  • DLDBP Antikörper
  • E3bp Antikörper
  • MGC86218 Antikörper
  • OPDX Antikörper
  • PDHX Antikörper
  • Pdx1 Antikörper
  • proX Antikörper
  • zgc:66110 Antikörper
  • zgc:85977 Antikörper

Bezeichner auf Proteinebene für PDHX

pyruvate dehydrogenase complex, component X , pyruvate dehydrogenase protein X component, mitochondrial-like , dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex , lipoyl-containing pyruvate dehydrogenase complex component X , pyruvate dehydrogenase complex, E3-binding protein subunit , pyruvate dehydrogenase complex, lipoyl-containing component X , pyruvate dehydrogenase protein X component, mitochondrial , dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex (E3-binding protein) (proX) , E3-binding protein , E3BP , proX , pyruvate dehydrogenase protein X component

GENE ID SPEZIES
393532 Danio rerio
423154 Gallus gallus
447247 Xenopus laevis
451120 Pan troglodytes
8618072 Dictyostelium discoideum AX4
100059260 Equus caballus
100220979 Taeniopygia guttata
100349815 Oryctolagus cuniculus
100379696 Xenopus (Silurana) tropicalis
100455315 Pongo abelii
100475970 Ailuropoda melanoleuca
100544023 Meleagris gallopavo
100586539 Nomascus leucogenys
8050 Homo sapiens
27402 Mus musculus
311254 Rattus norvegicus
475942 Canis lupus familiaris
517402 Bos taurus
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