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The protein encoded by DARC is a glycosylated membrane protein and a non-specific receptor for several chemokines. Zusätzlich bieten wir Ihnen DARC Proteine (8) und DARC Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 142 products:
Human Polyclonal DARC Primary Antibody für ELISA, FACS - ABIN250822
Zeng, Ou, Yu, Feng, Yin, Li, Shen, Shao: Coexpression of atypical chemokine binders (ACBs) in breast cancer predicts better outcomes. in Breast cancer research and treatment 2011
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Human Polyclonal DARC Primary Antibody für WB - ABIN1881251
Silva, Blanton, Parrado, Melo, Morato, Reis, Dias, Castro, Vasconcelos, Goddard, Barreto, Reis, Teixeira: Dengue hemorrhagic fever is associated with polymorphisms in JAK1. in European journal of human genetics : EJHG 2010
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Human Polyclonal DARC Primary Antibody für ELISA, IHC - ABIN4304289
Gardner, Patterson, Ashton, Stone, Middleton: The human Duffy antigen binds selected inflammatory but not homeostatic chemokines. in Biochemical and biophysical research communications 2004
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Human Polyclonal DARC Primary Antibody für IHC, ELISA - ABIN1002191
Chaudhuri, Polyakova, Zbrzezna, Williams, Gulati, Pogo: Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. in Proceedings of the National Academy of Sciences of the United States of America 1993
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Human Polyclonal DARC Primary Antibody für IHC (p), WB - ABIN2479381
Murthy, Saxena: Investigations on sarcolemmal ATPase activities in ventricular tissues of swimming trained & sedentary rats. in Indian journal of experimental biology 1979
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The data suggest that selective exposure of the Duffy binding protein (DBP (zeige GC Antikörper)) binding site within DARC is key to the preferential binding of DBP (zeige GC Antikörper) to immature reticulocytes, which is the potential mechanism underlying the preferential infection of a reticulocyte subset by P vivax.
population genetic analysis of DARC shows its association with malaria resistance
We showed that DARC expression is down-regulated in CRC (zeige CALR Antikörper) and associated with clinical pathological features and MVD (zeige MVD Antikörper) of CRC (zeige CALR Antikörper). DARC might be involved in tumorigenesis, progression, angiogenesis, and metastasis of CRC (zeige CALR Antikörper).
DARC is required for Staphylococcus aureus-mediated lysis of human erythrocytes, and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis.
study demonstrates the association of SNP rs12075 from DARC gene with the levels of serum IL8 (zeige IL8 Antikörper)
DARC levels are elevated in human keloid fibroblasts and might inhibit the secretion of CCL2 (zeige CCL2 Antikörper).
Through molecular genotyping we also identified polymorphisms in RhCE (zeige RHCE Antikörper), Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.
Duffy blood group
Isothermal titration calorimetry studies show these structures are part of a multi-step binding pathway, and individual point mutations of residues contacting DARC result in a complete loss of RBC (zeige CACNA1C Antikörper) binding by DBP (zeige GC Antikörper)-RII.
DARC polymorphisms may influence the naturally acquired inhibitory anti-Duffy binding protein II (zeige ANXA4 Antikörper) immunity
DARC regulates recruitment of osteoclast precursors at the inflammation site
The DARC/CD234 is expressed on macrophages and stabilizes CD82 (zeige CD82 Antikörper) on long-term repopulating hematopoietic stem cells, promoting their quiescence.
Ackr1 deficiency appears to be protective in the ApoE (zeige APOE Antikörper) knockout model of atherogenesis, but it is associated with only modest changes in cytokine and chemokine (zeige CCL1 Antikörper) expression as well as T-cell subset frequency and inflammatory macrophage content.
Darc plays a role in modulating the regulation of inflammatory response to bone injury and that lack of Darc expression promotes cartilage formation in fracture calluses but does not affect bony union or fracture healing at 21 days post-fracture.
The data showed a role for erythrocyte DARC as a chemokine (zeige CCL1 Antikörper) reservoir and that endothelial DARC contributes to the pathogenesis of experimental autoimmune encephalomyelitis by shuttling chemokines across the blood-brain barrier.
DARC is crucial for chemokine (zeige CCL1 Antikörper)-mediated leukocyte recruitment in vivo.
Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion.
Vascular endothelial cells may induce Duffy protein to regulate leukocytes and/or chemokine (zeige CCL1 Antikörper) trafficking
role of the Duffy antigen and glycophorin A (zeige GYPA Antikörper) as receptors for rodent malaria parasite invasion of erythrocytes
DARC functions to clear angiogenic CXC chemokines from the prostate tumor microcirculation
the 5' flanking region of the DARC gene was isolated and characterized
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene.
Duffy blood group, chemokine receptor
, duffy antigen/chemokine receptor
, Duffy antigen/chemokine receptor
, Duffy blood group antigen
, Fy glycoprotein
, atypical chemokine receptor 1
, glycoprotein D
, plasmodium vivax receptor
, Duffy antigen receptor for chemokines
, blood group antigen
, duffy antigen/receptor for chemokine glycoprotein