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Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Zusätzlich bieten wir Ihnen Junctophilin 1 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal JPH1 Primary Antibody für ICC, IF - ABIN4327979
Boncompagni, Thomas, Lopez, Allen, Yuan, Kranias, Franzini-Armstrong, Perez: Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. in PLoS ONE 2012
Human Polyclonal JPH1 Primary Antibody für ELISA, WB - ABIN527954
Vihola, Sirito, Bachinski, Raheem, Screen, Suominen, Krahe, Udd: Altered expression and splicing of Ca(2+) metabolism genes in myotonic dystrophies DM1 and DM2. in Neuropathology and applied neurobiology 2013
Results show that JPH1 and GDAP1 (zeige GDAP1 Antikörper) share a common pathway and depend on each other; therefore, JPH1 can contribute to the phenotypical consequences of GDAP1 (zeige GDAP1 Antikörper) mutations.
This study suggests that genetic variants of JPH1 may modulate the effect of smoking on carotid plaque burden.
This study demonstrates that both JP1 and JP2 (zeige JPH2 Antikörper) in skeletal muscle undergo Ca2 (zeige CA2 Antikörper)+-dependent proteolysis by endogenous proteases when the intracellular Ca2 (zeige CA2 Antikörper)+ is raised within the physiological range for a sustained period
JP1 and JP2 (zeige JPH2 Antikörper) can facilitate the assembly of DHPR (zeige QDPR Antikörper) with other proteins of the excitation-contraction coupling machinery
JP1 gene is expressed during the whole process of cardiogenesis, while JP1 protein only appears during the early stage.
an important fraction of resting plasmalemmal Ca(2 (zeige CA2 Antikörper)+) permeability is mediated by the Orai1 (zeige TMEM132A Antikörper) pathway, which contributes to the control of [Ca(2 (zeige CA2 Antikörper)+)](rest) and resting Ca(2 (zeige CA2 Antikörper)+) stores and that this pathway is defective in JP1 KO myotubes
Skeletal muscle JP1/2 damage is significantly associated with early (0-3 days) strength deficits after performance of eccentric contractions.
Abnormal junctional membrane structures in cardiac myocytes in transgenic mice expressing junctophilin type 1.
We report a novel Junctophilin subtype, JP-4 (zeige JPH4 Antikörper), encoded in the human (chromosome 14q11.1) and mouse (chromosome 14C1-2) genomes. JP-4 (zeige JPH4 Antikörper) shares characteristic structural features with other JP subtypes, and is found in the brain.
Junctophilins support the Ca(2 (zeige CA2 Antikörper)+)-mediated communication between voltage-gated Ca(2 (zeige CA2 Antikörper)+) channels, which modulates the excitability of Purkinje cells and is fundamental to cerebellar long-term depression and motor functions.
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family.
, junctophilin 1a
, junctophilin type 1
, junctophilin type1