anti-Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Antikörper

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Zusätzlich bieten wir Ihnen IDH1 Kits (24) und IDH1 Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
IDH1 3417 O75874
IDH1 15926 O88844
IDH1 24479 P41562
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Top anti-IDH1 Antikörper auf antikoerper-online.de

Showing 10 out of 210 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>Sample type:</b> 1. HEPG2 (50ug)<br>2. Drosophila extract (50ug)<br><b>Primary dilution:</b> 1:1000<br><b>Secondary Antibody:</b> mouse anti-Rabbit HRP<br><b>Secondary Dilution:</b> 1:5000<br><b>Image Submitted by:</b> Xinyang Bing<br>Laurentian University 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert FACS, IF, IHC (p), WB Western blot analysis of IDH1 Antibody (N-term) (ABIN391659) in mouse liver tissue and 293 cell line lysates (35 µg/lane). IDH1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain reacted with IDH1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert FACS, IF, IHC (p), WB Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with IDH1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of IDH1 Antibody (Center) (ABIN391660) in HepG2 cell line and mouse liver tissue lysates (35 µg/lane). IDH1 (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert IF, IHC, WB Immunohistochemical staining of paraffin-embedded breast tissue using anti-IDH1 mouse monoclonal antibody. (ABIN2452633, Dilution 1:50) Immunohistochemical staining of paraffin-embedded colon tissue using anti-IDH1 mouse monoclonal antibody. (ABIN2452633, Dilution 1:50) 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$423.50
Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: Isocitrate Dehydrogenase 1/IDH1 Antibody [NBP1-52118] - Analysis of Isocitrate dehydrogenase (aa153-164) in HepG2 lysate (35ug protein in RIPA buffer) using NBP1-52118 at 0.3 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry: Isocitrate Dehydrogenase 1/IDH1 Antibody [NBP1-87428] - Immunohistochemical staining of human prostate shows strong cytoplasmic and nuclear positivity in glandular cells. Western Blot: Isocitrate Dehydrogenase 1/IDH1 Antibody [NBP1-87428] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert IP, WB Western Blot: Isocitrate dehydrogenase Antibody [NBP2-32150] - Samples: Whole cell lysate (50 ug) from K562, HeLa, 293T, mouse TCMK-1, mouse NIH3T3, and rat C6 cells. Antibodies: Affinity purified rabbit anti-Isocitrate dehydrogenase antibody NBP2-32150 used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. Immunoprecipitation: Isocitrate dehydrogenase Antibody [NBP2-32150] - Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-Isocitrate dehydrogenase antibody NBP2-32150 used for IP at 6 ug/mg lysate. For blotting immunoprecipitated Isocitrate dehydrogenase, NBP2-32150 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: Isocitrate Dehydrogenase 1/IDH1 Antibody [NBP1-52119] - Analysis of Isocitrate dehydrogenase (aa65-77) in HepG2 lysate (35ug protein in RIPA buffer) using NBP1-52119 at 0.1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details

IDH1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-IDH1 Antikörper

  1. Human Monoclonal IDH1 Primary Antibody für IF, IHC - ABIN2452633 : Elhammali, Ippolito, Collins, Crowley, Marasa, Piwnica-Worms: A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor. in Cancer discovery 2014 (PubMed)

  2. Human Polyclonal IDH1 Primary Antibody für ELISA, WB - ABIN4327715 : Abbas, Lugthart, Kavelaars, Schelen, Koenders, Zeilemaker, van Putten, Rijneveld, Löwenberg, Valk: Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. in Blood 2010 (PubMed)

  3. Human Polyclonal IDH1 Primary Antibody für IP, WB - ABIN4327718 : Abdel Malik, Zippel, Frömel, Heidler, Zukunft, Walzog, Ansari, Pampaloni, Wingert, Rieger, Wittig, Fisslthaler, Fleming: AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis. in Circulation research 2016 (PubMed)

  4. Human Polyclonal IDH1 Primary Antibody für IHC, IHC (p) - ABIN4327716 : ODwyer, Ralton, OShea, Murray: The proteomics of colorectal cancer: identification of a protein signature associated with prognosis. in PLoS ONE 2011 (PubMed)

  5. Cow (Bovine) Polyclonal IDH1 Primary Antibody für IHC, WB - ABIN2785883 : Kullberg, Nilsson, Arnason, Harley, Janke: Housekeeping genes for phylogenetic analysis of eutherian relationships. in Molecular biology and evolution 2006 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen IDH1 Interaktionspartner

Human Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. IDH1/2 mutations induce a homologous recombination defect that renders tumor cells exquisitely sensitive to poly(adenosine 5'-diphosphate-ribose) polymerase inhibitors

  2. To confirm this result, we analyzed survival data from 142 LGGs from TCGA with IDH1/IDH2 (zeige IDH2 Antikörper) mutations and no 1p19q codeletion. Despite the high rate of censured data, we found that CNLOH 17p, including the TP53 (zeige TP53 Antikörper) locus, was associated with better outcome (OR = 0.27; p = .026)

  3. Results suggest that to better treat gliomas, isocitrate dehydrogenase (NADP(+)) 1 (IDH-1) mutation status should be included when determining WHO2007 grade in glioma patients.

