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The protein encoded by NBR1 was originally identified as an ovarian tumor antigen monitored in ovarian cancer. Zusätzlich bieten wir Ihnen Neighbor of BRCA1 Gene 1 Kits (6) und Neighbor of BRCA1 Gene 1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal NBR1 Primary Antibody für ELISA, WB - ABIN517601
Mardakheh, Yekezare, Machesky, Heath: Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling. in The Journal of cell biology 2009
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Human Polyclonal NBR1 Primary Antibody für ICC, IF - ABIN4337974
Cullup, Kho, Dionisi-Vici, Brandmeier, Smith, Urry, Simpson, Yau, Bertini, McClelland, Al-Owain, Koelker, Koerner, Hoffmann, Wijburg, ten Hoedt, Rogers, Manchester, Miyata, Hayashi, Said, Soler et al.: Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy. ... in Nature genetics 2012
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Human Polyclonal NBR1 Primary Antibody für ELISA, WB - ABIN517598
Mostowy, Sancho-Shimizu, Hamon, Simeone, Brosch, Johansen, Cossart: p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. in The Journal of biological chemistry 2011
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Human Polyclonal NBR1 Primary Antibody für WB - ABIN517599
Kuo, Chen, Baron, Onder, Loewer, Almeida, Weismann, Xu, Houghton, Gao, Daley, Doxsey: Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. in Nature cell biology 2011
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NBR1 is not required for PARK2 (zeige PARK2 Antikörper)-dependent mitophagy.
The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs (zeige FAS Antikörper), whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration.
NBR1 positively correlates with adipose inflammation in human obese patients. (zeige MAP3K3 Antikörper)
Analysis of muscle biopsies (zeige GSK3b Antikörper)of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation.
The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding.
structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin (zeige UBB Antikörper)
results suggest that NBR1 is the specific autophagy receptor for pexophagy.
These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy.
The structural ensemble representing each of the two sequential folding transition transition states of the PB1 (zeige SMR3A Antikörper) domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations.
Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases.
NBR1 is increased in adipose tissue macrophages in obese mice. The NBR1-MEKK3 (zeige MAP3K3 Antikörper) complex is important in JNK (zeige MAPK8 Antikörper) activation in macrophages.
NBR1 phosphorylation by GSK3 (zeige GSK3b Antikörper) at Thr586 prevents the aggregation of ubiquitinated proteins and their selective autophagic degradation.
In a mouse model of Huntington disease (zeige HTT Antikörper), NBR1 protein levels were decreased in all brain regions analyzed early in the disease, whereas at late stages they accumulated in the striatum and hippocampus, but not in the cortex.
MURF2 (zeige TRIM55 Antikörper) expression parallels that of the autophagy-associated proteins LC3 (zeige MAP1LC3A Antikörper), p62/SQSTM1 (zeige SQSTM1 Antikörper) and nbr1
Results define Nbr1 as a negative regulator of ligand-mediated receptor tyrosine kinase (zeige ERBB3 Antikörper) degradation and reveal the interplay between its various regions for protein localization and function.
NBR1 is a novel PB1 (zeige GPR97 Antikörper) adapter in Th2 differentiation and asthma.
might contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to mesothelin (zeige MSLN Antikörper)
The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B (zeige UBB Antikörper) chains. Nbr1 also binds to the autophagic effector protein LC3 (zeige MAP1LC3A Antikörper)-A via a novel binding site.
findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 (zeige SPRED2 Antikörper) via NBR1.
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.
neighbor of BRCA1 gene 1
, next to BRCA1 gene 1 protein
, next to BRCA1 gene 1 protein-like
, cell migration-inducing gene 19 protein
, membrane component chromosome 17 surface marker 2
, membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125)
, migration-inducing protein 19
, neighbor of BRCA1 gene 1 protein
, protein 1A1-3B
, membrane component chromosome 17 surface marker 2 homolog
, next to the Brca1
, ovarian carcinoma antigen CA125