anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Antikörper

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. Zusätzlich bieten wir Ihnen Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MLL 4297 Q03164
MLL 214162 P55200
MLL 315606  
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Top anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antikörper auf antikoerper-online.de

Showing 10 out of 54 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Maus Unkonjugiert IHC, ELISA, WB Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and esophagus cancer (right), showing nuclear weak staining with DAB staining using MLL mouse mAb. Figure 2: Western blot analysis using MLL mouse mAb against truncated MLL recombinant protein (1) and truncated GFP-MLL (aa3714-3969) transfected Cos7 cell lysate (2) . 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$393.80
Details
Human Kaninchen Unkonjugiert ChIPSeq, ChIP, ICC, IF, WB MLL / HRX antibody (pAb) tested by ChIP-Seq. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with 30 ug of chromatin from HeLa cells and 4 µg of antibody. ChIP DNA was sequenced on the Illumina HiSeq and 20 million sequence tags were mapped to identify MLL / HRX binding sites. The image shows binding across a region of chromosome 12. You can view the complete data set in the UCSC Genome Browser, starting at this specific location, here. MLL / HRX antibody (pAb) tested by Immunofluorescence. Formaldehyde fixed HeLa cells stained with MLL / HRX antibody at a 0.5 µg/ml dilution. 100 μg Anmelden zum Anzeigen 1 bis 2 Tage
$507.50
Details
Human Kaninchen Unkonjugiert FACS, IHC (p) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert IHC, WB Western blot analysis of extracts of various cell lines, using KMT2A antibody. 100 μL Anmelden zum Anzeigen 16 Days
$391.88
Details
Human Maus Unkonjugiert EIA, IHC (p), WB 0.1 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Maus Unkonjugiert ChIP, IP, WB   100 μg Anmelden zum Anzeigen 1 bis 2 Tage
$495.83
Details
Human Maus Unkonjugiert IHC, WB 0.1 mL Anmelden zum Anzeigen 2 bis 3 Tage
$412.50
Details
Human Kaninchen Unkonjugiert WB   200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA 0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$515.63
Details

MLL Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Rat (Rattus)


Am meisten referenzierte anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antikörper

  1. Human Polyclonal MLL Primary Antibody für IHC - ABIN966301 : Tkachuk, Kohler, Cleary: Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. in Cell 1992 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal MLL Primary Antibody für ChIPSeq, ChIP - ABIN2668494 : Ahmad, Katryniok, Scholz, Merkens, Löscher, Marschalek, Steinhilber: Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL. in Oncogenesis 2014 (PubMed)
    Show all 5 Pubmed References

  3. Human Polyclonal MLL Primary Antibody für - ABIN966302 : Nilson, Löchner, Siegler, Greil, Beck, Fey, Marschalek: Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias. in British journal of haematology 1996 (PubMed)
    Show all 4 Pubmed References

  4. Human Monoclonal MLL Primary Antibody für IHC, ELISA - ABIN969286 : Nigro, Sainati, Leszl, Mirabile, Spinelli, Consarino, Di Cataldo, Magro, Felix, Basso: Acute differentiated dendritic cell leukemia: a variant form of pediatric acute myeloid leukemia with MLL translocation. in Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal MLL Primary Antibody für ChIP, IP - ABIN2668648 : Jin, Zhao, Yi, Nakata, Kalota, Gewirtz: c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. in The Journal of clinical investigation 2010 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal MLL Primary Antibody für ELISA, IHC - ABIN2869284 : Partida-Pérez, Domínguez, Sánchez-Corona, Castañeda-Cisneros, García-González, López-Cardona, Rivera: Constitutional duplication 11q23 de novo involving the MLL gene. in Genetic counseling (Geneva, Switzerland) 2006 (PubMed)
    Show all 4 Pubmed References

Weitere Antikörper gegen Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Interaktionspartner

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaktionspartner

  1. Identification of novel biomarkers for MLL-translocated acute myeloid leukemia (zeige BCL11A Antikörper).

  2. Collectively, these data indicated that ATR (zeige ANTXR1 Antikörper) or ATM (zeige ATM Antikörper) inhibition represent potential therapeutic strategies for the treatment of AML (zeige RUNX1 Antikörper), especially MLL-driven leukemias.

  3. we report two boys with novel KMT2A mutations from Chinese origin for the first time. They do not show one of the characteristic WDSTS phenotype, cubiti hypertrichosis. Instead, both of them had absent palmar proximal transverse crease. The feature was not linked to WDSTS patients previously. Our findings extend the WDSTS phenotypic spectrum.

