Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) Proteine (CFTR)

CFTR encodes a member of the ATP-binding cassette (ABC) transporter superfamily. Zusätzlich bieten wir Ihnen CFTR Antikörper (233) und CFTR Kits (33) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CFTR 12638 P26361
Ratte CFTR CFTR 24255 P34158
CFTR 1080 P13569
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Showing 4 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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CFTR Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
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Human ,
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Weitere Proteine zu Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartnern

Xenopus laevis Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. NDPK-A (zeige NME1 Proteine) exists in a functional cellular complex with AMPK (zeige PRKAA2 Proteine) and CFTR in airway epithelia, and NDPK-A (zeige NME1 Proteine) catalytic function is required for the AMPK (zeige PRKAA2 Proteine)-dependent regulation of CFTR

  2. Study conclude that when both CFTR and NPT2a (zeige SLC34A1 Proteine) are expressed in X. laevis oocytes, CFTR confers to NPT2a (zeige SLC34A1 Proteine) a cAMPi-dependent trafficking to the membrane.

  3. wild-type CFTR channel gating cycle is essentially irreversible and tightly coupled to the ATPase cycle, and that this coupling is completely destroyed by the NBD2 Walker B mutation D1370N but only partially disrupted by the NBD1 Walker A mutation K464A.

  4. The cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that belongs to the superfamily of ATP binding cassette (ABC (zeige ABCB6 Proteine)) transporters.

  5. These data suggest that the Xenopus P2Y1 receptor (zeige P2RY1 Proteine) can increase both cyclic AMP (zeige TMPRSS5 Proteine)/protein kinase A and calcium/protein kinase C levels and that the PKC pathway is involved in CFTR activation via potentiation of the PKA pathway.

Mouse (Murine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. a new and more convenient approach, based on in vivo imaging analysis, has been set up to evaluate the inflammatory response in the lung of CFTR-deficient (CF) mice, a murine model of cystic fibrosis (zeige S100A8 Proteine).

  2. results reveal that by potentiating adenosine triphosphate-sensitive K+ (KATP) channel, cystic fibrosis transmembrane conductance regulator CFTR acts as a glucose-sensing negative regulator of glucagon (zeige GCG Proteine) secretion in alpha cells

  3. This study demonstrates that CFTR plays an important role in tenogenic differentiation and tendon regeneration by inhibiting the beta-catinin/pERK1/2 signaling pathway.

  4. CFTR is a tumor suppressor gene in murine and human colorectal cancer

  5. Insulin (zeige INS Proteine) stimulation of Akt1 (zeige AKT1 Proteine) and Akt2 (zeige AKT2 Proteine) signaling in Cystic fibrosis (zeige S100A8 Proteine) airway cells was diminished compared with that observed in airway cells expressing wild-type CFTR.

  6. Biotinylation and streptavidin pull-down assays confirmed that CAL (zeige S100A11 Proteine) dramatically reduces the expression level of total and cell surface Mrp2 (zeige ABCC2 Proteine) in Huh-7 cells. Our findings suggest that CAL (zeige S100A11 Proteine) interacts with Mrp2 (zeige ABCC2 Proteine) and is a negative regulator of Mrp2 (zeige ABCC2 Proteine) expression.

  7. Myelinosomes secreted from testis somatic TM4 (zeige TPM4 Proteine) Sertoli cells provide the release of aggregate-prone mutant, but not normal Huntingtin (Htt (zeige HTT Proteine)) exon1. Myelinosomes also support the release of other aggregate-prone mutant protein responsible for cystic fibrosis (zeige S100A8 Proteine) (CF), F508delCFTR.

  8. ATP8B1 (zeige ATP8B1 Proteine) is important for proper CFTR expression and function.

  9. Loss of cystic fibrosis (zeige S100A8 Proteine) transmembrane regulator impairs intestinal oxalate secretion

  10. CFTR plays a role in suppressing MAPK (zeige MAPK1 Proteine)/NF-kappaB (zeige NFKB1 Proteine) to relieve inflammation, reduce proliferation and promote differentiation of keratinocytes, and thus promotes cutaneous wound healing.

