PAK7 Antikörper (AA 128-157)

Produktnummer ABIN3028909

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PAK7 in WB, IHC und ELISA. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für PAK7 Antikörper (AA 128-157) (ABIN3028909)

Target: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAK7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-PAK7 Antikörper

Bindungsspezifität: AA 128-157

Verwendungszweck: Pak7 Antibody / Pak5

Kreuzreaktivität (Details): Expected species reactivity: Rat

Aufreinigung: Antigen affinity

Immunogen: A portion of amino acids 128-157 from the mouse protein was used as the immunogen for this Pak7 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Pak7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Pak7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu PAK7

Target: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Andere Bezeichnung: Pak7

Hintergrund: Pak7, also called Pak5, is a serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity). [UniProt]

UniProt: Q8C015