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Melanophilin Produkte

(Melanophilin (MLPH))

Kategorien

This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].

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Ausgewählte Melanophilin Kategorien

Melanophilin Antikörper

High quality antibodies with extensive validation data.

Melanophilin ELISA Kits

Reliable ELISA kits for a wide range of species.

Melanophilin Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Melanophilin Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC, IF
Validierungen
  • (3)
Kat. Nr. ABIN7159304
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, IF
Validierungen
  • (3)
Kat. Nr. ABIN7262539
Menge 200 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, IHC
Validierungen
  • (3)
Kat. Nr. ABIN6263218
Menge 100 μL
Datenblatt Datenblatt

Empfohlene Melanophilin ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN5592380
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6205901
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Melanophilin Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1311024
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source Tobacco (Nicotiana tabacum)
Validierungen
  • (1)
Kat. Nr. ABIN3127249
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Tobacco (Nicotiana tabacum)
Validierungen
  • (1)
Kat. Nr. ABIN3083586
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Melanophilin Produkten

Sanzà, Evans, Briggs, Cantero, Montoliu, Patel, Sviderskaya, Itzen, Figueiredo, Seabra, Hume: "Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a." in: Journal of cell science, Vol. 132, Issue 9, (2020) (PubMed).

Zhan, Yan, Wang, Sun, Wang, Lin, Zhang, Shi, Jiang, Wang: "Identification of immunohistochemical markers for distinguishing lung adenocarcinoma from squamous cell carcinoma." in: Journal of thoracic disease, Vol. 7, Issue 8, pp. 1398-405, (2015) (PubMed).

Gromov, Espinoza, Talman, Honma, Kroman, Timmermans Wielenga, Moreira, Gromova: "FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast." in: PLoS ONE, Vol. 9, Issue 11, pp. e112024, (2014) (PubMed).

Singh, Mizuno, Wasmeier, Wavre-Shapton, Recchi, Catz, Futter, Tolmachova, Hume, Seabra: "Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion." in: The FEBS journal, Vol. 280, Issue 3, pp. 892-903, (2013) (PubMed).

Figueiredo, Wasmeier, Tarafder, Ramalho, Baron, Seabra: "Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes." in: The Journal of biological chemistry, Vol. 283, Issue 34, pp. 23209-16, (2008) (PubMed).

Hume, Tarafder, Ramalho, Sviderskaya, Seabra: "A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes." in: Molecular biology of the cell, Vol. 17, Issue 11, pp. 4720-35, (2006) (PubMed).

Hamza, Prohaska, Gitlin: "Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 3, pp. 1215-20, (2003) (PubMed).

Matesic, Yip, Reuss, Swing, OSullivan, Fletcher, Copeland, Jenkins: "Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 18, pp. 10238-43, (2001) (PubMed).

Adler, Fuchs, Kim, Kraft, King, Pelling, Ronai: "jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 6, Issue 11, pp. 1437-46, (1996) (PubMed).

Subramaniam, Peter, Philp, Wong, Hong: "GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport." in: Science (New York, N.Y.), Vol. 272, Issue 5265, pp. 1161-3, (1996) (PubMed).

Synonyme und alternative Namen zu Melanophilin

melanophilin (MLPH), melanophilin (mlph), melanophilin (Mlph), 2210418F23Rik, 5031433I09Rik, AW228792, D1Wsu84e, l(1)-3Rk, l1Rk3, ln, LOC100222096, MGC155106, Slac-2a, SLAC2-A

Bezeichner auf Proteinebene für Melanophilin

  • melanophilin
  • exophilin-3
  • leaden protein
  • slaC2-a
  • slp homolog lacking C2 domains a
  • synaptotagmin-like protein 2a
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