MEF2D Antikörper (AA 346-511)

Produktnummer ABIN968169

Produktdetails anti-MEF2D Antikörper

Target: MEF2D (Myocyte Enhancer Factor 2D (MEF2D))

Bindungsspezifität: AA 346-511

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MEF2D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Human, Ratte (Rattus), Hund

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse MEF2D aa. 346-511

Klon: 9-MEF2D

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968535, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-MEF2D Antikörper (ABIN968169)

Guttridge, Mayo, Madrid, Wang, Baldwin: "NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia." in: Science (New York, N.Y.), Vol. 289, Issue 5488, pp. 2363-6, (2000) (PubMed).

Mora, Pessin: "The MEF2A isoform is required for striated muscle-specific expression of the insulin-responsive GLUT4 glucose transporter." in: The Journal of biological chemistry, Vol. 275, Issue 21, pp. 16323-8, (2000) (PubMed).

Breitbart, Liang, Smoot, Laheru, Mahdavi, Nadal-Ginard: "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage." in: Development (Cambridge, England), Vol. 118, Issue 4, pp. 1095-106, (1994) (PubMed).

Martin, Miano, Hustad, Copeland, Jenkins, Olson: "A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing." in: Molecular and cellular biology, Vol. 14, Issue 3, pp. 1647-56, (1994) (PubMed).

Details zu MEF2D

Target: MEF2D (Myocyte Enhancer Factor 2D (MEF2D))

Andere Bezeichnung: MEF2D (MEF2D Produkte)

Synonyme: sl1 antikoerper, sl-1 antikoerper, XMEF2D antikoerper, MGC145245 antikoerper, C80750 antikoerper, myocyte enhancer factor 2D antikoerper, MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) antikoerper, mef2d antikoerper, MEF2D antikoerper, Mef2d antikoerper

Hintergrund: MEF2D is a member of the MEF2 (Myocyte-specific Enhancer-binding Factor 2) transcription factor family. Members of this family (MEF2A, B, C, & D) contain several characteristic motifs that include a MEF2 domain and a MADS box. MEF2 proteins bind the DNA sequence, 5'- (C/T)T(A/T)(A/T)AAATA(A/G)-3', and binding occurs primarily, although not exclusively, in muscle cells. MEF2D gene expression is ubiquitous and the mRNA is alternatively spliced. This results in multiple protein isoforms that heterodimerize with other family members. In addition to the MEF2 and MADS domains, MEF2D has a glutamine-/proline-rich region, amino acids 365-404, and a basic region, in the MADS domain near the N-terminus. The glutamine-/proline-rich region is involved in transactivation, while the basic region mediates sequence-specific DNA binding. MEF2D displays 75% similarity to hMEF2A and hMEF2C. Myogenin gene transcription requires MEF2D, indicating that MEF2D is involved in myogenesis and muscle cell differentiation. MEF2D has been reported to have a calculated molecular weight of 56 kD, but can be observed migrating in a range of 56-70 kD.
Synonyms: Myocyte-specific Enhancer-binding Factor 2

Molekulargewicht: 56-70 kDa