anti-Mycn (MYCN) Antikörper

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Zusätzlich bieten wir Ihnen MYCN Proteine (10) und MYCN Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MYCN 4613 P04198
MYCN 298894 Q63379
MYCN 18109 P03966
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Top anti-MYCN Antikörper auf antikoerper-online.de

Showing 10 out of 97 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
315,94 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
288,68 €
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
340,48 €
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of MYCN antibody (C-term) (ABIN391590) in CEM cell line lysates (35 µg/lane). MYCN (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of MYCN antibody (C-term) in CEM cell line lysates (35ug/lane). MYCN (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Maus Unkonjugiert ChIP, CyTOF, FACS, GS, ICC, IF, IP, WB Immunocytochemistry/ Immunofluorescence: n-Myc Antibody (NMYC-1) [ABIN152254] - The n-Myc (NMYC-1) antibody was tested in NTERA2 cells at a 1:50 dilution against Dylight 488 (Green). Actin and nuclei were counterstained against Phalloidin 568 (Red) and DAPI (Blue), respectively. Western Blot: n-Myc Antibody (NMYC-1) [ABIN152254] - Western blot analysis of n-Myc expression in human heart tissue. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
311,00 €
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
583,17 €
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Maus Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB   0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
410,00 €
Details
Human Maus Unkonjugiert WB Western Blot analysis of MYCN expression in transfected 293T cell line by MYCN monoclonal antibody (M01), clone 3H4. Lane 1: MYCN transfected lysate(49.6 KDa). Lane 2: Non-transfected lysate. Western blot analysis of MYCN over-expressed 293 cell line, cotransfected with MYCN Validated Chimera RNAi used as specificity and loading control. 0.1 mg Anmelden zum Anzeigen 12 bis 16 Tage
454,76 €
Details
Human Maus Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
635,55 €
Details

MYCN Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-MYCN Antikörper

  1. Human Monoclonal MYCN Primary Antibody für ChIP, CyTOF - ABIN152254 : Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. in The Journal of biological chemistry 2011 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal MYCN Primary Antibody für ICC, IF - ABIN256650 : Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. in Developmental cell 2005 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal MYCN Primary Antibody für WB - ABIN391590 : Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. in Molecular cancer research : MCR 2015 (PubMed)

  4. Human Polyclonal MYCN Primary Antibody für IF (p), IHC (p) - ABIN760676 : Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. in Oncotarget 2016 (PubMed)

Weitere Antikörper gegen MYCN Interaktionspartner

Human Mycn (MYCN) Interaktionspartner

  1. Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (zeige RB1 Antikörper) gene.

  2. USP7 (zeige USP7 Antikörper) deubiquitinates MYCN to enhance its stability and transcriptional activity in neuroblastoma (zeige ARHGEF16 Antikörper).

  3. The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (zeige ARHGEF16 Antikörper), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (zeige ARHGEF16 Antikörper).

  4. Many prognostic signatures for neuroblastoma (zeige ARHGEF16 Antikörper) are confounded by MYCN amplification.

  5. Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.

  6. miR (zeige MLXIP Antikörper)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (zeige CADM1 Antikörper), and an inverse correlation between miR (zeige MLXIP Antikörper)-21 and CADM1 (zeige CADM1 Antikörper) expression in vivo. MiR (zeige MLXIP Antikörper)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer

  7. LMO1 (zeige LMO1 Antikörper) is an important oncogene (zeige RAB1A Antikörper) that promotes neuroblastoma (zeige ARHGEF16 Antikörper) initiation, progression, and widespread metastatic dissemination.

  8. our results identify DOT1L (zeige DOT1L Antikörper) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (zeige ARHGEF16 Antikörper) oncogenesis. Furthermore, they characterize DOT1L (zeige DOT1L Antikörper) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (zeige ARHGEF16 Antikörper).

  9. CCCTC-binding factor (CTCF (zeige CTCF Antikörper)) targets the binding sites within MYCN promoter to facilitate its expression in neuroblastoma (zeige ARHGEF16 Antikörper) (NB) cells.

  10. PAX3 (zeige PAX3 Antikörper)-FOXO1 (zeige FOXO1 Antikörper) collaborates with MYCN during early rhabdomyosarcoma (RMS) tumourigenesis to dysregulate proliferation and inhibit myogenic differentiation and cell death.

Mouse (Murine) Mycn (MYCN) Interaktionspartner

  1. the role of N-myc in mouse lens development, was examined.

  2. Using comparative genomic hybridization, authors found that NCC (zeige SLC12A3 Antikörper)-derived NBL (zeige NUMBL Antikörper) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (zeige NUMBL Antikörper) including 17q gain, 2p gain and loss of 1p36.

  3. a Mycn target gene encoding the miR (zeige MLXIP Antikörper) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  4. The findings reveal a PLK1 (zeige PLK1 Antikörper)-Fbw7 (zeige FBXW7 Antikörper)-Myc (zeige MYC Antikörper) signaling circuit that underlies tumorigenesis and validate PLK1 (zeige PLK1 Antikörper) inhibitors, alone or with Bcl2 (zeige BCL2 Antikörper) antagonists, as potential effective therapeutics for MYC (zeige MYC Antikörper)-overexpressing cancers.

  5. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (zeige MMRN1 Antikörper)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  6. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

  7. Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma (zeige ARHGEF16 Antikörper), and is a promising approach for further clinical development.

  8. demonstrate a critical link between Myc (zeige MYC Antikörper)/Mycn gene activity and glycolysis in spermatogonial stem cell self-renewal

  9. Loss of N-myc significantly impairs the Sonic hedgehog (zeige SHH Antikörper) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (zeige CCND2 Antikörper).

  10. Study shows that ground-state embryonic stem cells express low Myc (zeige MYC Antikörper) levels. Deletion of both c-myc (zeige MYC Antikörper) and N-myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest; process is reversible and occurs without affecting pluripotency, suggesting that Myc (zeige MYC Antikörper)-depleted stem cells enter a state of dormancy.

MYCN Antigen-Profil

Protein Überblick

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Genbezeichner und Symbole assoziert mit anti-Mycn (MYCN) Antikörper

  • olfactory receptor, family 8, subfamily S, member 1-like (LOC515887) Antikörper
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) Antikörper
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (Mycn) Antikörper
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (MYCN) Antikörper
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN) Antikörper
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (Mycn) Antikörper
  • bHLHe37 Antikörper
  • c-nmyc Antikörper
  • MODED Antikörper
  • MYCNOT Antikörper
  • N-myc Antikörper
  • Nmuc1 Antikörper
  • Nmyc Antikörper
  • Nmyc-1 Antikörper
  • Nmyc1 Antikörper
  • ODED Antikörper

Bezeichner auf Proteinebene für anti-Mycn (MYCN) Antikörper

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc protein , neuroblastoma myc-related oncogene 1

GENE ID SPEZIES
515887 Bos taurus
4613 Homo sapiens
298894 Rattus norvegicus
421948 Gallus gallus
482978 Canis lupus familiaris
18109 Mus musculus
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