Poly-U Binding Splicing Factor 60KDa Proteine (PUF60)

PUF60 encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. Zusätzlich bieten wir Ihnen PUF60 Antikörper (130) und PUF60 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PUF60 67959 Q3UEB3
PUF60 84401  
PUF60 22827 Q9UHX1
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Top PUF60 Proteine auf antikoerper-online.de

Showing 6 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,617.17
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$771.00
Details

PUF60 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Rat (Rattus)

Human , ,
, ,

Am meisten referenzierte PUF60 Proteine

  1. Human PUF60 Protein expressed in HEK-293 Cells - ABIN2730160 : Fiorentino, Presby, Baer, Petri, Rieger, Soloski, Rosen, Mammen, Christopher-Stine, Casciola-Rosen: PUF60: a prominent new target of the autoimmune response in dermatomyositis and Sjögren's syndrome. in Annals of the rheumatic diseases 2016 (PubMed)

Weitere Proteine zu Poly-U Binding Splicing Factor 60KDa (PUF60) Interaktionspartnern

Human Poly-U Binding Splicing Factor 60KDa (PUF60) Interaktionspartner

  1. These results confirm that PUF60 is a major driver for the developmental, craniofacial, skeletal and cardiac phenotypes associated with the 8q24.3 microdeletion

  2. Heterozygote loss-of-function variants in PUF60 cause a phenotype comprising growth/developmental delay and craniofacial, cardiac, renal, ocular and spinal anomalies.

  3. Mutations in PUF60 gene is associated with idiopathic hypereosinophilic syndrome.

  4. Concomitant over expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer cells.

  5. Overexpression of far upstream element (FUSE) binding protein (FBP)-interacting repressor (FIR) supports growth of hepatocellular carcinoma.

  6. High FBP-interacting repressor expression is associated with hepatocellular carcinoma.

  7. The interaction between SAP155 and FIR/FIRDeltaexon2 not only integrates cell-cycle progression and c-Myc transcription by modifying P27 and P89 expression.

  8. Haploinsufficiency of each of SCRIB or PUF60 contribute uniquely to specific endophenotypes (e.g., coloboma, heart defects), and binary interaction potentially exacerbates other aspects of the clinical pathology of individuals with 8q24.3 deletion.

  9. Circulating FIR (zeige FARP2 Proteine) variant mRNA in the peripheral blood of cancer patients were significantly overexpressed compared to that in healthy volunteers.

  10. Data indicate that altered FIR (zeige FARP2 Proteine) and c-myc (zeige MYC Proteine) pre-mRNA splicing, in addition to c-Myc (zeige MYC Proteine) expression by augmented FIR (zeige FARP2 Proteine)/FIRDeltaexon2-SAP155 (zeige SF3B1 Proteine) complex, potentially contribute to colorectal cancer development.

PUF60 Protein Überblick

Protein Überblick

This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit PUF60

  • poly-U binding splicing factor 60 (Puf60)
  • poly(U) binding splicing factor 60 (PUF60)
  • 2410104I19Rik Protein
  • 2810454F19Rik Protein
  • FIR Protein
  • RoBPI Protein
  • Siahbp1 Protein

Bezeichner auf Proteinebene für PUF60

60 kDa poly(U)-binding-splicing factor , fuse-binding protein-interacting repressor , poly(U)-binding-splicing factor PUF60 , FBP interacting repressor , RNA-binding protein Siah-BP , Ro ribonucleoprotein-binding protein 1 , poly-U binding splicing factor 60K , pyrimidine tract binding splicing factor , siah binding protein 1; FBP interacting repressor; pyrimidine tract binding splicing factor; Ro ribonucleoprotein-binding protein 1 , siah-binding protein 1 , FUSE-binding protein-interacting repressor , Siah binding protein 1

GENE ID SPEZIES
67959 Mus musculus
84401 Rattus norvegicus
22827 Homo sapiens
607245 Canis lupus familiaris
512824 Bos taurus
100174042 Pongo abelii
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