Ectonucleotide Pyrophosphatase/phosphodiesterase 2 Proteine (ENPP2)

The protein encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. Zusätzlich bieten wir Ihnen ENPP2 Antikörper (119) und ENPP2 Kits (23) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ENPP2 5168 Q13822
ENPP2 18606 Q9R1E6
ENPP2 84050 Q64610
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Top ENPP2 Proteine auf antikoerper-online.de

Showing 10 out of 14 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Cynomolgus His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
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HOST_Human Cells Human His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
Details
HOST_Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
792,38 €
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HOST_HEK-293 Cells Human His tag   10 μg Anmelden zum Anzeigen 6 bis 8 Tage
261,90 €
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HOST_HEK-293 Cells Human His tag Human ENPP-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
360,00 €
Details
HOST_HEK-293 Human His tag   0.05 mg Anmelden zum Anzeigen 6 bis 8 Tage
603,70 €
Details
Hefe Yeast His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.100,95 €
Details

ENPP2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, ,
Mouse (Murine) , ,

Rat (Rattus)

Am meisten referenzierte ENPP2 Proteine

  1. Human ENPP2 Protein expressed in Human Cells - ABIN2004207 : Boucher, Quilliot, Pradères, Simon, Grès, Guigné, Prévot, Ferry, Boutin, Carpéné, Valet, Saulnier-Blache: Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. in Diabetologia 2005 (PubMed)
    Zeige alle 2 Referenzen für 2004207

Weitere Proteine zu Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartnern

Xenopus laevis Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartner

  1. Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.

Human Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartner

  1. These findings suggest that the promoter hypomethylation and overexpression of ATX might play a contributory role in the pathogenesis of liver fibrosis in biliary atresia.

  2. LPA2 mRNA levels were associated with poorer differentiation, and higher LPA6 levels were associated with microvascular invasion in HCC; both became a risk factor for recurrence after surgical treatment when combined with increased serum ATX levels

  3. AKT (zeige AKT1 Proteine) signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell (zeige NFATC3 Proteine)-mediated p23 (Sec24C (zeige SEC24C Proteine)) expression

  4. Expression of both ATX and IL-6 was increased in systemic scleroderma (SSc) skin, and lysophosphatidic acid-induced IL-6 levels and IL (zeige CYP11A1 Proteine)-6-induced ATX levels were increased i (zeige CYP11A1 Proteine)n fibroblasts from SSc patients compared with (zeige IL6 Proteine) controls.

  5. Elevated levels of autotaxin and soluble markers of immune activation during HCV infection.

  6. These results suggest that the post-transcriptional regulation of ATX expression by HuR (zeige ELAVL1 Proteine) and AUF1 (zeige HNRNPD Proteine) modulates cancer cell migration.

  7. ATX is highly expressed in renal cell carcinoma (zeige MOK Proteine) and bladder carcinoma.

  8. With a deeper understanding of the critical role of the autotaxin/lysophosphatidate axis in pancreatic cancer, targeting autotaxin or lysophosphatidate receptor may be a potential and promising strategy for cancer therapy.

  9. Plasma ATX activity is strongly associated with pruritus in primary biliary cholangitis, authors review the biochemistry of ATX and the rationale for its role in pruritus. [Review]

  10. Data suggest serum ATX levels correlate with presence/intensity of pruritus in pediatric cholestatic disorders; despite therapy, ATX is up-regulated in children with severe pruritus due to cholestatic disorders (AGS (zeige JAG1 Proteine), Alagille syndrome; BA, biliary atresia; progressive familial intrahepatic cholestasis) compared to children with cholestatic disorders without pruritus (BASD, bile acid synthesis defects). [PILOT PROJECT]

Mouse (Murine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartner

  1. This study showed that alternative autotaxin-independent pathways are likely responsible for local generation of lysophosphatidic acid in the injured lung.

  2. Hepatocyte autotaxin expression promotes liver fibrosis and liver cancer.

  3. These results indicate that ATX-lysophosphatidic acid-LPA3 (zeige LPAR3 Proteine) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF (zeige HBEGF Proteine) and COX-2 pathways.

  4. ATX is required for the development and maintenance of dermal fibrosis in a mouse model of bleomycin-induced systemic scleroderma (SSc (zeige CYP11A1 Proteine)) and enables 2 major mediators of SSc (zeige CYP11A1 Proteine) fibrogenesis, lysophosphatidic acid and IL-6 (zeige IL6 Proteine), to amplify the production of each other.

  5. These results suggest that the post-transcriptional regulation of ATX expression by HuR (zeige ELAVL1 Proteine) and AUF1 (zeige HNRNPD Proteine) modulates cancer cell migration.

  6. inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.

  7. findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation

  8. Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer

  9. These findings identify ATX and LPA2 (zeige LPAR2 Proteine) as radiation-regulated genes that appear to play a physiological role in DNA repair.

  10. The results are discussed in terms of ATX regulation in wound healing and cancer.We, therefore, demonstrate the concept that accumulation of LPA in the circulation decreases ATX production

Pig (Porcine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartner

  1. ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.

Cow (Bovine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartner

  1. These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.

ENPP2 Protein Überblick

Protein Überblick

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.

Genbezeichner und Symbole assoziert mit ENPP2

  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (enpp2)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2)
  • ATX Protein
  • ATX-X Protein
  • AUTOTAXIN Protein
  • LysoPLD Protein
  • MGC132047 Protein
  • NPP2 Protein
  • Npps2 Protein
  • PD-Ialpha Protein
  • Pdnp2 Protein
  • zgc:63550 Protein

Bezeichner auf Proteinebene für ENPP2

autotaxin , ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) , ectonucleotide pyrophosphatase/phosphodiesterase 2 , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 , E-NPP 2 , autotaxin-t , extracellular lysophospholipase D , phosphodiesterase I/nucleotide pyrophosphatase 2 , plasma lysophospholipase D , lysoPLD , phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin) , atx

GENE ID SPEZIES
100057101 Equus caballus
464353 Pan troglodytes
548690 Xenopus (Silurana) tropicalis
705287 Macaca mulatta
735240 Xenopus laevis
100173553 Pongo abelii
100219257 Taeniopygia guttata
5168 Homo sapiens
18606 Mus musculus
84050 Rattus norvegicus
393575 Danio rerio
420361 Gallus gallus
482026 Canis lupus familiaris
503658 Sus scrofa
532663 Bos taurus
Ausgewählte Anbieter für ENPP2 Proteine (ENPP2)
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