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Expression of interleukin-3 (IL3\; MIM 147740) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Zusätzlich bieten wir Ihnen NFIL3 Kits (28) und NFIL3 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal NFIL3 Primary Antibody für ELISA, WB - ABIN257663
Zhang, Zhang, Kornuc, Kwan, Frank, Nimer: Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter. in Molecular and cellular biology 1995
Here we review the regulatory mechanisms of E4BP4 engaging in not only the biological function but also the development of immune-mediated diseases, paving the way for future therapies
glucocorticoid-mediated transactivating pathway may support eosinophil viability in IL-5 (zeige IL5 Antikörper)-stimulated cells through synergistic upregulation of NFIL3
E4BP4 and BIM (zeige BCL2L11 Antikörper) regulation correlated with that of RCAN1 (zeige RCAN1 Antikörper)-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1 (zeige RCAN1 Antikörper)-1
Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 (zeige SOSTDC1 Antikörper) expression in breast cancer cells, which can be reverted by E4BP4 silencing.
NFIL3 plays a neuroprotective role in neurons and constitutes a potential therapeutic target for neurodegeneration.
Data indicate that E4BP4 can inhibit CD40L (zeige CD40LG Antikörper) expression through epigenetic modifications in the promoter region of CD40L (zeige CD40LG Antikörper).
NFIL3 alters cancer cell behavior and FOXO (zeige FOXO3 Antikörper) function by acting on chromatin to restrict the menu of FOXO (zeige FOXO3 Antikörper) target genes
The clock-regulated and immune system modulator transcription factor E4BP4/ NFIL3 likely regulates the expression of both appb in zebrafish and APP (zeige APP Antikörper) in humans.
G9a (zeige EHMT2 Antikörper) mediates E4BP4-dependent suppression of hepatic Fgf21 (zeige FGF21 Antikörper) by enhancing histone methylation (H3K9me2) of the Fgf21 (zeige FGF21 Antikörper) promoter
Conclude that E4BP4 plays as a survival factor in heart and E4BP4 is essential for proper embryonic heart development.
Study shows that Nfil3 is enriched in the myeloid compartment of adult zebrafish including eosinophils.
conclude that E4BP4/NIFL3 plays as a survival factor in heart and E4BP4 is essential for proper embryonic heart development.
NFIL3 functions as an important regulator of glucose homeostasis in the liver by limiting CREB (zeige CREB1 Antikörper)-mediated hepatic gluconeogenesis.
We identified PD-1 (zeige PDCD1 Antikörper) to be specifically expressed in PLZF (zeige ZBTB16 Antikörper)(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3, ID2, and TCF-1 (zeige HNF1A Antikörper) was critical. Importantly, induction of ILC (zeige CCL27 Antikörper) lineage commitment required only transient expression of NFIL3 prior to ID2 and TCF-1 (zeige HNF1A Antikörper) expression.
Uterine lumen closure, early embryonic development, and differentiation of antimesometrial decidua were delayed in Nfil3(-/-) implantation sites. Major disturbances to the decidual-trophoblast interface that did not lead to fetal death were attributed to NFIL3 deficiency in trophoblast.
In hepatocytes, E4BP4 interacts with nuclear SREBP-1c (zeige SREBF1 Antikörper) to preserve its acetylation, and subsequently protects it from ubiquitination-dependent degradation
study found that approximately one quarter of the submandibular salivary gland (SMG (zeige SNRPG Antikörper)) NK cells develop independently of NFIL3; data show that the SMG (zeige SNRPG Antikörper) tissue environment shapes a unique repertoire of NK-like cells with distinct phenotypes
New direct Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) target gene Nfil3 , which induced epithelial-mesenchymal transition, cell migration and experimental metastasis of Colorectal cancer cells was identified.
removal of NFIL3 in vivo does not recapitulate the regeneration-promoting effects that were previously observed in vitro.
These findings establish that NFIL3 directs the differentiation of a committed innate lymphoid cell precursor.
These data identify an IL-27 (zeige IL27 Antikörper)/NFIL3 signalling axis as a key regulator of effector T-cell responses via induction of Tim-3 (zeige HAVCR2 Antikörper), IL-10 (zeige IL10 Antikörper) and T-cell dysfunction.
establish NFIL3 as a key regulator of common helper-like innate lymphoid cells progenitors as they emerge during early lymphopoiesis
Expression of interleukin-3 (IL3\; MIM 147740) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site (Zhang et al., 1995
nuclear factor, interleukin 3 regulated
, nuclear factor interleukin-3-regulated protein-like
, E4 promoter-binding protein 4
, interleukin-3 promoter transcriptional activator
, interleukin-3-binding protein 1
, nuclear factor interleukin 3 regulated protein
, nuclear factor interleukin-3-regulated protein
, transcriptional activator NF-IL3A
, E4 promoter binding-protein 4
, E4 binding protein 4-1
, bZIP protein E4BP4
, cE4BP4 protein
, embryo implantation-related NFIL3/E4BP4-like transcription factor