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MEF2D is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Zusätzlich bieten wir Ihnen MEF2D Proteine (6) und MEF2D Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal MEF2D Primary Antibody für IHC - ABIN966557
Breitbart, Liang, Smoot, Laheru, Mahdavi, Nadal-Ginard: A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. in Development (Cambridge, England) 1994
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Human Polyclonal MEF2D Primary Antibody für IHC - ABIN966558
Zhao, New, Kravchenko, Kato, Gram, di Padova, Olson, Ulevitch, Han: Regulation of the MEF2 family of transcription factors by p38. in Molecular and cellular biology 1999
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Dog (Canine) Monoclonal MEF2D Primary Antibody für IF, IP - ABIN968169
Guttridge, Mayo, Madrid, Wang, Baldwin: NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. in Science (New York, N.Y.) 2000
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Dog (Canine) Monoclonal MEF2D Primary Antibody für IF, IP - ABIN968170
Martin, Miano, Hustad, Copeland, Jenkins, Olson: A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. in Molecular and cellular biology 1994
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MEF2D might be a potential biomarker during chronic inflammation-lung cancer transition, predicting the risk of lung cancer among patients with chronic respiratory diseases.
HIF-1alpha (zeige HIF1A Antikörper) transactivates MEF2D expression by binding to the MEF2D gene promoter to induce angiogenesis in colorectal tumors.
MEF2D directly regulated transcription of the epithelial-mesenchymal transition driver gene ZEB1 (zeige ZEB1 Antikörper) and facilitated histone acetylation at the ZEB1 (zeige ZEB1 Antikörper) promoter in colorectal cancer cells
MEF2D-BCL9 (zeige BCL9 Antikörper)-positive patients had B-cell precursor immunophenotype and were characterized as being older in age, being resistant to chemotherapy, having very early relapse, and having leukemic blasts that mimic morphologically mature B-cell leukemia with markedly high expression of HDAC9 (zeige HDAC9 Antikörper).
These results suggest that PPARgamma (zeige PPARG Antikörper) may exert its antiproliferative effects by negatively regulating the MEF2D in CM cells, which through upregulation of miR (zeige MLXIP Antikörper)-122, and PPARgamma (zeige PPARG Antikörper)/miR (zeige MLXIP Antikörper)-122/MEF2D signaling pathway may be a novel target for treatment of CM.
MEF2D overexpression participated in the growth of lung cancers and its aberrant expression may result from the reduction of tumor suppressor miR (zeige MLXIP Antikörper)-218.
MEF2D is a direct target of miR (zeige MLXIP Antikörper)-19.
We found that in malignant glioma, there is an aberrantly high expression of MEF2D, which leads to poor prognosis of malignant glioma. The downregulation of MEF2D suppresses the proliferation of malignant glioma cell lines by inducing delay of S and G2/M phases of cell cycle and promoting apoptosis.
MEF2D regulates IGF-1 (zeige IGF1 Antikörper)-induced proliferation and apoptosis in CM development, indicating IGF-1 (zeige IGF1 Antikörper)-MEF2D pathway may be a useful target for treatment.
Pokemon (zeige ZBTB7A Antikörper) was found to enhance the migration and invasion of hepatocellular carcinoma by increasing MEF2D expression
These findings uncover a novel role for Mef2c (zeige MEF2C Antikörper)/d in coordinating the transcriptional network that promotes early B-cell development.
This study identifies MEF2D as a critical regulator of IL-10 (zeige IL10 Antikörper) gene expression that negatively controls microglia inflammation response and prevents inflammation-mediated cytotoxicity.
Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells
miR (zeige MLXIP Antikörper)-103 worked through activating AKT (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) signal pathway and impairing target gene MEF2D.
These findings demonstrate that broadly expressed TFs acquire specific functions through competitive recruitment to enhancers by tissue-specific Mef2d and through selective activation of these enhancers to regulate tissue-specific genes.
Whereas MEF2A (zeige MEF2A Antikörper) is absolutely required for proper myoblast differentiation, MEF2B (zeige MEF2B Antikörper), -C, and -D were found to be dispensable for this process.
A role for endogenous MEF2 (zeige MEF2C Antikörper) factors exclusively in hormone/Fsk/cAMP-induced Nr4a1 (zeige NR4A1 Antikörper) gene expression in mouse MA-10 Leydig cells.
Oxidation of survival factor MEF2D inhibits its function, underlies oxidative stress-induced (zeige SQSTM1 Antikörper) neurotoxicity, and may be a part of the Parkinson disease pathogenic process.
Results demonstrate that coordinated alternative splicing by a single RNA binding protein modulates transcription (Mef2d) and cell signaling (Rock2 (zeige ROCK2 Antikörper)) programs to drive tissue-specific functions (cell fusion) to promote a developmental transition.
We found that Parkinson's disease -associated neurotoxins destabilize MEF2D mRNA and reduce its level in vitro and in vivo.
Expression analysis showed that the MEF2D polymorphisms were highly correlated with MEF2D mRNA and protein levels in the longissimus dorsi muscle of Polish Holstein-Friesian bulls carrying the three different combined genotypes.
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants.
myocyte enhancer factor 2D
, MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)
, myocyte-specific enhancer factor 2D-like
, MADS box transcription enhancer factor 2, polypeptide D
, myocyte-specific enhancer factor 2D