Piezo-Type Mechanosensitive Ion Channel Component 1 Proteine (PIEZO1)

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. Zusätzlich bieten wir Ihnen PIEZO1 Antikörper (42) und PIEZO1 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PIEZO1 9780 Q92508
PIEZO1 234839  
Ratte PIEZO1 PIEZO1 361430 Q0KL00
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 5 bis 7 Tage
324,01 €
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PIEZO1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human

Mouse (Murine)

Weitere Proteine zu Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Interaktionspartnern

Human Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Interaktionspartner

  1. differential regulation of PKA and cell stiffness in unconfined versus confined cells is abrogated by dual, but not individual, inhibition of Piezo1 and myosin II.

  2. data demonstrate that PIEZO1 is required for the regulation of NO formation, vascular tone, and blood pressure.

  3. The Piezo1 convert a variety of mechanical stimuli into channel activation and subsequent inactivation, and what molecules and mechanisms modulate Piezo function.

  4. Because Piezo1 senses both mechanical crowding and stretch, it may act as a homeostatic sensor to control epithelial cell numbers, triggering extrusion and apoptosis in crowded regions and cell division in sparse regions.

  5. platelets and Meg (zeige PTPN4 Proteine)-01 cells express the MS cation channel (zeige TRPV1 Proteine) Piezo1, which may contribute to Ca(2 (zeige CA2 Proteine)+) entry and thrombus formation under arterial shear.

  6. correlation between HPCHA and PIEZO1-gene mutated findings raise an important question as to whether any of the high phosphatidylcholine (zeige SGMS2 Proteine) hemolytic anemia cases previously diagnosed in Japan may have in fact been the form of hemolytic anemia known as hereditary xerocytosis or dehydrated hereditary stomatocytosis with PIEZO1 gene mutation

  7. Piezo1 responds to lateral membrane tension with exquisite sensitivity as compared to other mechanically activated channels and that resting tension can drive channel inactivation, thereby tuning overall mechanical sensitivity of Piezo1.

  8. Mutations in PIEZO1 is associated with persistent lymphoedema caused by congenital lymphatic dysplasia.

  9. Homozygous and compound heterozygous mutations in PIEZO1, result in an autosomal recessive form of generalized lymphatic dysplasia with a high incidence of non-immune hydrops fetalis and childhood onset of facial and four limb lymphoedema.

  10. Mechanically activated Piezo1 plays an essential role in red blood cell volume homeostasis.

Mouse (Murine) Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Interaktionspartner

  1. data demonstrate that PIEZO1 is required for the regulation of NO formation, vascular tone, and blood pressure.

  2. Our results suggest that Piezo1 is unlikely to be a component of the mechanoelectrical transducer channel complex in mammalian cochlear outer hair cells

  3. Smooth muscle Piezo1 is required for stretch-activated cationic channel activity. PIezo1 is involved in the remodeling of small arteries.

  4. This study demonstrated that Piezo1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.

  5. Astrocytes in optic nerve head express multiple mechanosensitive channels, in particular Piezo1 and 2. The expression of putative mechanosensitive channels in these cells may contribute to their responsiveness to traumatic or glaucomatous injury.

  6. cryo-electron microscopy structure of the full-length (2,547 amino acids) mouse Piezo1 (Piezo1) at a resolution of 4.8 A

  7. Piezo1 channels as sensors of blood flow was shown by Piezo1 dependence of shear-stress-evoked ionic current and calcium influx in endothelial cells and the ability of exogenous Piezo1 to confer sensitivity to shear stress on otherwise resistant cells

  8. Piezo1 is activated by shear stress, the major type of mechanical force experienced by endothelial cells in response to blood flow.

  9. overexpression of Piezo1 or Piezo2 induced 2 kinetically distinct mechanically activated (MA) currents; Piezos are expressed in several tissues; propose that Piezos are components of MA cation channels

PIEZO1 Protein Überblick

Protein Überblick

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010

Genbezeichner und Symbole assoziert mit PIEZO1

  • piezo-type mechanosensitive ion channel component 1 (PIEZO1)
  • piezo-type mechanosensitive ion channel component 1 (Piezo1)
  • 9630020g22 Protein
  • DHS Protein
  • Fam38a Protein
  • Mib Protein
  • mKIAA0233 Protein

Bezeichner auf Proteinebene für PIEZO1

family with sequence similarity 38, member A , membrane protein induced by beta-amyloid treatment , protein PIEZO1

GENE ID SPEZIES
9780 Homo sapiens
234839 Mus musculus
361430 Rattus norvegicus
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