anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Antikörper

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. Zusätzlich bieten wir Ihnen Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MLL 4297 Q03164
MLL 214162 P55200
MLL 315606  
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Top anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antikörper auf antikoerper-online.de

Showing 10 out of 52 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Maus Unkonjugiert IHC, ELISA, WB Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and esophagus cancer (right), showing nuclear weak staining with DAB staining using MLL mouse mAb. Figure 2: Western blot analysis using MLL mouse mAb against truncated MLL recombinant protein (1) and truncated GFP-MLL (aa3714-3969) transfected Cos7 cell lysate (2) . 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
453,56 €
Details
Human Kaninchen Unkonjugiert ChIPSeq, ChIP, ICC, IF, WB MLL / HRX antibody (pAb) tested by ChIP-Seq. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 ug of chromatin from HeLa cells and 4 µg of antibody. ChIP DNA was sequenced on the Illumina HiSeq and 20 million sequence tags were mapped to identify MLL / HRX binding sites. The image shows binding across a region of chromosome 12. You can view the complete data set in the UCSC Genome Browser, starting at this specific location, here. MLL / HRX antibody (pAb) tested by Immunofluorescence. Formaldehyde fixed HeLa cells stained with MLL / HRX antibody at a 0.5 µg/ml dilution. 100 μg Anmelden zum Anzeigen 1 bis 3 Tage
508,33 €
Details
Human Kaninchen Unkonjugiert FACS, IHC (p) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Maus Unkonjugiert EIA, IHC (p), WB 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
440,00 €
Details
Human Maus Unkonjugiert ChIP, IP, WB   100 μg Anmelden zum Anzeigen 1 bis 3 Tage
497,22 €
Details
Human Maus Unkonjugiert IHC, WB 0.1 mL Anmelden zum Anzeigen 6 bis 8 Tage
440,00 €
Details
Human Kaninchen Unkonjugiert IHC, ELISA 0.05 mg Anmelden zum Anzeigen 6 bis 8 Tage
538,22 €
Details
Human Kaninchen Unkonjugiert IHC (p), ELISA 50 μg Anmelden zum Anzeigen 8 bis 10 Tage
456,00 €
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL Anmelden zum Anzeigen 7 bis 8 Tage
241,60 €
Details

MLL Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Rat (Rattus)


Am meisten referenzierte anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antikörper

  1. Human Polyclonal MLL Primary Antibody für EIA, IHC (p) - ABIN356674 : Megonigal, Cheung, Rappaport, Nowell, Wilson, Jones, Addya, Leonard, Kushner, Williams, Lange, Felix: Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Zeige alle 5 Referenzen für 356674

  2. Human Polyclonal MLL Primary Antibody für ChIPSeq, ChIP - ABIN2668494 : Ahmad, Katryniok, Scholz, Merkens, Löscher, Marschalek, Steinhilber: Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL. in Oncogenesis 2014 (PubMed)
    Zeige alle 5 Referenzen für 2668494

  3. Human Monoclonal MLL Primary Antibody für IHC, ELISA - ABIN969286 : Nigro, Sainati, Leszl, Mirabile, Spinelli, Consarino, Di Cataldo, Magro, Felix, Basso: Acute differentiated dendritic cell leukemia: a variant form of pediatric acute myeloid leukemia with MLL translocation. in Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007 (PubMed)
    Zeige alle 3 Referenzen für 969286

  4. Human Monoclonal MLL Primary Antibody für ChIP, IP - ABIN2668648 : Jin, Zhao, Yi, Nakata, Kalota, Gewirtz: c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. in The Journal of clinical investigation 2010 (PubMed)
    Zeige alle 2 Referenzen für 2668648

  5. Human Monoclonal MLL Primary Antibody für EIA, IHC (p) - ABIN1108254 : Partida-Pérez, Domínguez, Sánchez-Corona, Castañeda-Cisneros, García-González, López-Cardona, Rivera: Constitutional duplication 11q23 de novo involving the MLL gene. in Genetic counseling (Geneva, Switzerland) 2006 (PubMed)
    Zeige alle 2 Referenzen für 1108254

Weitere Antikörper gegen Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Interaktionspartner

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaktionspartner

  1. MLL rearrangement is associated with infant acute lymphoblastic leukemia.

  2. These results reveal a cooperative transcriptional activation mechanism of AEP (zeige LGMN Antikörper) and DOT1L (zeige DOT1L Antikörper) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (zeige DOT1L Antikörper) for more effective treatment of MLL-rearranged leukemia.

