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IGF2R encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. Zusätzlich bieten wir Ihnen IGF2R Kits (25) und IGF2R Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 144 products:
Cow (Bovine) Monoclonal IGF2R Primary Antibody für CyTOF, ELISA - ABIN152673
Dintzis, Velculescu, Pfeffer: Receptor extracellular domains may contain trafficking information. Studies of the 300-kDa mannose 6-phosphate receptor. in The Journal of biological chemistry 1994
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Human Monoclonal IGF2R Primary Antibody für CyTOF, FACS - ABIN269096
El-Shewy, Lee, Obeid, Jaffa, Luttrell: The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. in The Journal of biological chemistry 2007
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Human Monoclonal IGF2R Primary Antibody für FACS, WB - ABIN192250
Leksa, Godár, Cebecauer, Hilgert, Breuss, Weidle, Horejsí, Binder, Stockinger: The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration. in The Journal of biological chemistry 2002
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Human Monoclonal IGF2R Primary Antibody für FACS, WB - ABIN609650
Gasanov, Koina, Beagley, Aitken, Hansbro: Identification of the insulin-like growth factor II receptor as a novel receptor for binding and invasion by Listeria monocytogenes. in Infection and immunity 2005
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Human Polyclonal IGF2R Primary Antibody für IF (p), IHC (p) - ABIN719711
Geng, Yang, Li, Song, Liu, Qiu, Liu, Yang: Insulin-like growth factor-2 enhances functions of antigen (Ag)-specific regulatory B cells. in The Journal of biological chemistry 2014
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Human Monoclonal IGF2R Primary Antibody für FACS, WB - ABIN94039
Schatzlmaier, Supper, Göschl, Zwirzitz, Eckerstorfer, Ellmeier, Huppa, Stockinger: Rapid multiplex analysis of lipid raft components with single-cell resolution. in Science signaling 2015
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Human Polyclonal IGF2R Primary Antibody für ELISA - ABIN561444
Harris, Crocker, Baker, Aplin, Westwood: IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptor. in Biology of reproduction 2011
Human Monoclonal IGF2R Primary Antibody für FACS - ABIN2479310
Rezgui, Williams, Savage, Prince, Zaccheo, Jones, Crump, Hassan: Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth. in Journal of molecular endocrinology 2009
Heterodimers of the SNX (zeige ANXA7 Antikörper)-BAR proteins, SNX1 (zeige SNX1 Antikörper), SNX2 (zeige SNX2 Antikörper), SNX5 (zeige SNX5 Antikörper), and SNX6 (zeige SNX6 Antikörper), are the cargo-selective elements that mediate the retrograde transport of CI-MPR from endosomes to the trans-Golgi networ independently of the core retromer trimer.
Sequence-dependent cargo recognition by SNX (zeige ANXA7 Antikörper)-BARs mediates retromer-independent transport of CI-MPR.
These data suggest the involvement of IGF-2, IGF-1R (zeige IGF1R Antikörper), IGF-2R and PTEN (zeige PTEN Antikörper) in temporo-spatial patterning of basic cellular processes (proliferation, differentiation) during normal tooth development.
Findings indicate that IGF2R expression is controlled posttranscriptionally by two factors that associate with Igf2r mRNA and suggest that miR (zeige MLXIP Antikörper)-195 and CUGBP1 (zeige CELF1 Antikörper) dampen IGF signaling by inhibiting IGF2R translation.
Previously characterized disease-causing mutations in IGF2, IGF1R (zeige IGF1R Antikörper), IGF2R, or IGFALS (zeige IGFALS Antikörper) all were found in the general population but with allele frequencies of <1:30,000.
IGF2R plays a minor role in regulating the activity of IGF1R (zeige IGF1R Antikörper) under a variety of conditions and that due to their high expression levels, IGFBPs are the dominant mechanism to regulating IGF network activation
Data show one single nucleotide polymorphism (SNP) in Fox transcription factor FOXO3 (FOXO3 (zeige FOXO3 Antikörper)) was significantly associated with longevity, and the six SNPs in proto-oncogene (zeige RAB1A Antikörper) protein AKT1 (AKT1 (zeige AKT1 Antikörper)) gene and in IGF-2 Receptor (IGF-2R) gene are not.
