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PYCARD encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). Zusätzlich bieten wir Ihnen PYCARD Antikörper (150) und PYCARD Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Data show that NOD-like receptor signaling genes NOD2 (zeige NOD2 ELISA Kits), PYCARD, CARD6 (zeige CARD6 ELISA Kits), and IFI16 (zeige IFI16 ELISA Kits) are upregulated in psoriatic epidermis.
The methylated status of ASC/TMS1 promoter had the potential applicability for clinical evaluation the prognosis of gastric cancer
it appears that ASC transcript expression may be a surrogate marker for depression and may represent a link between depression and the altered immune responses observed in these categories of individuals with elevated depressive symptoms.
The proteins of NLRP3 (zeige NLRP3 ELISA Kits), ASC, and caspase-1 (zeige CASP1 ELISA Kits) were observed in infiltrating inflammatory cells in cholesteatoma and chronic otitis media.
ASC/TMS1 methylation was significantly correlated with higher tumor nuclear grade. ASC/TMS1 is a novel functional tumor suppressor in renal carcinogenesis.
ASC Induces Procaspase-8 Death Effector Domain Filaments
ASC interacts with NALP3 (zeige NLRP3 ELISA Kits) and caspase-1 (zeige CASP1 ELISA Kits) via different domains.
The proteins (HSP90b (zeige HSP90AB1 ELISA Kits), TSM1 and L-plastin (zeige LCP1 ELISA Kits)) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases.
caspase-1 (zeige CASP1 ELISA Kits)/ASC inflammasomes play a significant role in the activation of IL-1beta (zeige IL1B ELISA Kits)/ROS (zeige ROS1 ELISA Kits) and NF-kappaB (zeige NFKB1 ELISA Kits) signaling of cytokine gene expression for T. cruzi control in human and mouse macrophages.
Neutralization of ASC improves sperm motility in men with spinal cord injuries.
Data show that T cell-intrinsic PYD and CARD domain containing protein ASC is required for TH17-mediated experimental autoimmune encephalomyelitis (EAE).
Data suggest that interleukin 22 (IL-22 (zeige IL22 ELISA Kits)) plays a pro-inflammatory/pathogenic role in the onset of antigen-induced arthritis (AIA) through apoptosis-associated speck-like Pycard protein (ASC (zeige STS ELISA Kits))-dependent stimulation of interleukin-1 beta (IL-1beta (zeige IL1B ELISA Kits)) production.
report herein that lack of ASC (zeige STS ELISA Kits) does not confer preferential protection in response to P. aeruginosa acute infection and that ASC (zeige STS ELISA Kits)(-/-) mice are capable of producing robust amounts of IL-1beta (zeige IL1B ELISA Kits) comparable with C57BL/6 mice
These data identify a novel non-canonical immunoregulatory function of NLRP3 (zeige NLRP3 ELISA Kits) and ASC (zeige STS ELISA Kits) in autoimmunity.
a significant role for NLRP3 (zeige NLRP3 ELISA Kits) and ASC (zeige STS ELISA Kits) in prion (zeige PRNP ELISA Kits) pathogenesis
ASC (zeige STS ELISA Kits)-driven caspase-1 (zeige CASP1 ELISA Kits) autoprocessing and speck formation are dispensable for the activation of caspase-1 (zeige CASP1 ELISA Kits) and the NLRP1b inflammasome.
IKKalpha (zeige CHUK ELISA Kits) controls the inflammasome at the level of the adaptor molecule ASC (zeige STS ELISA Kits), which interacts with IKKalpha (zeige CHUK ELISA Kits) in the nucleus of resting macrophages in an IKKalpha (zeige CHUK ELISA Kits) kinase-dependent manner.
Hypoxia-induced elevated right ventricular pressure and remodeling were attenuated in mice lacking the inflammasome adaptor protein ASC (zeige STS ELISA Kits), suggesting that inflammasomes play an important role in the pathogenesis of pulmonary hypertension.
gene deficiency results in absence of IL-1beta (zeige IL1B ELISA Kits) maturation in the middle ear response to non-typeable Haemophilus influenza, and in reduction of both leukocyte infiltration and macrophage phagocytosis
Data (including data from studies using knockout mice) suggest that Asc is required for macrophage activation and inflammasome-dependent secretion of interleukin 1beta from peritoneal macrophages upon exposure to silica particles.
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
apoptosis-associated speck-like protein containing a CARD
, caspase recruitment domain-containing protein 5
, target of methylation-induced silencing 1
, PYD and CARD domain-containing protein