anti-Insulin-Degrading Enzyme (IDE) Antikörper

IDE encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and k. Zusätzlich bieten wir Ihnen Insulin-Degrading Enzyme Kits (49) und Insulin-Degrading Enzyme Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
IDE 15925  
IDE 25700 P35559
IDE 3416 P14735
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Top anti-Insulin-Degrading Enzyme Antikörper auf antikoerper-online.de

Showing 10 out of 136 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-IDE Antibody (Center) (ABIN388241) in A375 cell line lysates (35 µg/lane). IDE (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with IDE antibody (Center)(ABIN388241), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Ziege Unkonjugiert IHC, ELISA, WB ABIN334425 (0.1µg/ml) staining of K562 cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Maus Ziege Unkonjugiert ELISA, WB ABIN190754 (1µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Ziege Unkonjugiert IHC (p), IHC, ELISA, WB ABIN261102(0.1µg/ml) staining of K562 cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Western Blot: Insulysin/IDE Antibody [ABIN2611028] - Analysis of IDE antibody using this antibody at 0.1ug/ml in K562 cell lysate. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Fledermaus Ziege Unkonjugiert IHC (p) Skeletal muscle, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Prostate, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Fledermaus Ziege Unkonjugiert IHC (p), ELISA, WB Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Hund Ziege Unkonjugiert WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$455.40
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Maus Ziege Unkonjugiert ELISA, WB ABIN253306 (1ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details

IDE Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Insulin-Degrading Enzyme Antikörper

  1. Human Polyclonal IDE Primary Antibody für IHC (p), WB - ABIN388241 : Radulescu, Fischer, Stange, Schulze: Promoting scientific standards in Germany. in Science (New York, N.Y.) 2010 (PubMed)
    Show all 6 Pubmed References

  2. Mouse (Murine) Polyclonal IDE Primary Antibody für ELISA, WB - ABIN253306 : Zhao, Xiang, Haroutunian, Buxbaum, Stetka, Pasinetti: Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. in Neurobiology of aging 2007 (PubMed)

Weitere Antikörper gegen Insulin-Degrading Enzyme Interaktionspartner

Mouse (Murine) Insulin-Degrading Enzyme (IDE) Interaktionspartner

  1. elevated IDE expression, in the skeletal muscle, seems to be mediated by activation of AMPK-ACC pathway, in response to exercise

  2. IDE inhibition did notincrease amyloid formation or beta-cell loss.

  3. This study demonstrated that the Decreased IDE and IGF2 expression in the cerebral cortex of pups by early life lead exposure.

  4. Findings show a key role of Pla2g3 (zeige PLA2G3 Antikörper) on the reduction of IDE, and suggest that cerebrum specific increase of Pla2g3 (zeige PLA2G3 Antikörper) is involved in the initiation and/or progression of Alzheimer disease.

  5. Abeta (zeige APP Antikörper) level reduction by CALHM1 (zeige CALHM1 Antikörper) could be explained by an increase in extracellular Abeta (zeige APP Antikörper) degradation by insulin-degrading enzyme.

  6. Data suggest that protein restriction down-regulates expression of insulysin (insulin degrading enzyme) in liver and subsequently reduced insulin (zeige INS Antikörper) clearance.

  7. IDE deficiency in bone marrow-derived cells results in larger atherosclerotic lesions, increased lesion-associated Abeta (zeige APP Antikörper) and RAGE (zeige AGER Antikörper), and higher serum cholesterol in male, Ldlr (zeige LDLR Antikörper)(-/-) mice.

  8. The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of alpha-synuclein levels in beta-cells.

  9. this study identified an upstream promoter element which blocks the reverse transcription of mouse IDE.

  10. Data show that in the absence of insulin-degrading enzyme (IDE), full-length calcitonin gene-related peptide (CGRP (zeige CALCA Antikörper)) levels are elevated in vivo.

Human Insulin-Degrading Enzyme (IDE) Interaktionspartner

  1. People with allelic variation in four genes related to cardiovascular diseases and metabolism were more likely to die: apolipoprotein (APO (zeige C9orf3 Antikörper))C1 GG and AG carriers, APOE (zeige APOE Antikörper) varepsilon4 carriers, insulin-degrading enzyme (IDE) TC carriers, and phosphatidylinositol 3-kinase (PI3KCB) GG carriers.