  4. The found of this study suggest that IDH1 mutation status had greater impact than histological and other genomic features on miRNA expression patterns.

  5. 6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1/IDH2 (zeige IDH2 Antikörper), ATRX (zeige ATRX Antikörper), and 1p/19q results.

  6. Study indicates IDH1 mutation status was not predictive of 6-month progression free survival or radiographic response in recurrent glioblastoma trials for this data set.

  7. Study demonstrates that patients with IDH1 mutant tumor have significantly higher brain network global efficiency and degree compared to patients with wild type tumor, despite having larger tumor volumes.

  8. In this review, we focus on three key areas in acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper)) developmental therapeutics: FLT3 (zeige FLT3 Antikörper) inhibitors, IDH(IDH1 and IDH2 (zeige IDH2 Antikörper) ) inhibitors, and drugs that may be particularly beneficial in secondary AML (zeige RUNX1 Antikörper)

  9. The role of mutant IDH1 and IDH2 (zeige IDH2 Antikörper) inhibitors in the treatment of acute myeloid leukemia (zeige BCL11A Antikörper).

  10. Data suggest that identification of IDH1-R132H and ATRX (zeige ATRX Antikörper) loss status in the primary-recurrent gliomas may aid in treatment strategy selection, therapeutic trial design, and clinical prognosis evaluation.

Mouse (Murine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system.

  2. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis

  3. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM (zeige ATM Antikörper) by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC (zeige FUT1 Antikörper) self-renewal, independent of TET2 (zeige TET2 Antikörper).

  4. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1 (zeige ACO1 Antikörper), enzymes involved in the TCA cycle, were elevated.

  5. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells

  6. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

  7. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H.

  8. MiR (zeige MLXIP Antikörper)-181a regulates lipid metabolism via IDH1

  9. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity.

  10. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas.

Cow (Bovine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. Data suggest that the expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors.

Pig (Porcine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (zeige IDH3B Antikörper)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (zeige IDH3B Antikörper)

  3. These results suggest that IDPm (zeige IDH2 Antikörper) plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (zeige GRX1 Antikörper) activity.

IDH1 Antigen-Profil

Protein Überblick

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Genbezeichner und Symbole assoziert mit IDH1

  • isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1) Antikörper
  • isocitrate dehydrogenase 1 (NADP+), soluble (Idh1) Antikörper
  • isocitrate dehydrogenase 1 (NADP+) L homeolog (idh1.L) Antikörper
  • isocitrate dehydrogenase (NADP(+)) 1, cytosolic (Idh1) Antikörper
  • isocitrate dehydrogenase 1 (NADP+), soluble (idh1) Antikörper
  • parathyroid hormone 2 receptor (PTH2R) Antikörper
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) Antikörper
  • AI314845 Antikörper
  • AI788952 Antikörper
  • cb876 Antikörper
  • E030024J03Rik Antikörper
  • fm90e09 Antikörper
  • Id-1 Antikörper
  • IDCD Antikörper
  • IDH Antikörper
  • Idh-1 Antikörper
  • IDP Antikörper
  • Idpc Antikörper
  • im:7143416 Antikörper
  • NADP-CICDH Antikörper
  • PICD Antikörper
  • wu:fm90e09 Antikörper

Bezeichner auf Proteinebene für IDH1

isocitrate dehydrogenase 1 (NADP+), soluble , isocitrate dehydrogenase [NADP] cytoplasmic-like , NADP(+)-specific ICDH , NADP-dependent isocitrate dehydrogenase, cytosolic , NADP-dependent isocitrate dehydrogenase, peroxisomal , isocitrate dehydrogenase [NADP] cytoplasmic , oxalosuccinate decarboxylase , IDH , IDP , cytosolic NADP-isocitrate dehydrogenase , isocitrate dehydrogenase 1 , Isocitrate dehydrogenase 1, soluble , ICD-M , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase [NADP], mitochondrial

GENE ID SPEZIES
478889 Canis lupus familiaris
751618 Felis catus
100414768 Callithrix jacchus
3417 Homo sapiens
15926 Mus musculus
494713 Xenopus laevis
100328559 Oryctolagus cuniculus
24479 Rattus norvegicus
281235 Bos taurus
100006589 Danio rerio
100170146 Sus scrofa
443257 Ovis aries
397603 Sus scrofa
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