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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Zusätzlich bieten wir Ihnen IDH2 Antikörper (115) und IDH2 Kits (14) und viele weitere Produktgruppen zu diesem Protein an.
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Leaf IDH activity reduced by 43% in mutant
IDH1/2 mutations induce a homologous recombination defect that renders tumor cells exquisitely sensitive to poly(adenosine 5'-diphosphate-ribose) polymerase inhibitors
To confirm this result, we analyzed survival data from 142 LGGs from TCGA with IDH1 (zeige IDH1 Proteine)/IDH2 mutations and no 1p19q codeletion. Despite the high rate of censured data, we found that CNLOH 17p, including the TP53 (zeige TP53 Proteine) locus, was associated with better outcome (OR = 0.27; p = .026)
6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1 (zeige IDH1 Proteine)/IDH2, ATRX (zeige ATRX Proteine), and 1p/19q results.
In this review, we focus on three key areas in acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) developmental therapeutics: FLT3 (zeige FLT3 Proteine) inhibitors, IDH(IDH1 (zeige IDH1 Proteine) and IDH2 ) inhibitors, and drugs that may be particularly beneficial in secondary AML (zeige RUNX1 Proteine)
The role of mutant IDH1 (zeige IDH1 Proteine) and IDH2 inhibitors in the treatment of acute myeloid leukemia (zeige BCL11A Proteine).
olaparib and other PARP inhibitors killed cells in multiple cancer cell lines that harbor IDH1 (zeige IDH1 Proteine) and IDH2 mutations. In addition, glioma cell lines generated from patient tumors with IDH1 (zeige IDH1 Proteine) mutations were vulnerable to the investigational PARP inhibitor talazoparib . In mice, olaparib slowed the growth of implanted IDH1 (zeige IDH1 Proteine)-mutant tumors.
demonstrate the presence of the IDH2 p.R172K/S mutation in patients with cutaneous localizations of angioimmunoblastic T-cell lymphomas.
an IDH mutant-enriched subtype of cholangiocarcinoma with distinct molecular features including low expression of chromatin modifiers, elevated expression of mitochondrial genes, and increased mitochondrial DNA copy number, is reported.
IDH (zeige IDH1 Proteine) mutations define a distinct subtype of ICC, a malignancy that is largely refractory to current therapies. Our work demonstrates that IDHm ICC cells are hypersensitive to dasatinib and critically dependent on SRC (zeige SRC Proteine) activity for survival and proliferation, pointing to new therapeutic strategies against these cancers.
Mutations in the IDH1 (zeige IDH1 Proteine) and IDH2 genes perturb the epigenome through cytosine methylation, histone post-translational modifications and transcription factors. [review]
Increased obesity resistance and insulin (zeige INS Proteine) sensitivity in mice lacking the IDH2 gene has been documented.
treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD (zeige SOD2 Proteine) expression, eNOS (zeige NOS3 Proteine) phosphorylation and NO production in endothelial cells
Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.
IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.
IDH2 and NPM1 (zeige GJA1 Proteine) mutations synergize in the development and maintenance of acute myeloid leukemia (zeige BCL11A Proteine) stem-like cells.
7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.
These data demonstrate the proto-oncogenic role of mutant IDH2.
The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.
Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (zeige HIF1A Proteine) expression, blunted mRNA expression of HIF-1alpha (zeige HIF1A Proteine), VEGF (zeige VEGFA Proteine), and the glucose transport protein Glut-1 (zeige SLC1A3 Proteine) was also observed.
IDH2 mutants can cooperate with oncogenic Flt3 (zeige FLT3 Proteine) or Nras (zeige NRAS Proteine) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage
The enzyme is highly sensitive to Mg(2 (zeige MCOLN1 Proteine)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (zeige MCOLN1 Proteine)+)] in mitochondrial energy metabolism.
Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (zeige IDH3B Proteine)
analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (zeige IDH3B Proteine)
These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (zeige GRX1 Proteine) activity.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
, isocitrate dehydrogenase [NADP], mitochondrial
, oxalosuccinate decarboxylase
, NADP+-specific isocitrate dehydrogenase
, NADPH-specific isocitrate dehydrogenase
, isocitrate dehydrogenase 2 (NADP+), mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial-like