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The protein encoded by FGL2 is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. Zusätzlich bieten wir Ihnen Fibrinogen-Like 2 Antikörper (94) und Fibrinogen-Like 2 Proteine (20) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) FGL2 ELISA Kit für Sandwich ELISA - ABIN415690
Chen, Wu, Guo, Fei, Guo, Yang, Fu, Wu: Programmed death (PD)-1-deficient mice are extremely sensitive to murine hepatitis virus strain-3 (MHV-3) infection. in PLoS pathogens 2011
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Human FGL2 ELISA Kit für Sandwich ELISA - ABIN414678
Colak, Senates, Ozturk, Yilmaz, Coskunpinar, Kahraman, Sahin, Zemheri, Enc, Ulasoglu, Kiziltas, Kurdas, Tuncer: Plasma fibrinogen-like protein 2 levels in patients with non-alcoholic fatty liver disease. in Hepato-gastroenterology 2012
Our results identified FGL2, GAL (zeige GAL ELISA Kits), SEMA4D (zeige SEMA4D ELISA Kits), SEMA7A (zeige SEMA7A ELISA Kits), and IDO1 (zeige IDO1 ELISA Kits) as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2, GAL (zeige GAL ELISA Kits), SEMA4D (zeige SEMA4D ELISA Kits), SEMA7A (zeige SEMA7A ELISA Kits), and IDO1 (zeige IDO1 ELISA Kits) genes appeared to be differentially transcribed in the different MSC (zeige MSC ELISA Kits) populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals
Report increased expression of FGL-2 in peripheral blood mononuclear cells from mycosis fungoides patients.
these results suggest that FGL-2 mediates angiogenesis and tumorigenesis not by thrombin (zeige F2 ELISA Kits)-mediated mechanism but rather through FGF-2 (zeige FGF2 ELISA Kits)/ERK (zeige EPHB2 ELISA Kits) signaling pathway.
Results show that FGL2 functions as a key immune-suppressive modulator and has potential as an immunotherapeutic target for treating glioblastoma multiforme (GBM).
FGL-2 prothrombinase (zeige F10 ELISA Kits) activity in PBMC of lymphoma patients is increased in active disease and normalizes during remission, thus being a potential marker for follow up of lymphoma patients.
Studied fibrinogen-like protein 2 expression and its role in CRC (zeige CALR ELISA Kits) metastasis and underlying molecular mechanisms; results suggest that FGL2 plays an important oncogenic role in CRC (zeige CALR ELISA Kits) aggressiveness by inducing EMT (zeige ITK ELISA Kits).
The selected peptide sequence NPG (zeige OPA1 ELISA Kits)-12 may be a critical domain for hfgl2 prothrombinase (zeige F10 ELISA Kits) activity.
The proliferation index of CD8 (zeige CD8A ELISA Kits)(+)T cells after blocking FGL2 was higher.
immunomodulatory activity of FGL2 may be involved in the immunopathogenesis of inflammatory bowel disease
Circulating fibrinogen-like protein 2 is increased in patients with systemic sclerosis.
soluble FGL2 might be a potential renoprotective mediator involved in the renal self-repairing and remodeling.
studies of pig-to-baboon kidney xenografts undergoing acute vascular rejection in vivo revealed induction of pfgl2 expression on graft vascular endothelial cells.
In vitro IL-33 (zeige IL33 ELISA Kits) treatment abrogated MHV-3 and IFN-gamma induced (zeige SAMHD1 ELISA Kits) FGL2 expression in RAW264.7 and THP-1 (zeige GLI2 ELISA Kits) cells.
FGL2 appears as one of the key players in immune regulatory processes favoring metacestode survival by promoting Regulatory T-cell activity and IL-17A (zeige IL17A ELISA Kits) production that contributes to FGL2-regulation.
TNF-alpha (zeige TNF ELISA Kits), and FGL2 form an integral network that contributes to coagulation and complement activation, and suggest that those are potential therapeutic targets in viral FH intervention.
these data strongly suggest that Treg cells expressing FGL2 mediate rapamycin-induced tolerance. Furthermore, a gene biomarker panel that includes fgl2 can distinguish between rejecting and tolerant grafts.
Mouse susceptibility to MHV-3-induced fulminant hepatitis may rely on C5a/C5aR interactions, for which ERK1/2 (zeige MAPK1/3 ELISA Kits) and p38 (zeige CRK ELISA Kits) pathways participate in up-regulating Fgl2 expression.
Targeted deletion of FGL2 leads to increased early viral replication and enhanced adaptive immunity in a murine model of acute viral hepatitis.
Cysteines at positions 94, 97, 184 and 187, found in the coiled-coil domain were shown to be crucial for FGL2 oligomerization.
FGL2 binding to the FcgammaRIIB receptor expressed on sinusoidal endothelial cells (SECs) is a critical event in the initiation of the hepatic reperfusion injury cascade through induction of SEC and hepatocyte death.
The prothrombinase activity of FGL2 contributes to the pathogenesis of experimental arthritis.
Fgl2 cleaves prothrombin (zeige F2 ELISA Kits) to thrombin (zeige F2 ELISA Kits) consistent with serine protease (zeige F2 ELISA Kits) activity and requires calcium, phospholipids, and factor Va for its full activity.
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites.
, fibrinogen-like protein 2
, associated with MHV-3 induced prothrombinase activity
, cytotoxic T-lymphocyte-specific protein