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Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial Proteine (IDH2)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Zusätzlich bieten wir Ihnen IDH2 Antikörper (98) und IDH2 Kits (13) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Showing 10 out of 20 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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Hefe Arabidopsis thaliana His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.788,41 €
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.997,93 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.997,93 €
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Hefe Macaca fascicularis His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.997,93 €
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HOST_Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
438,90 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
640,00 €
Details

IDH2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartnern

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (zeige IDH3B Proteine)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (zeige IDH3B Proteine)

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (zeige GRX1 Proteine) activity.

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. Functional studies demonstrated that IDH2 and PIK3CA (zeige PIK3CA Proteine) hotspot mutations are likely drivers of solid papillary carcinoma with reverse polarity

  2. IDH1 (zeige IDH1 Proteine) and IDH2 mutants inhibit TET-promoted oxidation of RNA 5-methylcytosine to 5hydroxymethylcytosine.

  3. IDH2 mutation is associated with polycythemia vera (zeige IGF2BP3 Proteine) and essential thrombocythemia.

  4. Mutations in some enzymes of the TCA cycle: Isocitrate dehydrogenase (IDH (zeige IDH1 Proteine)), succinate dehydrogenase (SDH (zeige SDHA Proteine)) and fumarate hydratase (FH (zeige FH Proteine)) are associated with the accumulation of metabolites that are able to influence many aspects of cancer development and progression and for this reason are termed onco-metabolites.

  5. A total of 152 deficient DNA mismatch repair system (dMMR) of colorectal cancers (CRCs) patients were analyzed. No IDH (zeige IDH1 Proteine) mutation was observed in dMMR CRC (zeige CALR Proteine), nor in IDH1 (zeige IDH1 Proteine) or IDH2. Especially, no mutation was found in sporadic dMMR CRC (zeige CALR Proteine) which is known to be associated with CpG island methylator phenotype.

  6. the contribution of IDH1 (zeige IDH1 Proteine) and IDH2 mutations to gliomagenesis[review]

  7. Only three IDH2(R172) mutation cases were detected in this series of patients with astrocytomas and oligodendrogliomas

  8. review examines mutant IDH1/2 and TET2 enzymes in the context of responses to DNA damage and their potential involvement in age-related genomic instability.

  9. The study confirmed the importance of the IDH1 (zeige IDH1 Proteine)/2 mutation and hypermethylation of the MGMT (zeige MGMT Proteine) gene promoter being present in brain Glioma tissue.

  10. these data suggest that IDH2 may be a tumor suppressor in that its loss may promote malignant progression of gastric cancer via NF-kappaB (zeige NFKB1 Proteine)-dependent increases in MMP7 (zeige MMP7 Proteine) activity.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. The enzyme is highly sensitive to Mg(2 (zeige MCOLN1 Proteine)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (zeige MCOLN1 Proteine)+)] in mitochondrial energy metabolism.

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.

  2. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  3. IDH2 and NPM1 (zeige GJA1 Proteine) mutations synergize in the development and maintenance of acute myeloid leukemia (zeige BCL11A Proteine) stem-like cells.

  4. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

  5. These data demonstrate the proto-oncogenic role of mutant IDH2.

  6. The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.

  7. Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (zeige HIF1A Proteine) expression, blunted mRNA expression of HIF-1alpha (zeige HIF1A Proteine), VEGF (zeige VEGFA Proteine), and the glucose transport protein Glut-1 (zeige SLC1A3 Proteine) was also observed.

  8. IDH2 mutants can cooperate with oncogenic Flt3 (zeige FLT3 Proteine) or Nras (zeige NRAS Proteine) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage

  9. SIRT3 (zeige SIRT3 Proteine) protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status

  10. Results suggest that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (zeige IDH1 Proteine) plays a role in apoptosis induced by high glucose and may contribute to various pathologies associated with the long-term complications of diabetes.

IDH2 Protein Überblick

Protein Überblick

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Genbezeichner und Symbole assoziert mit IDH2

  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2)
  • Isocitrate dehydrogenase [NAD] regulatory subunit 2 (IDH2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2)
  • D2HGA2 Protein
  • E430004F23 Protein
  • F6P23.14 Protein
  • F6P23_14 Protein
  • ICD-M Protein
  • IDH Protein
  • Idh-2 Protein
  • IDH-II Protein
  • IDH2 Protein
  • IDHM Protein
  • IDP Protein
  • IDPm Protein
  • isocitrate dehydrogenase II Protein
  • isocitrate dehydrogenase subunit 2 Protein
  • mNADP-IDH Protein
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 Protein
  • wu:fb33c06 Protein
  • wu:fk31e05 Protein
  • wu:fq43b01 Protein
  • zgc:55485 Protein

Bezeichner auf Proteinebene für IDH2

isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like , NADP(+)-specific ICDH , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase

GENE ID SPEZIES
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
701480 Macaca mulatta
100155880 Sus scrofa
100441867 Pongo abelii
816218 Arabidopsis thaliana
3418 Homo sapiens
386951 Danio rerio
380013 Xenopus laevis
431056 Gallus gallus
327669 Bos taurus
269951 Mus musculus
361596 Rattus norvegicus
479043 Canis lupus familiaris
397603 Sus scrofa
Ausgewählte Anbieter für IDH2 Proteine (IDH2)
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