Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 Proteine (KCNJ6)

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Zusätzlich bieten wir Ihnen Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 Antikörper (69) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
KCNJ6 3763 P48051
KCNJ6 16522 P48542
KCNJ6 25743 P48550
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Showing 7 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,041.49
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$205.80
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$312.71
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KCNJ6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

Weitere Proteine zu Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6) Interaktionspartnern

Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6) Interaktionspartner

  1. The KCNJ6 -1250A and COMT (zeige COMT Proteine) Val alleles are predisposing preterm newborns to diminished opioid-induced pain relief.

  2. The major findings of the current study are 1) an additive genotypic effect of the KCNJ6 SNP on the ERO theta power phenotype during reward processing, increasing significantly across genotypes.

  3. Three of the four KCNJ6 SNPs studied here were found to be significantly associated with the same theta event related oscillations in adults.

  4. The findings of this study suggest that variations in KCNJ6 genes are associated with both mild and severe persistent breast pain after breast cancer surgery.

  5. KCNJ6 (GIRK2) gene polymorphism rs2835859 could serve as a marker that predicts sensitivity to analgesics and pain and susceptibility to nicotine dependence.

  6. In this transgenic mouse model, GIRK2 plays a major role in the genesis of infantile spasms.

  7. Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel (zeige KCNJ1 Proteine) encoded by KCNJ6.

  8. For KCNJ6, three SNPs (i.e., rs2835914, rs8129919, rs2836050) were associated with the occurrence of preoperative breast pain.

  9. Ethanol associates directly with the GIRK channel, leading to enhanced interaction with a membrane phospholipid phosphatidylinositol 4,5-bisphosphate and activation of the channel.

  10. 3.5 A resolution crystal structure of the mammalian GIRK2 channel in complex with betagamma G-protein subunits, the central signalling complex that links G-protein-coupled receptor (zeige ADRA1A Proteine) stimulation to K(+) channel (zeige KCNC4 Proteine) activity

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6) Interaktionspartner

  1. The GABABR-coupled GIRK2 channel is necessary for the GABABR agonist-induced infantile spasms phenotype in the Ts mouse and may represent a novel therapeutic target for the treatment of infantile spasms in Down syndrome.

  2. It was concluded that GIRK2, through its dual responsiveness to G protein beta (zeige GNB3 Proteine)-gamma and Na+, mediates a form of neuronal inhibition that is amplifiable in the setting of excess electrical activity.

  3. cholesterol did not affect the unitary conductance of GIRK2, it significantly enhanced the frequency of channel openings.

  4. Results indicate that GIRK channels formed by GIRK2 subunits determine depression-related behaviors as well as basal and 5-HT1A receptor (zeige CC2D1A Proteine)-mediated dorsal raphe neuronal activity

  5. This study showed that spontaneous GIRK2 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.

  6. This study demonstrated that the residue Ser-196 in Kir3.2 is involved in conferring PKC-mediated inhibition to the channel.

  7. In the ventral tegmental area, GABA neurons express both GIRK2 (and GIRK1 (zeige KCNJ3 Proteine)) subunits.

  8. Gbeta (zeige SUCLG2 Proteine)-gamma and PIP2 must be present simultaneously to activate GIRK2.

  9. Ligand-operated activation of Kir3.2 appears to cause dilation of the pore at the cytoplasmic domain, and is regulated conformationally.

  10. A subcellular GIRK2c/GIRK3 (zeige KCNJ9 Proteine) pathway is identified that regulates excitability of ventral tegmental area dopamine neurons.

Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6) Protein Überblick

Protein Überblick

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.

Genbezeichner und Symbole assoziert mit KCNJ6

  • potassium voltage-gated channel subfamily J member 6 (KCNJ6)
  • potassium channel, inwardly rectifying subfamily J, member 5 (kcnj5)
  • potassium inwardly-rectifying channel, subfamily J, member 6 (KCNJ6)
  • potassium inwardly-rectifying channel, subfamily J, member 6 (Kcnj6)
  • potassium voltage-gated channel subfamily J member 6 (Kcnj6)
  • BIR1 Protein
  • GIRK-2 Protein
  • GIRK2 Protein
  • hiGIRK2 Protein
  • KATP-2 Protein
  • KATP2 Protein
  • kcnj6 Protein
  • KCNJ7 Protein
  • Kir3.2 Protein
  • weaver Protein
  • wv Protein

Bezeichner auf Proteinebene für KCNJ6

potassium inwardly-rectifying channel, subfamily J, member 6 , G-protein-coupled inward rectifier potassium channel , G protein-activated inward rectifier potassium channel 2 , inward rectifier K(+) channel Kir3.2 , inward rectifier potassium channel KIR3.2 , GIRK-2 , potassium channel, inwardly rectifying subfamily J member 6 , potassium inwardly-rectifying channel J6 , BIR1 , GIRK2 , KATP-2 , Inward rectifier K(+) channel Kir3.2 , Potassium channel, inwardly rectifying subfamily J member 6 , potassium channel-like protein

GENE ID SPEZIES
427983 Gallus gallus
520743 Bos taurus
549655 Xenopus (Silurana) tropicalis
100625084 Sus scrofa
3763 Homo sapiens
16522 Mus musculus
25743 Rattus norvegicus
101823647 Mesocricetus auratus
100174134 Pongo abelii
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