  4. Whole exome sequencing allowed identifying a previously unreported de novo KMT2A missense mutation affecting the DNA binding domain of the methyltransferase. This finding expands the clinical phenotype associated with KMT2A mutations to include immunodeficiency and epilepsy as clinically relevant features for this disorder.

  5. MLL rearrangement is associated with infant acute lymphoblastic leukemia.

  6. These results reveal a cooperative transcriptional activation mechanism of AEP (zeige LGMN Antikörper) and DOT1L (zeige DOT1L Antikörper) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (zeige DOT1L Antikörper) for more effective treatment of MLL-rearranged leukemia.

  7. this indicates that DOT1L (zeige DOT1L Antikörper) function, like MLL, does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L (zeige DOT1L Antikörper) inhibition is sufficient to block the proliferation of MLL fusion-induced leukemia cells of murine and human origin

  8. Studies demonstrate that histone methyl-transferase MLL1 coordinates with HIF1alpha (zeige HIF1A Antikörper) and histone acetyltransferase p300 (zeige EP300 Antikörper) and regulate hypoxia-induced HOTAIR expression. The hypoxia-induced upregulation of HOTAIR expression may contribute to its roles in tumorigenesis.

  9. MLL1 and MLL2 (zeige MLL2 Antikörper) collaborate to regulate gene expression and leukemia maintenance not through redundancy, but through distinct pathways.

  10. MLL1, deposits H3K4me2 at CpG-dense regions that could serve as polycomb (zeige CBX2 Antikörper) response elements.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaktionspartner

  1. Collectively, these data indicated that ATR (zeige ATR Antikörper) or ATM (zeige ATM Antikörper) inhibition represent potential therapeutic strategies for the treatment of AML (zeige RUNX1 Antikörper), especially MLL-driven leukemias.

  2. Epigenomic profiling indicates an abnormal H3K79me2 pattern on MLL-fusion targeted genes, but the molecular mechanism underlying this epigenetic dependency is not well understood.

  3. NUP98 (zeige NUP98 Antikörper)-HOXA9 (zeige HOXA9 Antikörper) interacts with MLL via the NUP98 (zeige NUP98 Antikörper) second FG repeat domain. In the absence of MLL (in knockout mice), NUP98 (zeige NUP98 Antikörper)-HOXA9 (zeige HOXA9 Antikörper)-induced cell immortalization and leukemogenesis are severely inhibited. MLL is important for the recruitment of NUP98 (zeige NUP98 Antikörper)-HOXA9 (zeige HOXA9 Antikörper) to the HOXA locus and for NUP98 (zeige NUP98 Antikörper)-HOXA9 (zeige HOXA9 Antikörper)-induced HOXA gene expression. MLL is crucial for NUP98 (zeige NUP98 Antikörper)-HOXA9 (zeige HOXA9 Antikörper) leukemia initiation.

  4. Atg5 (zeige ATG5 Antikörper)-dependent autophagy contributes to the development of acute myeloid leukemia (zeige BCL11A Antikörper) in an MLL-AF9 (zeige MLLT3 Antikörper)-driven mouse model.

  5. These results reveal a cooperative transcriptional activation mechanism of AEP (zeige LGMN Antikörper) and DOT1L (zeige DOT1L Antikörper) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (zeige DOT1L Antikörper) for more effective treatment of MLL-rearranged leukemia.

  6. This study demonstrated that Kmt2a regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.

  7. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.

  8. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  9. HoxBlinc RNA Recruits Set1 (zeige SETD1A Antikörper)/MLL Complexes to Activate Hox (zeige MSH2 Antikörper) Gene Expression Patterns and Mesoderm Lineage Development.

  10. MLL1 and DOT1L (zeige DOT1L Antikörper) cooperate with meningioma-1 to induce acute myeloid leukemia (zeige BCL11A Antikörper).

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Antigen-Profil

Protein Überblick

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit MLL

  • lysine methyltransferase 2A (KMT2A) Antikörper
  • lysine (K)-specific methyltransferase 2A (Kmt2a) Antikörper
  • lysine methyltransferase 2A (Kmt2a) Antikörper
  • 6430520K01 Antikörper
  • ALL-1 Antikörper
  • All1 Antikörper
  • Cxxc7 Antikörper
  • HRX Antikörper
  • HTRX1 Antikörper
  • mKIAA4050 Antikörper
  • Mll Antikörper
  • MLL/GAS7 Antikörper
  • Mll1 Antikörper
  • MLL1A Antikörper
  • TET1-MLL Antikörper
  • TRX1 Antikörper
  • WDSTS Antikörper

Bezeichner auf Proteinebene für MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPEZIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
Ausgewählte Anbieter für anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Antikörper
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