MDS1 and EVI1 Complex Locus Proteine (MECOM)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Zusätzlich bieten wir Ihnen MDS1 and EVI1 Complex Locus Antikörper (118) und MDS1 and EVI1 Complex Locus Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Ratte MECOM MECOM 294924  
Direkt bei antikoerper-online bestellen
  • +49 (0)241 95 163 153
  • +49 (0)241 95 163 155
  • Online bestellen
  • orders@antikoerper-online.de

Top MDS1 and EVI1 Complex Locus Proteine auf antikoerper-online.de

Showing 4 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   20 μg Anmelden zum Anzeigen 6 bis 8 Tage
379,93 €
Details

MECOM Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartnern

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (zeige NOTCH1 Proteine) signaling

  2. Prdm3 and prdm16 (zeige PRDM16 Proteine) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. these findings have identified a novel function for Runx1 (zeige RUNX1 Proteine) in sustaining normal mammary epithelial morphology and preventing epithelial-mesenchymal transition

  2. Leukaemogenesis by AML1 (zeige RUNX1 Proteine)-ETO (zeige RUNX1T1 Proteine) requires enhanced C/D box snoRNA/RNP (zeige RNPC3 Proteine) formation.

  3. The expression of EVI1 and SOX9 (zeige SOX9 Proteine) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (zeige FRAP1 Proteine) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (zeige FRAP1 Proteine) targeting failure

  4. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (zeige F2 Proteine)-activatable receptor PAR-1 (protease-activated receptor-1 (zeige F2R Proteine)), in Runx1 (zeige RUNX1 Proteine)/Cbfb (zeige CBFB Proteine)-deleted MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells. Similar to the effect of Runx1 (zeige RUNX1 Proteine)/Cbfb (zeige CBFB Proteine) deletion, PAR-1 (zeige MARK2 Proteine) overexpression induced CDKN1A/p21 (zeige CDKN1A Proteine) expression and attenuated proliferation in MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells

  5. EVI1 contributes to PCa (zeige FLVCR1 Proteine) progression by regulating different oncogenic functions. EVI1 regulates the PCa (zeige FLVCR1 Proteine) stem cell compartment responsible for disease initiation and also development of CRPC.

  6. oncogenic potential for EVI1 in modulating genomic stability

  7. LRG1 (zeige LRG1 Proteine) plays a crucial role in the proliferation and apoptosis of colorectal cancer (CRC (zeige CALR Proteine)) by regulating RUNX1 (zeige RUNX1 Proteine) expression.

  8. RUNX1 (zeige RUNX1 Proteine) RNA and protein are upregulated in proliferative diabetic retinopathy and in response to high glucose in vitro. Immunohistochemical staining for RUNX1 (zeige RUNX1 Proteine) showed reactivity in vessels of patient-derived fibrovascular membranes, suggesting that RUNX1 (zeige RUNX1 Proteine) upregulation is a hallmark of aberrant retinal angiogenesis.

  9. RUNX1 (zeige RUNX1 Proteine) overexpression induced partial DNA demethylation at SPI1 (zeige SPI1 Proteine) proximal promoter.

  10. mutations in the SRSF2 (zeige SRSF2 Proteine)/ASXL1 (zeige ASXL1 Proteine)/RUNX1 (zeige RUNX1 Proteine) gene panel identified as significant prognostic markers in systemic mastocytosis

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  2. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (zeige CEBPA Proteine) from EVI1-induced suppression.

  3. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (zeige CSF2 Proteine), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (zeige CSF2 Proteine) levels.

  4. Survivin (zeige BIRC5 Proteine) partially regulates HSC (zeige FUT1 Proteine) function by modulating the Evi-1 transcription factor and its downstream targets

  5. Thrombopoietin (zeige THPO Proteine)/MPL (zeige MPL Proteine) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  6. Prdm16 (zeige PRDM16 Proteine) and Prdm3 control postnatal BAT (zeige BAAT Proteine) identity and function.

  7. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  8. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (zeige MLL Proteine)) fusion protein (MFP) leukemia

  9. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (zeige CEBPB Proteine), liver inhibitory protein (LIP), induced acute myeloid leukemia (zeige BCL11A Proteine) with short latencies in a mouse bone marow transplantation model.

  10. Transient Evi1 transfection inhibited TGF-beta (zeige TGFB1 Proteine)-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta (zeige TGFB1 Proteine) in MC-26 (zeige Glycam1 Proteine) mouse colon cancer cells.

MDS1 and EVI1 Complex Locus (MECOM) Protein Überblick

Protein Überblick

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit MECOM

  • MDS1 and EVI1 complex locus (mecom)
  • MDS1 and EVI1 complex locus (MECOM)
  • MDS1 and EVI1 complex locus (LOC100343228)
  • MDS1 and EVI1 complex locus (Mecom)
  • runt-related transcription factor 1 (RUNX1)
  • AML1 Protein
  • AML1-EVI-1 Protein
  • AMLCR1 Protein
  • CBFA2 Protein
  • D630039M04Rik Protein
  • EVI-1 Protein
  • Evi1 Protein
  • im:7140716 Protein
  • Jbo Protein
  • Mds Protein
  • Mds1 Protein
  • Mds1-Evi1 Protein
  • PEBP2aB Protein
  • Prdm3 Protein
  • Znfpr1b1 Protein

Bezeichner auf Proteinebene für MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPEZIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
Ausgewählte Anbieter für MDS1 and EVI1 Complex Locus Proteine (MECOM)
Haben Sie etwas anderes gesucht?