Melanophilin (MLPH) ELISA Kits

MLPH encodes a member of the exophilin subfamily of Rab effector proteins. Zusätzlich bieten wir Ihnen Melanophilin Antikörper (59) und Melanophilin Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
MLPH 171531 Q91V27
Anti-Ratte MLPH MLPH 316620  
MLPH 79083 Q9BV36
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Top Melanophilin ELISA Kits auf antikoerper-online.de

Showing 3 out of 3 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 78-5000 pg/mL   96 Tests Anmelden zum Anzeigen 6 bis 8 Tage
679,90 €
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Human
78-5000 pg/mL   96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
Details
Maus
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
Details

Weitere ELISA Kits für Melanophilin Interaktionspartner

Cow (Bovine) Melanophilin (MLPH) Interaktionspartner

  1. a frameshifting deletion in the melanophilin gene accounts for a distinctive coat color in Belgian Blue cattle

Rabbit Melanophilin (MLPH) Interaktionspartner

  1. A frameshift mutation within MLPH is responsible for the dilution of both eumelanic and pheomelanic pigmentations in rabbits.

  2. Two-exon skipping within MLPH is associated with coat color dilution in rabbits.

Mouse (Murine) Melanophilin (MLPH) Interaktionspartner

  1. The results showed that Rab27A (zeige RAB27A ELISA Kits)(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A (zeige RAB27A ELISA Kits) effector Slac2-a/melanophilin.

  2. Data show at the single-molecule level that melanophilin (Mlph) increases the number of processively moving myoVa (zeige MYO5A ELISA Kits) motors by 17-fold.

  3. Data suggest that Rab27a (zeige RAB27A ELISA Kits) and Rab27b (zeige RAB27B ELISA Kits) regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a (zeige RAB27A ELISA Kits)/Mlph/MyoVa (zeige MYO5A ELISA Kits) regulating cortical actin stability upstream of Rab27a/b (zeige RAB27A ELISA Kits)/Munc13-4 (zeige UNC13D ELISA Kits)-dependent granule exocytosis.

  4. Slac2-a/melanophilin contains an N-terminal Slp (zeige SEPT9 ELISA Kits) homology domain (SHD) (PMID: 11327731). The SHD of Slac2-a specifically and directly binds the GTP (zeige AK3 ELISA Kits)-bound form of Rab27A (zeige RAB27A ELISA Kits) and Rab27B (zeige RAB27B ELISA Kits) (PMID: 11773082). The C-terminal domain directly binds myosin Va.

  5. The leaden gene product is required with Rab27a (zeige RAB27A ELISA Kits) to recruit myosin Va (zeige MYO5A ELISA Kits) to melanosomes in melanocytes

  6. myosin Va (zeige MYO5A ELISA Kits) binds to melanophilin and Rab27a (zeige RAB27A ELISA Kits)

  7. Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va (zeige MYO5A ELISA Kits) to melanosomes

  8. SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP (zeige AK3 ELISA Kits)-bound form of Rab27A (zeige RAB27A ELISA Kits)

  9. Slac2-a organizes actin-based melanosome transport in cooperation with Rab27A, myosin Va, and actin

  10. cAMP stimulates the expression of Rab27a (zeige RAB27A ELISA Kits) and rapidly increases the interaction of the melanophilin/Slac2-a with actin

Human Melanophilin (MLPH) Interaktionspartner

  1. These results unravel a hidden link between AR and a functional putative PCa (zeige FLVCR1 ELISA Kits) risk SNP, whose allele alteration affects androgen regulation of its host gene MLPH.

  2. The results showed that Rab27A (zeige RAB27A ELISA Kits)(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A (zeige RAB27A ELISA Kits) effector Slac2-a/melanophilin.

  3. The pathologic defect in Griscelli syndrome 3 came from the MLPH R35W substitution, which induced aggregation of melanosomes in the perinuclear area of melanocytes because of failure to interact with RAB27A (zeige RAB27A ELISA Kits).

  4. Slac2-a/melanophilin contains an N-terminal Slp (zeige SEPT9 ELISA Kits) homology domain (SHD) (PMID: 11327731). The SHD of Slac2-a specifically and directly binds the GTP (zeige AK3 ELISA Kits)-bound form of Rab27A (zeige RAB27A ELISA Kits) and Rab27B (zeige RAB27B ELISA Kits) (PMID: 11773082). The C-terminus of Slac2-a directly binds myosin Va (zeige MYO5A ELISA Kits).

  5. links rab27a (zeige RAB27A ELISA Kits) and myosin Va (zeige MYO5A ELISA Kits) function in melanosome transport

  6. Melanophilin has a role in bridging Rab27a on melanosomes and myosin Va on actin filaments during melanosome transport.

  7. SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP (zeige AK3 ELISA Kits)-bound form of Rab27A (zeige RAB27A ELISA Kits)

  8. Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A (zeige MYO5A ELISA Kits) F-exon deletion (GS1 (zeige MYO5A ELISA Kits)).

  9. The C-terminus of Slac2-a/melanophilin contains a novel actin-binding site, which may be involved in capture of Rab27 (zeige RAB27A ELISA Kits)-containing organelles in the actin-enriched cell periphery.

Melanophilin (MLPH) Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Genbezeichner und Symbole assoziert mit Melanophilin (MLPH) ELISA Kits

  • melanophilin (MLPH) Antikörper
  • melanophilin (mlph) Antikörper
  • melanophilin (LOC100222096) Antikörper
  • melanophilin (LOC100343360) Antikörper
  • melanophilin (Mlph) Antikörper
  • 2210418F23Rik Antikörper
  • 5031433I09Rik Antikörper
  • AW228792 Antikörper
  • D1Wsu84e Antikörper
  • l(1)-3Rk Antikörper
  • l1Rk3 Antikörper
  • ln Antikörper
  • LOC100222096 Antikörper
  • MGC155106 Antikörper
  • Slac-2a Antikörper
  • SLAC2-A Antikörper

Bezeichner auf Proteinebene für Melanophilin (MLPH) ELISA Kits

melanophilin , exophilin-3 , leaden protein , slaC2-a , slp homolog lacking C2 domains a , synaptotagmin-like protein 2a

GENE ID SPEZIES
424019 Gallus gallus
460048 Pan troglodytes
531343 Bos taurus
607077 Canis lupus familiaris
780791 Felis catus
100049680 Sus scrofa
100066385 Equus caballus
100145236 Xenopus (Silurana) tropicalis
100222096 Taeniopygia guttata
100272215 Ovis aries
100343360 Oryctolagus cuniculus
100590922 Nomascus leucogenys
171531 Mus musculus
316620 Rattus norvegicus
79083 Homo sapiens
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