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IDE Antikörper (AA 485-756)

IDE Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, ICC, FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5693119
  • Target Alle IDE Antikörper anzeigen
    IDE (Insulin-Degrading Enzyme (IDE))
    Bindungsspezifität
    • 16
    • 8
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 485-756
    Reaktivität
    • 62
    • 26
    • 23
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 51
    • 10
    • 4
    Kaninchen
    Klonalität
    • 55
    • 10
    Polyklonal
    Konjugat
    • 36
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IDE Antikörper ist unkonjugiert
    Applikation
    • 58
    • 26
    • 18
    • 14
    • 13
    • 12
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Marke
    Picoband™
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for IDE detection. Tested with WB, IHC-P, IHC-F, ICC, FCM, Direct ELISA in Human,Mouse,Rat.
    Immunogen
    E. coli-derived human IDE recombinant protein (Position: F485-K756).
    Top Product
    Discover our top product IDE Primärantikörper
  • Applikationshinweise

    Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P), IHC(F) and ICC.

    Application Details: Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry(Paraffin-embedded Section), 0.5-1 μg/mL
    Immunohistochemistry(Frozen Section), 0.5-1 μg/mL
    Immunocytochemistry, 0.5-1 μg/mL
    Flow Cytometry, 1-3 μg/1x106 cells
    Direct ELISA, 0.1-0.5 μg/mL

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
  • Target
    IDE (Insulin-Degrading Enzyme (IDE))
    Andere Bezeichnung
    IDE (IDE Produkte)
    Synonyme
    zgc:162603 antikoerper, IDE antikoerper, 1300012G03Rik antikoerper, 4833415K22Rik antikoerper, AA675336 antikoerper, AI507533 antikoerper, INSDEGM antikoerper, INSULYSIN antikoerper, insulin degrading enzyme antikoerper, insulin-degrading enzyme antikoerper, metallopeptidase antikoerper, IDE antikoerper, ide antikoerper, LOC591315 antikoerper, CC1G_01115 antikoerper, Bm1_26615 antikoerper, PTRG_10875 antikoerper, SJAG_01430 antikoerper, EBI_21700 antikoerper, VDBG_06702 antikoerper, LOAG_08082 antikoerper, PGTG_04982 antikoerper, Tsp_00424 antikoerper, Ide antikoerper
    Hintergrund

    Synonyms: Insulin-degrading enzyme, Abeta-degrading protease, Insulin protease, Insulinase, Insulysin, IDE

    Background: Insulin-degrading enzyme, also known as IDE, is an enzyme. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

    UniProt
    P14735
    Pathways
    SARS-CoV-2 Protein Interaktom
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