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The protein encoded by PAK7 is a member of the PAK family of Ser/Thr protein kinases. Zusätzlich bieten wir Ihnen PAK7 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PAK7 Primary Antibody für ICC, ELISA - ABIN1002958
Jaffer, Chernoff: p21-activated kinases: three more join the Pak. in The international journal of biochemistry & cell biology 2002
Show all 3 Pubmed References
Data suggest expression of ECAD (E-cadherin (zeige CDH1 Antikörper)) in bladder cancer cell lines correlates with presence of intercellular junctions and level of PAK5 (zeige PAK6 Antikörper) (p21 (zeige CDKN1A Antikörper)-activated kinase PAK5 (zeige PAK6 Antikörper) protein) expression; endogenous PAK5 (zeige PAK6 Antikörper) is localized to intercellular junctions and interacts with ECAD (zeige CDH1 Antikörper); depletion of PAK5 (zeige PAK6 Antikörper) expression reduces integrity of intercellular junctions; PAK5 (zeige PAK6 Antikörper) mRNA levels are reduced in bladder cancer compared with normal controls.
model suggests PAK5 self-association interferes with AID binding to the catalytic domain, thus maintaining its high activity.
PAK7 expression is significantly downregulated in human masticatory mucosa during wound healing
PAK7 is overexpressed in human esophageal squamous cell cancer samples and correlated with lymph node metastasis.
E47 (zeige TCF3 Antikörper) is a novel substrate of PAK5 (zeige PAK6 Antikörper), and PAK5 (zeige PAK6 Antikörper)-mediated phosphorylation of E47 (zeige TCF3 Antikörper) promotes epithelial-mesenchymal transition and metastasis of colon cancer.
Aurora-A induced PAK7 expression in esophageal cancer cells.
results suggest that the inhibition of PAK5 by RNA interference might efficiently suppress tumor development of glioma cells with PAK5 high expression.
miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma.
PAK7 promotes cell proliferation and tumorigenesis
It inhibits glioma cell migration and invasion potentially through the PAK5 (zeige PAK6 Antikörper)-Egr1 (zeige EGR1 Antikörper)-MMP2 (zeige MMP2 Antikörper) signaling pathway.
Xenopus PAK5 regulates convergent extension movements in vivo by modulating the calcium-mediated cell-cell adhesion in blastomeres.
PAK-7 p21-activated kinase 5 knockout mice are more sensitive to the stimulant effects of amphetamine
functional deficits in PAK5, PAK6 (zeige PAK6 Antikörper) and PAK5/PAK6 (zeige PAK6 Antikörper) knockout mice
PAK 5 is involved in formalin-induced inflammatory nociception through regulation of MAPK-induced c-Fos-activation and formalin-specific transient receptor potential-channels.
These results implicate Pak5 in Pacsin1 (zeige PACSIN1 Antikörper)- and Synaptojanin1-mediated synaptic vesicle trafficking.
PAK5 may provide a molecular rationale for late-stage complications in diabetes.
Our results indicate that Pak5 and Pak6 (zeige PAK6 Antikörper) together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory.
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.
, p21(CDKN1A)-activated kinase 7
, p21-activated kinase 5
, p21-activated kinase 7
, p21CDKN1A-activated kinase 7
, protein kinase PAK5
, serine/threonine-protein kinase PAK 7
, serine/threonine-protein kinase PAK7
, p21 (CDKN1A)-activated kinase 7