  3. this indicates that DOT1L (zeige DOT1L Antikörper) function, like MLL, does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L (zeige DOT1L Antikörper) inhibition is sufficient to block the proliferation of MLL fusion-induced leukemia cells of murine and human origin

  4. Studies demonstrate that histone methyl-transferase MLL1 coordinates with HIF1alpha (zeige HIF1A Antikörper) and histone acetyltransferase p300 (zeige EP300 Antikörper) and regulate hypoxia-induced HOTAIR expression. The hypoxia-induced upregulation of HOTAIR expression may contribute to its roles in tumorigenesis.

  5. MLL1 and MLL2 (zeige MLL2 Antikörper) collaborate to regulate gene expression and leukemia maintenance not through redundancy, but through distinct pathways.

  6. MLL1, deposits H3K4me2 at CpG-dense regions that could serve as polycomb (zeige CBX2 Antikörper) response elements.

  7. A patient was diagnosed with Wiedemann-Steiner syndrome based on identification of a novel de novo pathogenic variant in the KMT2A gene.

  8. MLL gene rearrangement is associated with acute lymphocytic leukemia.

  9. Our data thus extend MLL1 function to H3K4 methylation and PD-L1 (zeige CD274 Antikörper) transcription activation in pancreatic cancer cells.

  10. KMT2A gene rearrangement is associated with acute megakaryoblastic leukemia in non-Down syndrome.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaktionspartner

  1. These results reveal a cooperative transcriptional activation mechanism of AEP (zeige LGMN Antikörper) and DOT1L (zeige DOT1L Antikörper) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (zeige DOT1L Antikörper) for more effective treatment of MLL-rearranged leukemia.

  2. This study demonstrated that Kmt2a regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.

  3. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.

  4. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  5. HoxBlinc RNA Recruits Set1 (zeige SETD1A Antikörper)/MLL Complexes to Activate Hox (zeige MSH2 Antikörper) Gene Expression Patterns and Mesoderm Lineage Development.

  6. MLL1 and DOT1L (zeige DOT1L Antikörper) cooperate with meningioma-1 to induce acute myeloid leukemia (zeige BCL11A Antikörper).

  7. Set1 (zeige SETD1A Antikörper) role in cellular reprogramming and its interactions with Dpy30 (zeige DPY30 Antikörper),Myc (zeige MYC Antikörper),Sox2 (zeige SOX2 Antikörper) and Ash2l (zeige ASH2L Antikörper) reprogramming factors

  8. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model.

  9. We have demonstrated that the Mll1 gene is critical to Th1 (zeige HAND1 Antikörper) differentiation in humans and mice

  10. MLL is the key Taspase1 substrate whose cleavage is required for MMTV-neuinduced tumor formation.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Antigen-Profil

Protein Überblick

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit MLL

  • lysine (K)-specific methyltransferase 2A (KMT2A) Antikörper
  • lysine (K)-specific methyltransferase 2A (Kmt2a) Antikörper
  • 6430520K01 Antikörper
  • ALL-1 Antikörper
  • All1 Antikörper
  • Cxxc7 Antikörper
  • HRX Antikörper
  • HTRX1 Antikörper
  • mKIAA4050 Antikörper
  • Mll Antikörper
  • MLL/GAS7 Antikörper
  • Mll1 Antikörper
  • MLL1A Antikörper
  • TET1-MLL Antikörper
  • TRX1 Antikörper
  • WDSTS Antikörper

Bezeichner auf Proteinebene für MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPEZIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
Ausgewählte Anbieter für anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Antikörper
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