anti-Leucine Carboxyl Methyltransferase 1 (LCMT1) Antikörper

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999. Zusätzlich bieten wir Ihnen Leucine Carboxyl Methyltransferase 1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
LCMT1 51451 Q9UIC8
LCMT1 30949  
LCMT1 361643 Q6P4Z6
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Top anti-Leucine Carboxyl Methyltransferase 1 Antikörper auf antikoerper-online.de

Showing 10 out of 63 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert FACS, WB HEK293T cells transfected with either RC200018 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-LCMT1 antibody (ABIN2454710), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LCMT1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LCMT1. 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
366,67 €
Details
Human Maus Unkonjugiert FACS, IF, WB HEK293T cells transfected with either RC200018 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-LCMT1 antibody (ABIN2454742), and then analyzed by flow cytometry. Anti-LCMT1 mouse monoclonal antibody (ABIN2454742) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LCMT1 (RC200018). 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
366,67 €
Details
Human Maus Unkonjugiert FACS, IF, IHC, WB Anti-LCMT1 mouse monoclonal antibody (ABIN2454745) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LCMT1 (RC200018). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LCMT1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LCMT1. 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
366,67 €
Details
Human Maus Unkonjugiert IHC, WB Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-LCMT1 mouse monoclonal antibody. (ABIN2454743) HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LCMT1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LCMT1. 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
418,10 €
Details
Human Maus Unkonjugiert FACS, IF, IHC (p), WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
583,17 €
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Human Maus Unkonjugiert FACS, WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
583,17 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Mouse cerebellum lysates probed with LCMT1 Polyclonal Antibody, unconjugated  at 1:300 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 90 minutes at 37°C. 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
304,36 €
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Human Maus Unkonjugiert IHC (p), WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
626,83 €
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Human Kaninchen Alexa Fluor 594 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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Human Kaninchen Cy3 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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LCMT1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen Leucine Carboxyl Methyltransferase 1 Interaktionspartner

Human Leucine Carboxyl Methyltransferase 1 (LCMT1) Interaktionspartner

  1. LCMT1-PME-1 (zeige PPME1 Antikörper) methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division

  2. alterations in the membrane localization of PP2A (zeige PPP2R4 Antikörper) and Tau following down-regulation of LCMT1 may lead to PP2A (zeige PPP2R4 Antikörper) and Tau dysfunction in AD.

  3. Data indicate that PP2A (zeige PPP2R4 Antikörper) holoenzyme biogenesis and activity are controlled by five PP2A (zeige PPP2R4 Antikörper) modulators, consisting of alpha4, PTPA (zeige PPP2R4 Antikörper), LCMT1, PME-1 (zeige PPME1 Antikörper) and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.

  4. GSK-3beta (zeige GSK3b Antikörper) can inhibit PP2A (zeige PPP2R4 Antikörper) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 (zeige PPME1 Antikörper) and inhibition of PPMT1

  5. determined crystal structures of human LCMT-1 in isolation and in complex with PP2A (zeige PPP2R4 Antikörper) stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A (zeige PPP2R4 Antikörper)

  6. X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet (zeige MAT1A Antikörper)) has been solved to a resolution of 2 A.

  7. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Mouse (Murine) Leucine Carboxyl Methyltransferase 1 (LCMT1) Interaktionspartner

  1. LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3 (zeige HDAC3 Antikörper), a reported target of the methylation-dependent PP4R1 (zeige PPP4R1 Antikörper)-PP4c (zeige PPP4C Antikörper) complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A (zeige PPP2R2B Antikörper)-related phosphatases and, consequently, their holoenzyme assembly and function.

  2. In LCMT1 deficiency enzyme activity and methylation of PP2A (zeige PPP2R2B Antikörper) are reduced in a coordinate fashion, suggesting that LCMT1 is the only PP2A (zeige PPP2R2B Antikörper) methyltransferase.

  3. Enhanced expression of LCMT1 in cultured neuroblastoma cells, which increases endogenous methylated catalytic C subunit and Balpha levels, induces changes in F-actin organization.

  4. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Leucine Carboxyl Methyltransferase 1 (LCMT1) Antigen-Profil

Protein Überblick

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA\; MIM 176915) (De Baere et al., 1999

Genbezeichner und Symbole assoziert mit LCMT1

  • leucine carboxyl methyltransferase 1 (LCMT1) Antikörper
  • leucine carboxyl methyltransferase 1 (lcmt1) Antikörper
  • leucine carboxyl methyltransferase 1 (ANI_1_2090074) Antikörper
  • leucine carboxyl methyltransferase 1 (PTRG_02142) Antikörper
  • leucine carboxyl methyltransferase 1 (MCYG_00360) Antikörper
  • leucine carboxyl methyltransferase 1 (AOR_1_842194) Antikörper
  • leucine carboxyl methyltransferase 1 (Tsp_08223) Antikörper
  • leucine carboxyl methyltransferase 1 (Lcmt1) Antikörper
  • AL033290 Antikörper
  • Lcmt Antikörper
  • LCMT-1 Antikörper
  • MGC114784 Antikörper
  • PPMT1 Antikörper
  • zgc:101094 Antikörper

Bezeichner auf Proteinebene für LCMT1

leucine carboxyl methyltransferase 1 , [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1 , protein phosphatase methyltransferase 1 , protein-leucine O-methyltransferase

GENE ID SPEZIES
416565 Gallus gallus
447907 Danio rerio
467930 Pan troglodytes
548787 Xenopus (Silurana) tropicalis
608360 Canis lupus familiaris
734508 Xenopus laevis
4983025 Aspergillus niger CBS 513.88
6338383 Pyrenophora tritici-repentis Pt-1C-BFP
9225317 Arthroderma otae CBS 113480
10099666 Aspergillus oryzae RIB40
10906787 Trichinella spiralis
100196453 Salmo salar
100528205 Ictalurus punctatus
100606762 Nomascus leucogenys
51451 Homo sapiens
30949 Mus musculus
361643 Rattus norvegicus
618021 Bos taurus
Ausgewählte Anbieter für anti-Leucine Carboxyl Methyltransferase 1 (LCMT1) Antikörper
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