anti-Mycn (MYCN) Antikörper

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Zusätzlich bieten wir Ihnen MYCN Proteine (7) und MYCN Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MYCN 4613 P04198
MYCN 18109 P03966
MYCN 298894 Q63379
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Top anti-MYCN Antikörper auf antikoerper-online.de

Showing 10 out of 98 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$318.45
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of MYCN antibody (C-term) (ABIN391590) in CEM cell line lysates (35 µg/lane). MYCN (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of MYCN antibody (C-term) in CEM cell line lysates (35ug/lane). MYCN (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Maus Unkonjugiert ChIP, CyTOF, FACS, GS, ICC, IF, IP, WB Immunocytochemistry/ Immunofluorescence: n-Myc Antibody (NMYC-1) [ABIN152254] - The n-Myc (NMYC-1) antibody was tested in NTERA2 cells at a 1:50 dilution against Dylight 488 (Green). Actin and nuclei were counterstained against Phalloidin 568 (Red) and DAPI (Blue), respectively. Western Blot: n-Myc Antibody (NMYC-1) [ABIN152254] - Western blot analysis of n-Myc expression in human heart tissue. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$444.19
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details
Human Kaninchen Unkonjugiert ELISA, WB The n-Myc Antibody is used in Western blot to detect Myc in human fetal kidney lysate. 0.1 mg Anmelden zum Anzeigen 2 bis 6 Tage
$327.00
Details
Human Maus Unkonjugiert WB Western Blot analysis of MYCN expression in transfected 293T cell line by MYCN monoclonal antibody (M01), clone 3H4. Lane 1: MYCN transfected lysate(49.6 KDa). Lane 2: Non-transfected lysate. Western blot analysis of MYCN over-expressed 293 cell line, cotransfected with MYCN Validated Chimera RNAi used as specificity and loading control. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Maus Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$537.17
Details

MYCN Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-MYCN Antikörper

  1. Human Monoclonal MYCN Primary Antibody für ChIP, CyTOF - ABIN152254 : Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. in The Journal of biological chemistry 2011 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal MYCN Primary Antibody für ICC, IF - ABIN256650 : Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. in Developmental cell 2005 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal MYCN Primary Antibody für IF (p), IHC (p) - ABIN760676 : Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. in Oncotarget 2016 (PubMed)

  4. Human Polyclonal MYCN Primary Antibody für WB - ABIN391590 : Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. in Molecular cancer research : MCR 2015 (PubMed)

Weitere Antikörper gegen MYCN Interaktionspartner

Human Mycn (MYCN) Interaktionspartner

  1. data extend knowledge on roles of MCPIP1 (zeige ZC3H12A Antikörper) in our model and link the protein to regulation of expression and stability of MYCN through decrease of signaling via Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) pathway.

  2. Data show that MYCN and its regulated microRNAs acted together to repress the tumor suppressor genes.

  3. Common genetic variation predisposes to different neuroblastoma (zeige ARHGEF16 Antikörper) genotypes, including the likelihood of somatic MYCN-amplification. [meta-analysis]

  4. Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (zeige RB1 Antikörper) gene.

  5. The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (zeige ARHGEF16 Antikörper), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (zeige ARHGEF16 Antikörper).

  6. Many prognostic signatures for neuroblastoma (zeige ARHGEF16 Antikörper) are confounded by MYCN amplification.

  7. Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.

  8. miR (zeige MLXIP Antikörper)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (zeige CADM1 Antikörper), and an inverse correlation between miR (zeige MLXIP Antikörper)-21 and CADM1 (zeige CADM1 Antikörper) expression in vivo. MiR (zeige MLXIP Antikörper)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer

  9. LMO1 (zeige LMO1 Antikörper) is an important oncogene (zeige RAB1A Antikörper) that promotes neuroblastoma (zeige ARHGEF16 Antikörper) initiation, progression, and widespread metastatic dissemination.

