Matrilin 3 Proteine (MATN3)

MATN3 encodes a member of von Willebrand factor A domain containing protein family. Zusätzlich bieten wir Ihnen Matrilin 3 Antikörper (56) und Matrilin 3 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MATN3 4148 O15232
MATN3 17182 O35701
Ratte MATN3 MATN3 313954  
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.041,59 €
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MATN3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Matrilin 3 (MATN3) Interaktionspartnern

Human Matrilin 3 (MATN3) Interaktionspartner

  1. our results revealed miR (zeige MLXIP Proteine)-483-5p directly targeted to the cartilage matrix protein (zeige MATN1 Proteine) matrilin 3 (Matn3) and tissue inhibitor of metalloproteinase 2 (Timp2 (zeige TIMP2 Proteine)) to stimulate chondrocyte hypertrophy, extracellular matrix degradation, and cartilage angiogenesis, and it consequently initiated and accelerated the development of OA.

  2. The results of the study indicate a potential role for the MATN3 rs28598872 polymorphism in the pathogenesis of Temporomandibular Joint Internal Derangement.

  3. This report is the first to show the involvement of MATN3 in C-type natriuretic peptide/natriuretic peptide receptor-B signaling pathway during the process of transforming growth factor-beta induced chondrogenic differentiation of mesenchymal stem cells.

  4. MATN3 plays a regulatory role in cartilage homeostasis due to its capacity to induce IL-1Ra (zeige IL1RN Proteine), upregulate gene expression of major cartilage matrix components, and downregulate the expression of OA-associated matrix-degrading proteinases in chondrocytes.

  5. MATN3 may have the inherent ability to inhibit premature chondrocyte hypertrophy by suppressing BMP-2 (zeige BMP2 Proteine)/Smad1 (zeige GARS Proteine) activity

  6. The VWA1 (zeige VWA1 Proteine) domain of matrilin-3 is primarily responsible for the induction of IL-6 (zeige IL6 Proteine) release from primary human chondrocytes.

  7. Polymorphism in the MATN3 gene might play a role in osteoarthritis in the Chinese Han population.

  8. Haplotype-4 of MATN3 is associated with vertebral fracture risk independent of bone mineral density in Chinese postmenopausal women.

  9. MATN3 mutations were identified in 13 multiple epiphyseal dysplasia patients and comprised predominantly of missense mutations.

  10. Radiographic findings in patients with COMP (zeige COMP Proteine) and MATN3 mutations showed marked abnormalities in hip and knee joints.

Mouse (Murine) Matrilin 3 (MATN3) Interaktionspartner

  1. Data show that hand osteoarthritis (HOA)-related matrilin-3 mutation (T298M) leads to a high expression level of growth arrest DNA damage-inducible gene 153 (GADD153 (zeige DDIT3 Proteine))

  2. MATN3 plays a regulatory role in cartilage homeostasis due to its capacity to induce IL-1Ra (zeige IL1RN Proteine), upregulate gene expression of major cartilage matrix components, and downregulate the expression of OA-associated matrix-degrading proteinases in chondrocytes.

  3. MATN3 may have the inherent ability to inhibit premature chondrocyte hypertrophy by suppressing BMP-2 (zeige BMP2 Proteine)/Smad1 (zeige SMAD1 Proteine) activity

  4. study will facilitate better awareness of the differential diagnoses that might be associated with the PSACH (zeige COMP Proteine)/MED spectrum and subsequent care of PSACH (zeige COMP Proteine)/MED patients

  5. Lack of COMP (zeige COMP Proteine) and matrilin 3 leads to increased deposition of TIMP-3 (zeige TIMP3 Proteine), which causes partial inactivation of matrix metalloproteinases in bone, including MMP-13 (zeige MMP13 Proteine).

  6. Secretion of matrilin 3 V194D mutant protein is not dependent on hetero-oligomerization with matrilin 1 (zeige MATN1 Proteine).

  7. matrilin-3 mutation associated with osteoarthritis does not affect collagen affinity but promotes the formation of wider cartilage collagen (zeige COL2A1 Proteine) fibrils

  8. potential of matrilin-3 to modulate gene expression profile of primary chondrocytes; tested matrilin3-dependent induction of pro-inflammatory cytokines, inducible nitric oxide synthetase & cyclooxygenase-2 (zeige PTGS2 Proteine), MMP1 (zeige MMP1 Proteine), -3 & -13, & matrilin-3 itself

  9. Expression of matrilin-3 during maturation of mouse skeletal tissues

  10. To assess the function of matrilin-3 during skeletal development, we have generated Matn-3 null mice; phenotypes of multiple epiphyseal dysplasia disorders are not caused by the absence of matrilin-3 in cartilage ECM (zeige MMRN1 Proteine).

Cow (Bovine) Matrilin 3 (MATN3) Interaktionspartner

Matrilin 3 (MATN3) Protein Überblick

Protein Überblick

This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains\; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia.

Genbezeichner und Symbole assoziert mit Matrilin 3 Proteine (MATN3)

  • matrilin 3 (MATN3)
  • matrilin 3 (LOC100221699)
  • matrilin 3 (Matn3)
  • AV009181 Protein
  • DIPOA Protein
  • EDM5 Protein
  • HOA Protein
  • OADIP Protein
  • OS2 Protein

Bezeichner auf Proteinebene für Matrilin 3 Proteine (MATN3)

matrilin 3 , matrilin-3-like , matrilin-3

GENE ID SPEZIES
459514 Pan troglodytes
482985 Canis lupus familiaris
716677 Macaca mulatta
100071902 Equus caballus
100221699 Taeniopygia guttata
100392004 Callithrix jacchus
100470832 Ailuropoda melanoleuca
100603025 Nomascus leucogenys
4148 Homo sapiens
17182 Mus musculus
313954 Rattus norvegicus
395954 Gallus gallus
540041 Bos taurus
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