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6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Zusätzlich bieten wir Ihnen PGD Proteine (24) und PGD Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PGD Primary Antibody für ICC, IF - ABIN441587
Elf, Lin, Xia, Pan, Shan, Wu, Lonial, Gaddh, Arellano, Khoury, Khuri, Lee, Boggon, Fan, Chen: Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. in Oncogene 2016
Show all 2 Pubmed References
These results indicate that the PHGDH (zeige PHGDH Antikörper) gene expression, dictated by IL-2R signaling, is a crucial event for DNA synthesis during S phase of activated T cells.
Using transgenic mice expressing enhanced GFP under the Srr (zeige SRR Antikörper) promoter and mice with targeted deletion of Srr (zeige SRR Antikörper) or 3-Phosphoglycerate dehydrogenase (zeige PHGDH Antikörper), we demonstrate predominantly neuronal sources of d-serine dependent on astrocytic supply of l-serine.
Elevated levels of 4E-BP1 (zeige EIF4EBP1 Antikörper) may be involved in a mechanism to arrest brain development in Phgdh (zeige PHGDH Antikörper) knock out embryos.
Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence
Phgdh (zeige PHGDH Antikörper) deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of brain D-serine, an N-methyl-D-aspartate receptor (zeige GRIN1 Antikörper) co-agonist
Data suggest expression of Phgdh (zeige PHGDH Antikörper) in endometrium is regulated by Hoxa10 (zeige HOXA10 Antikörper).
Taken together, these data suggest that ADD1/SREBP1c (zeige SREBF1 Antikörper) is a key transcription factor for 6PGDH gene expression and would coordinate glucose metabolism and lipogenesis for energy homeostasis.
the Phgdh (zeige PHGDH Antikörper)-dependent phosphorylated pathway is essential for normal embryonic development, especially for brain morphogenesis
the presence of cis (zeige CISH Antikörper)-acting elements confer the cell type specificity of Phgdh (zeige PHGDH Antikörper) transcription in the distal promoter region.
The mouse Phgdh (zeige PHGDH Antikörper) gene spans approximately 27 kilobases in length and comprises 12 exons with 11 intervening introns and is mapped to chromosome 3, region F2-F3 by FISH.
Studies indicate link between the 6-phosphogluconate dehydrogenase, oxidative pentose phosphate pathway (PPP) and lipogenesis through Ru-5-P-dependent inhibition of serine/threonine protein kinase LKB1 (zeige STK11 Antikörper)-AMPK (zeige PRKAA1 Antikörper) signalling.
copy number gain of the PGD gene was consistently identified in cervical cancers but not in the normal tissues
Results show that 6PGD activity is upregulated with increased lysine acetylation in primary leukemia cells from human patients, providing mechanistic insights into 6PGD upregulation in cancer cells.
Expression of 6PGD positively correlates with advancing stage of lung carcinoma. Knockdown of 6PGD by shRNA potently inhibits c-Met tyrosine phosphorylation.
Data suggest that the affinity of Nox2 (zeige CYBB Antikörper) for NADPH (zeige NQO1 Antikörper) is increased in the presence of 6PGDH on cell stimulation.
Hsa (zeige CD24 Antikörper)-miR (zeige MLXIP Antikörper)-132 and -212 were negatively correlated with PGD in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders.
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.
, 6-phosphogluconate dehydrogenase
, NADP-6 phosphogluconate dehydrogenase
, phosphogluconate dehydrogenase
, 6-phosphogluconate dehydrogenase, decarboxylating
, 3-phosphoglycerate dehyrogenase
, D-3-phosphoglycerate dehydrogenase
, 6-phosphogluconate dehydrogenase (decarboxylating)