anti-PDZ Binding Kinase (PBK) Antikörper

PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Zusätzlich bieten wir Ihnen PDZ Binding Kinase Proteine (14) und PDZ Binding Kinase Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PBK 55872 Q96KB5
PBK 52033 Q9JJ78
PBK 290326  
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Top anti-PDZ Binding Kinase Antikörper auf antikoerper-online.de

Showing 10 out of 142 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-PBK Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>721_B cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Maus Unkonjugiert IF, WB Western blot analysis of PBK on a Jurkat cell lysate (Human T-cell leukemia, ATCC TIB-152). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the anti-PBK antibody. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$154.07
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti- PBK Picoband antibody, IHC(P) IHC(P): Mouse Testis Tissue Anti- PBK Picoband antibody, Western blotting All lanes: Anti PBK  at 0.5ug/ml Lane 1: Rat Testis Tissue Lysate at 50ug Lane 2: Mouse Testis Tissue Lysate at 50ug Lane 3: Human Placenta Tissue Lysate at 50ug Lane 4: JURKAT Whole Cell Lysate at 40ug Predicted bind size: 36KD Observed bind size: 36KD 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from COS7 cells, treated with Nocodazole 1ug/ml 16h, using PBK/TOPK (Ab-9) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PBK/TOPK (Ab-9) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from K562 cells treated with UV 30', using PBK/TOPK (Phospho-Thr9) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Maus Unkonjugiert ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of Hela cells using PBK mouse mAb (green) and negative control (red) . 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$430.10
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$357.50
Details
Human Kaninchen Unkonjugiert WB Mouse Pbk Antibody (N-term) (ABIN1881635) western blot analysis in MDA-MB453 cell line lysates (35 µg/lane). This demonstrates the Mouse Pbk antibody detected the Mouse Pbk protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$200.00
Details

PBK Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-PDZ Binding Kinase Antikörper

  1. Human Monoclonal PBK Primary Antibody für IF, WB - ABIN968771 : Abe, Matsumoto, Kito, Ueda: Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. in The Journal of biological chemistry 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal PBK Primary Antibody für IF, WB - ABIN968772 : Gaudet, Branton, Lue: Characterization of PDZ-binding kinase, a mitotic kinase. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal PBK Primary Antibody für ICC, FACS - ABIN969345 : Oh, Zhu, Cho, Lee, Kang, Kim, Zykova, Bode, Dong: T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. in Cancer research 2007 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal PBK Primary Antibody für WB - ABIN1881635 : Zykova, Zhu, Lu, Higgins, Tatsumi, Abe, Bode, Dong: Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal PBK Primary Antibody für ICC, IF - ABIN4343992 : Mulder, Björling, Jonasson, Wernérus, Hober, Hökfelt, Uhlén: Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. in Molecular & cellular proteomics : MCP 2009 (PubMed)

Weitere Antikörper gegen PDZ Binding Kinase Interaktionspartner

Human PDZ Binding Kinase (PBK) Interaktionspartner

  1. MiR (zeige MLXIP Antikörper)-770-5p and PBK levels were inversely correlated in xenograft model mice.

  2. TOPK knockdown did not alter radiation response in normal tissues, but significantly enhanced radiosensitivity in cancer cells.These findings have clinical relevance, as elevated TOPK protein expression was associated with poorer clinical outcomes in prostate cancer patients treated with radical radiotherapy. TOPK disruption may cause tumour-specific radiosensitisation in multiple different tumour types.

  3. Determined the crystal structure of PBK, which has two phospho-mimicking mutations T9E and T198E. The structural data indicated that PBK may assemble into an inactive dimer in alkaline conditions. Analytical size-exclusion chromatography and analytical ultracentrifugation confirmed that PBK exists in a conformational transition between dimers and monomers at different pH conditions.

  4. PBK/TOPK plays a crucial role in tumour malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer.

  5. A high PBK expression level was correlated with long overall survival in oral squamous cell carcinoma.

  6. findings suggest that PBK/TOPK plays a crucial role in tumor malignant potential through its overexpression in ESCC

  7. TOPK silencing sensitizes EGFR (zeige EGFR Antikörper)-TKI-resistant lung cancer cells to gefitinib and increases gefitinib efficacy in preclinical lung adenocarcinoma xenograft models.

  8. Study shows that BUB1beta (zeige BUB1B Antikörper) and PDZ binding kinase are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.

  9. Overexpression of Nrf2 (zeige GABPA Antikörper) inhibited the PBK/TOPK KD-induced decrease in cdc2 (zeige CDK1 Antikörper) and cyclin B expression and cell cycle arrest, and blocked ROS (zeige ROS1 Antikörper) production and apoptosis.

  10. The in vitro data have been consistent with a role for PBK/TOPK in facilitating invasion in prostate cancer. PBK could be a prognostic biomarker for prostate cancer that would discriminate aggressive prostate cancer from indolent disease.

Mouse (Murine) PDZ Binding Kinase (PBK) Interaktionspartner

  1. this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN (zeige PTEN Antikörper)/Akt (zeige AKT1 Antikörper) signaling pathway

  2. T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (zeige DUSP1 Antikörper) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (zeige RNF19A Antikörper) signaling pathway.

  3. The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.

  4. Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.

PDZ Binding Kinase (PBK) Antigen-Profil

Protein Überblick

This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.

Genbezeichner und Symbole assoziert mit PBK

  • PDZ binding kinase (PBK) Antikörper
  • PDZ binding kinase (pbk) Antikörper
  • PDZ binding kinase (Pbk) Antikörper
  • PDZ binding kinase L homeolog (pbk.L) Antikörper
  • 2810434B10Rik Antikörper
  • AW538537 Antikörper
  • CT84 Antikörper
  • D14Ertd732e Antikörper
  • Nori-3 Antikörper
  • PBK Antikörper
  • SPK Antikörper
  • TOPK Antikörper
  • zgc:92050 Antikörper

Bezeichner auf Proteinebene für PBK

PDZ binding kinase , T-LAK cell-originated protein kinase , MAPKK-like protein kinase , cancer/testis antigen 84 , lymphokine-activated killer T-cell-originated protein kinase , serine/threonine protein kinase , spermatogenesis-related protein kinase , PDZ-binding kinase , PBK, PDZ-binding kinase , lymphokine-activated killer T-cell-originated protein kinase homolog

GENE ID SPEZIES
422003 Gallus gallus
464496 Pan troglodytes
496810 Xenopus (Silurana) tropicalis
713242 Macaca mulatta
100341076 Oryctolagus cuniculus
100587879 Nomascus leucogenys
55872 Homo sapiens
52033 Mus musculus
360218 Danio rerio
496340 Xenopus laevis
477371 Canis lupus familiaris
100141310 Sus scrofa
534781 Bos taurus
290326 Rattus norvegicus
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