  10. our results identify DOT1L (zeige DOT1L Antikörper) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (zeige ARHGEF16 Antikörper) oncogenesis. Furthermore, they characterize DOT1L (zeige DOT1L Antikörper) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (zeige ARHGEF16 Antikörper).

Mouse (Murine) Mycn (MYCN) Interaktionspartner

  1. interactions of NF-kappaB (zeige NFKB1 Antikörper) and N-myc with GLT-1/EAAT2 (zeige SLC1A2 Antikörper) promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice.

  2. beta-catenin (zeige CTNNB1 Antikörper) cooperates with the transcription factor Myc (zeige MYC Antikörper) to activate the progenitor renewal program.

  3. we report the isolation and propagation of neuroblastoma (zeige ARHGEF16 Antikörper) sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma (zeige ARHGEF16 Antikörper) with MYCN amplification

  4. miR (zeige MLXIP Antikörper)-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.

  5. the role of N-myc in mouse lens development, was examined.

  6. Using comparative genomic hybridization, authors found that NCC (zeige SLC12A3 Antikörper)-derived NBL (zeige NUMBL Antikörper) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (zeige NUMBL Antikörper) including 17q gain, 2p gain and loss of 1p36.

  7. a Mycn target gene encoding the miR (zeige MLXIP Antikörper) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  8. The findings reveal a PLK1 (zeige PLK1 Antikörper)-Fbw7 (zeige FBXW7 Antikörper)-Myc (zeige MYC Antikörper) signaling circuit that underlies tumorigenesis and validate PLK1 (zeige PLK1 Antikörper) inhibitors, alone or with Bcl2 (zeige BCL2 Antikörper) antagonists, as potential effective therapeutics for MYC (zeige MYC Antikörper)-overexpressing cancers.

  9. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (zeige MMRN1 Antikörper)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  10. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

Zebrafish Mycn (MYCN) Interaktionspartner

  1. In MYCN transgenic fish, Gab2 (zeige GAB2 Antikörper) overexpression activated the Shp2 (zeige PTPN11 Antikörper)-Ras (zeige RAB1A Antikörper)-Erk (zeige MAPK1 Antikörper) pathway, enhanced neuroblastoma (zeige ARHGEF16 Antikörper) induction, and increased tumor penetrance.

  2. The authors demonstrate in zebrafish that nf1 (zeige NF1 Antikörper) loss leads to aberrant activation of RAS (zeige RAB1A Antikörper) signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma (zeige ARHGEF16 Antikörper) in nf1 (zeige NF1 Antikörper)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (zeige NF1 Antikörper) mutant embryos.

  3. At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.

MYCN Antigen-Profil

Protein Überblick

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Genbezeichner und Symbole assoziert mit anti-Mycn (MYCN) Antikörper

  • MYCN proto-oncogene, bHLH transcription factor (MYCN) Antikörper
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) Antikörper
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor (Mycn) Antikörper
  • olfactory receptor 8S1 (LOC515887) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor (mycn) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S) Antikörper
  • bHLHe37 Antikörper
  • c-nmyc Antikörper
  • fb57a02 Antikörper
  • MODED Antikörper
  • mycn Antikörper
  • mycn-a Antikörper
  • mycn-b Antikörper
  • mycna Antikörper
  • MYCNOT Antikörper
  • N-myc Antikörper
  • Nmuc1 Antikörper
  • Nmyc Antikörper
  • Nmyc-1 Antikörper
  • nmyc1 Antikörper
  • ODED Antikörper
  • wu:fb57a02 Antikörper
  • XN-myc Antikörper
  • xN-myc1 Antikörper
  • XNmyc Antikörper
  • zgc:85706 Antikörper

Bezeichner auf Proteinebene für anti-Mycn (MYCN) Antikörper

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPEZIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
Ausgewählte Anbieter für anti-MYCN (MYCN) Antikörper
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