  2. Data suggest the possibility of development of insulin-degrading enzyme (IDE)-based drugs for the treatment of the late-onset form of Alzheimer's disease (AD).

  3. the mechanistic and molecular features of IDE-26S proteasome (zeige Psmd4 Antikörper) interaction in a cell experimental model, is reported.

  4. No significant associations have been found between other IDE gene single nucleotide polymorphisms of rs4646953, rs2251101 and rs1544210 with Alzheimer disease.

  5. results demonstrate that the polymorphisms rs1887922 and rs1999764 of the IDE gene are associated with late-onset Alzheimer disease susceptibility in the Xinjiang Han population

  6. Cognitive impairment is more frequent among those exposed to the C allele of the rs2209972 SNP of the insulin degrading enzyme gene.

  7. IDE does not play a major role in MHC class I antigen processing, confirming the dominant and almost exclusive role of the proteasome in cytosolic production of MHC class I ligands.

  8. using combinational in silico investigations, study identified that pathogenic nonsynonymous mutations corresponding to p.I54F, p.P122T, p.T533R, p.P581A and p.Y609A have more potential role in structural and functional deviations of IDE activity

  9. Our study provided evidence to IDE, PON1 (zeige PON1 Antikörper), WFS1 (zeige WFS1 Antikörper), POU2F1 (zeige POU2F1 Antikörper), IL1alpha (zeige IL1A Antikörper) and IL1beta (zeige IL1B Antikörper) associated with T2D in Pakistanis.

  10. An upstream promoter element which blocks the antisense transcription of the human IDE promoter, was identified.

Insulin-Degrading Enzyme (IDE) Antigen-Profil

Protein Überblick

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Genbezeichner und Symbole assoziert mit IDE

  • insulin degrading enzyme (IDE) Antikörper
  • insulin-degrading enzyme (ide) Antikörper
  • insulin-degrading enzyme (LOC591315) Antikörper
  • insulin-degrading enzyme (CC1G_01115) Antikörper
  • insulin-degrading enzyme (Bm1_26615) Antikörper
  • insulin-degrading enzyme (PTRG_10875) Antikörper
  • metallopeptidase (SJAG_01430) Antikörper
  • insulin-degrading enzyme (EBI_21700) Antikörper
  • insulin-degrading enzyme (VDBG_06702) Antikörper
  • insulin-degrading enzyme (LOAG_08082) Antikörper
  • insulin-degrading enzyme (PGTG_04982) Antikörper
  • insulin-degrading enzyme (Tsp_00424) Antikörper
  • insulin degrading enzyme (Ide) Antikörper
  • 1300012G03Rik Antikörper
  • 4833415K22Rik Antikörper
  • AA675336 Antikörper
  • AI507533 Antikörper
  • IDE Antikörper
  • INSDEGM Antikörper
  • INSULYSIN Antikörper
  • zgc:162603 Antikörper

Bezeichner auf Proteinebene für IDE

insulysin , insulin-degrading enzyme , insulin-degrading enzyme-like , insulin protease , insulinase , Abeta-degrading protease

GENE ID SPEZIES
450608 Pan troglodytes
561390 Danio rerio
591315 Strongylocentrotus purpuratus
698640 Macaca mulatta
6009544 Coprinopsis cinerea okayama7130
6100223 Brugia malayi
6349187 Pyrenophora tritici-repentis Pt-1C-BFP
7051385 Schizosaccharomyces japonicus yFS275
8641122 Enterocytozoon bieneusi H348
9537184 Verticillium alfalfae VaMs.102
100071303 Equus caballus
100385143 Callithrix jacchus
100434053 Pongo abelii
100482236 Ailuropoda melanoleuca
9945508 Loa loa
10530847 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10901673 Trichinella spiralis
15925 Mus musculus
25700 Rattus norvegicus
3416 Homo sapiens
477768 Canis lupus familiaris
100341888 Oryctolagus cuniculus
100719651 Cavia porcellus
423814 Gallus gallus
100155309 Sus scrofa
523752 Bos taurus
101104194 Ovis aries
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