anti-Kelch-Like 3 (Drosophila) (KLHL3) Antikörper

KLHL3 is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. Zusätzlich bieten wir Ihnen KLHL3 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
KLHL3 100503085  
KLHL3 26249 Q9UH77
KLHL3 498697  
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Top anti-KLHL3 Antikörper auf antikoerper-online.de

Showing 10 out of 67 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-KLHL3 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
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Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-KLHL3 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>HepG2 cell lysate WB Suggested Anti-KLHL3 <br /> Antibody Titration: 1.25 µg/mL ELISA Titer: 1:62500 <br /> Positive Control: HepG2 cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
288,68 €
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Rind (Kuh) Kaninchen Unkonjugiert IHC, WB Sample Type : Human brain stem cells Primary Antibody Dilution : 1:500 Secondary Antibody : Goat anti-rabbit Alexa-Fluor 594 Secondary Antibody Dilution : 1:1000 Color/Signal Descriptions : KLHL3: Red DAPI:Blue Gene Name : KLHL3 Submitted by : Dr. Yuzhi Chen, University of Arkansas for Medical Science WB Suggested Anti-KLHL3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: THP-1 cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KLHL3 Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of A549 cells, using KLHL3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
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Fledermaus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
583,17 €
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Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Human Kaninchen Unkonjugiert WB KLHL3 Antibody (Center)  western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the KLHL3 antibody detected the KLHL3 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
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Fledermaus Kaninchen Unkonjugiert IHC (p), WB Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
801,43 €
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Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded rat kidney, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with KLHL3 Polyclonal Antibody, Unconjugated  at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
304,36 €
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KLHL3 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen KLHL3 Interaktionspartner

Mouse (Murine) Kelch-Like 3 (Drosophila) (KLHL3) Interaktionspartner

  1. However, phosphorylation of SPAK (zeige STK39 Antikörper) and NCC (zeige SLC12A3 Antikörper) at distal convoluted tubules were almost completely absent even in WNK4 (zeige WNK4 Antikörper)(-/-)KLHL3(R528H/R528H) mice. In conclusion, increased WNK1 (zeige WNK1 Antikörper) was unable to compensate for WNK4 (zeige WNK4 Antikörper) deficiency and phosphorylate the NCC (zeige SLC12A3 Antikörper), indicating that WNK4 (zeige WNK4 Antikörper) is indispensable for the onset of PHAII.

  2. the heterozygous deletion of KLHL3 was not sufficient to cause PHAII, indicating that autosomal dominant type pseudohypoaldosteronism type II (PHAII) is caused by the dominant negative effect of mutant KLHL3.

  3. Potassium depletion stimulates NCC (zeige SLC12A3 Antikörper) via phosphorylation and inactivation of the KLHL3 and promoting increased blood pressure.

  4. KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8 (zeige CLDN8 Antikörper)

  5. increased protein expression levels of WNK1 (zeige WNK1 Antikörper) and WNK4 (zeige WNK4 Antikörper) kinases cause PHAII by KLHL3 R528H mutation due to impaired KLHL3-Cullin3-mediated ubiquitination.

Human Kelch-Like 3 (Drosophila) (KLHL3) Interaktionspartner

  1. Mutation in the KLHL3 gene is associated with Gordon syndrome.

  2. The results demonstrate that Hcy decreases the expression of cMyBP-C through a KLHL3-mediated ubiquitin-proteasome pathway, and thereby influences heart development.

  3. This study provides substantial new insights into the role of phosphorylation of KLHL3 in regulating the interaction with WNK4 (zeige WNK4 Antikörper)

  4. Data indicate that WNK lysine deficient protein kinase 4 protein (WNK4) was degraded not only by proteasomes but also by atypical protein kinase C scaffold protein p62 (p62)-kelch-like 3 protein (KLHL3)-mediated selective autophagy.

  5. Familial hyperkalemia and hypertension caused by KLHL3 mutations is accompanied by hypercalciuria as well as hyperkalemia and hypertension.

  6. Akt (zeige AKT1 Antikörper) and PKA phosphorylated KLHL3 at S433, and phosphorylation of KLHL3 by PKA inhibited WNK4 (zeige WNK4 Antikörper) degradation.

  7. KLHL3 is phosphorylated at serine 433 in the Kelch domain (a site frequently mutated in hypertension with hyperkalemia) by protein kinase C (zeige PKC Antikörper) in cultured cells and that this phosphorylation prevents WNK4 (zeige WNK4 Antikörper) binding and degradation.

  8. Hyperkalemic hypertension-associated cul3 (zeige CUL3 Antikörper) mutations depletes KLHL3, preventing WNK degradation, despite increased CUL3 (zeige CUL3 Antikörper)-mediated WNK ubiquitylation.

  9. CUL3 (zeige CUL3 Antikörper) and KLHL3 gene products are physiologically important regulators of thiazide-sensitive distal nephron sodium chloride reabsorption.

  10. analysis of how mutations of KLHL3 show less ability to ubiquitinate WNK4 (zeige WNK4 Antikörper) because of KLHL3's low stability and/or decreased binding to CUL3 (zeige CUL3 Antikörper) or WNK4 (zeige WNK4 Antikörper)

KLHL3 Antigen-Profil

Protein Überblick

This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D)\; a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Genbezeichner und Symbole assoziert mit KLHL3

  • kelch-like 3 (Drosophila) (KLHL3) Antikörper
  • kelch-like 3 (Klhl3) Antikörper
  • kelch-like family member 3 (KLHL3) Antikörper
  • kelch-like family member 3 (Klhl3) Antikörper
  • 7530408C15Rik Antikörper
  • AI430941 Antikörper
  • EG627648 Antikörper
  • PHA2D Antikörper
  • RGD1565218 Antikörper

Bezeichner auf Proteinebene für KLHL3

kelch-like protein 3 , kelch-like 3

GENE ID SPEZIES
100174246 Pongo abelii
100503085 Mus musculus
416303 Gallus gallus
481523 Canis lupus familiaris
100519539 Sus scrofa
26249 Homo sapiens
533364 Bos taurus
498697 Rattus norvegicus
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