CREB (zeige CREB1 Antikörper) plays an important role in the inhibition of IGF2R expression by binding to the IGF2R promoter and further suppresses H9c2 cardiomyoblast cell apoptosis induced by IGF2R signaling under hypoxic conditions.
This study showed that Plasma IGF2R levels were positively correlated with plasma HIV viral load.
IGF2R gene polymorphism and circulating IGF2R are associated with T2DM
Selective M6PR (zeige M6PR Antikörper) down-regulation has a critical role in CD8 (zeige CD8A Antikörper)(+) T cell survival.
Expression of imprinted gene Igf2r was unregulated in haploid androgenetic/gynogenetic blastocysts.
that an elevation in IGF-II receptor levels can influence the expression profiles of transcripts as well as proteins that are involved in AD pathogenesis.
DNA methylation (zeige HELLS Antikörper) changes were noted in the Igf2r gene during chronic cystitis in a murine model.
Airn expression is both necessary and sufficient to silence Igf2r throughout embryonic stem cell differentiation.
The results excluded a role for spliced and unspliced Airn lncRNA products and for Airn nuclear size and location in silencing Igf2r. Instead, silencing only required Airn transcriptional overlap of the Igf2r promoter, which interferes with RNA polymerase II recruitment in the absence of repressive chromatin.
mannose 6-phosphate/IGF2R knock-down in receptor-positive mouse hepatocytes causes increased cathepsin secretion as well as enhanced cell motility and invasiveness
enhanced CI-MPR expression might improve the efficacy of enzyme replacement therapy in Pompe disease through enhancing receptor-mediated uptake of GAA (zeige GAA Antikörper).
The interaction of sM6P/IGF2R with Plg (zeige PLG Antikörper) may be an important regulatory mechanism to inhibit migration of cells using the uPA (zeige PLAU Antikörper)/uPAR (zeige PLAUR Antikörper) system.
Results demonstrate a novel role for IGF2R as an IFNgamma-inducible microglial protein involved in regulation of HIV and chemokine (zeige CCL1 Antikörper) expression.
IGF2R is expressed from both parental alleles although differential allelic expression may occur.
study hypothesizes that reduced granulosa cell insulin-like growth factor II receptor expression in F2 follicles of Twinner cows may play a role in the development of 2 or more dominant follicles
imprinting of Bos taurus IGF2R is similar to mouse except in placenta, which could indicate an effect of reproductive strategy
Increases in CYP19A1 (zeige CYP19A1 Antikörper) and FSHR (zeige FSHR Antikörper) mRNA expression and decreases in IGF2R mRNA expression in follicles of Twinners support the hypothesis that increased follicular development and steroidogenesis result from increased extra-ovarian IGF-1 (zeige IGF1 Antikörper) production.
Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation (zeige HELLS Antikörper) patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.
Study demonstrates associations between IGF2R polymorphisms and growth- and body-related traits in cattle.
Data describes the long-term changes to skeletal muscle growth and IGF1 (zeige IGF1 Antikörper), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Expression and binding properties of mannose-6-phosphate receptors CD-MPR (zeige M6PR Antikörper) and CI-MPR differ during perinatal development in rat liver.
the interaction between uPAR (zeige PLAUR Antikörper) and Man-6-P/IGF2R is a low percentage binding event and that suPAR and full-length uPAR (zeige PLAUR Antikörper) bind the Man-6-P/IGF2R by different mechanisms.
Results describe the crystal structure of the N-terminal 432 residues of the cation-independent mannose 6-phosphate receptor, which encompass three out of the 15 repetitive domains of its extracytoplasmic region.
CI-MPR contains a third Man-6-P recognition site that is located in domain 5 and that exhibits lower affinity than the carbohydrate-binding sites present in domains 1-3 and 9
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.
insulin-like growth factor 2 receptor
, 300 kDa mannose 6-phosphate receptor
, CI Man-6-P receptor
, IGF-II receptor
, M6P/IGF2 receptor
, MPR 300
, cation-independent mannose-6 phosphate receptor
, cation-independent mannose-6-phosphate receptor
, insulin-like growth factor II receptor
, cation-independent MPR
, cation-independent mannose 6-phosphate receptor
, mannose-6-phosphate receptor, cation independent
, cation-independent mannose 6 phosphate receptor
, insulin-like growth factor receptor type 2