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The protein encoded by PLTP is one of at least two lipid transfer proteins found in human plasma. Zusätzlich bieten wir Ihnen PLTP Antikörper (86) und PLTP Kits (38) und viele weitere Produktgruppen zu diesem Protein an.
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identification and characterization of CaM-binding domain of non-specific lipid transfer proteins
PLTP activity did not affect this metric. Thus, deviations in PLTP activity from the wild-type level reduce HDL (zeige HSD11B1 Proteine) mass and ex vivo cholesterol efflux capacity, but not the rate of macrophage cholesterol efflux to plasma or in vivo mRCT.
serum CETP (zeige CETP Proteine) and PLTP activity in patients diagnosed with hypothyroidism, was examined.
PLTP may regulate cigarette smoke extract-induced IL-8 expression via the ERK1/2 signaling pathway in human pulmonary epithelial cells
LPL (zeige LCP1 Proteine) and PLTP appear to be novel glioma-associated proteins and play a role in the progression of human glioma
association of PON-1 (zeige PON1 Proteine) activity with PLTP activity was lost in analysis which included large HDL (zeige HSD11B1 Proteine) particles
a novel association between PLTPa and PON1 (zeige PON1 Proteine) activity
The domain of apolipoprotein E4 required for PLTP activation resides within its amino-terminal 1-185 region.
Elevated baseline plasma levels of PLTP are associated with an increased risk of long-term all-cause mortality in patients with diabetes and known or suspected coronary disease.
This review summarizes the recent progresses made in the PLTP research field and focuses on the complexity of the implication of PLTP in obesity, insulin (zeige INS Proteine) resistance and type 2 diabetes mellitus. [review]
Elevated plasma PLTP activity may predict an increased risk of T2DM in men
this work reports a physiological role for PLTP in the polarization of CD4 (zeige CD4 Proteine)(+) T cells toward the pro-inflammatory Th1 (zeige HAND1 Proteine) phenotype.
these findings elucidated that PLTP repressed LPS (zeige TLR4 Proteine) induced inflammation due to extracellular LPS (zeige TLR4 Proteine) binding capability, and the protective effects were not related to HDL (zeige HSD11B1 Proteine) pool size in mice.
Data presented a novel model to link phospholipid metabolism to APP (zeige APP Proteine) processing and also suggested that PLTP played an important role in Abeta (zeige APP Proteine) metabolism and would be useful to further elucidate functions of PLTP in Alzheimer's disease susceptibility.
In hepatocytes, initial recruitment of phospholipid (PL) by apoB (zeige APOB Proteine):1000 leading to the formation of the PL-rich apoB (zeige APOB Proteine)-containing initiation complex is mediated to a large extent by PLTP.
PLTP plays an important role in modulating the stability of atherosclerotic plaques. The receptor-interacting protein 3 (zeige RIPK3 Proteine)- reactive oxygen species signal pathway could be involved in this PLTP-mediated process.
Adipocyte PLTP plays a small but significant role in plasma PLTP activity and promotes cholesterol efflux from adipose tissues.
PLTP exerts significant effects on apoA-I (zeige APOA1 Proteine) lipidation and nascent HDL (zeige HSD11B1 Proteine) biogenesis in hepatocytes by promoting ATP-binding cassette transporter A1 (zeige ABCA1 Proteine)-mediated lipid efflux and the remodeling of nascent HDL (zeige HSD11B1 Proteine) particles.
Plasma Sphingosine-1-phosphate contents were decreased by 60.1 % in PLTP knockout mice (PLTP-/-, N = 5) compared with their wild type littermates (WT, N = 5) (151.70 +/- 38.59 vs. 379.32 +/- 59.90 nmol/l, P<0.01).
Therefore we concluded that PLTP deficiency impaired cognition and aggravated AD by enhancing the generation of Abeta (zeige APP Proteine) in the cortex of old mice.
Cerebrovascular oxidative stress increased in PLTP deficient mice, including increased levels of reactive oxygen species (ROS) and lipid peroxidation marker 4-hydroxy-2-nonenal (HNE) and reduced superoxide dismutase (SOD) activity.
PLTP is actively involved in lipid transfer, cholesterol efflux, HDL (zeige HSD11B1 Proteine) genesis, and remodeling at the blood-brain barrier.
Results suggest that phospholipid transfer protein (PLTP) polymorphisms might be an important genetic influence on economic traits in Hanwoo (Korean cattle).
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.
phospholipid transfer protein
, BPI fold containing family E
, lipid transfer protein II
, plasma phospholipid transfer protein
, PLTP-like protein