Human Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. The effect of complex alleles partially depends on the mutation in trans. Although larger studies are necessary, the CFTR activity on nasal epithelial cells is a rapid contributory tool to classify patients with CFTR dysfunction.

  2. Chloride anion behaves as a signaling effector for CFTR in the modulation of RPS27 (zeige RPS27 Proteine) expression.

  3. Variations in CFTR gene is associated with cystic fibrosis (zeige S100A8 Proteine).

  4. proteostasis regulator cysteamine, which rescues the function of the most common F508del-CFTR mutant and hence reduces lung inflammation in CF patients, can also repair the defects of CF macrophages, thus restoring both bacterial internalization and clearance through a process that involves upregulation of the pro-autophagic protein Beclin 1 (zeige BECN1 Proteine) and re-establishment of the autophagic pathway.

  5. CFTR correctors are strong candidates for the treatment of Sjogren's syndrome and pancreatitis, since correcting ductal function is sufficient to rescue acinar cell function in salivary glands and pancreas.

  6. results suggest that cystic fibrosis transmembrane conductance regulator (CFTR) affects beta-cell function via a paracrine mechanism involving proinflammatory factors secreted from islet-associated exocrine-derived cell types

  7. Molecular dynamics of the cryo-EM CFTR structure

  8. This study demonstrates that CFTR plays an important role in tenogenic differentiation and tendon regeneration by inhibiting the beta-catinin/pERK1/2 signaling pathway.

  9. report the interaction between CFTR and HDAC2 (zeige HDAC2 Proteine), and its involvement in the development of Ph+ leukemia

  10. Vmax for wild-type CFTR was 240+/-60nmol/min/mg.

Pig (Porcine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Results suggest that acetylcholine does not regulate the activity of the CFTR in tracheal epithelia of pigs which opposes observation from studies using mice airway epithelium.

  2. Expression of CFTR-F508del interferes with smooth muscle cell calcium handling and decreases aortic responsiveness.

  3. Pseudomonas aeruginosa and other bacteria into the lumen of intact isolated swine tracheas triggers CFTR-dependent airway surface liquid secretion by the submucosal glands.

  4. TGF-beta1 (zeige TGFB1 Proteine), via TGF-beta1 (zeige TGFB1 Proteine) receptor I and p38 MAPK (zeige MAPK14 Proteine) signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility.

  5. The esophageal submucosal glands (SMG (zeige SNRPG Proteine)) secrete HCO(3)(-) and mucus into the esophageal lumen, where they contribute to acid clearance and epithelial protection. We investigated the presence of CFTR, its involvement in the secretion process, and the effect of cAMP on HCO3 secretion in this tissue. This is the first report on the presence of CFTR channels in the esophagus.

  6. data suggest that loss of CFTR directly alters Schwann cell function and that some nervous system defects in people with cystic fibrosis (zeige S100A8 Proteine) are likely primary

  7. The data suggest, that during bacterial infections and resulting release of proinflammatory cytokines, the glands are stimulated to secrete fluid, and this response is mediated by cAMP-activated CFTR.

  8. CFTR is required for maximal liquid absorption by lung alveoli under cAMP stimulation

  9. These findings reveal differences between nasal and tracheal glands, show defective fluid secretion in nasal glands of cystic fibrosis (zeige S100A8 Proteine) pigs, reveal some spared function in the DeltaF508 vs. null piglets.

  10. causal link between CFTR mutations and partial or total vas (zeige AVP Proteine) deferens and/or epididymis atresia at birth

Cow (Bovine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. conserved CFTR sequences between species are examined for potential regulatory elements. Regions of introns 2, 3, 10, 17a, 18, and 21 and 3' flanking sequence corresponding to human CFTR DNase I (zeige DNASE1 Proteine) hypersensitive sites showed high homology in cow and pig.

Guinea Pig Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Results demonstrate functional coupling between Cftr and Slc26a6 (zeige SLC26A6 Proteine)-like Cl(-)/HCO(3)(-) exchange activity in apical membrane of guinea pig pancreatic interlobular duct.

CFTR Protein Überblick

Protein Überblick

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.

Genbezeichner und Symbole assoziert mit CFTR

  • cystic fibrosis transmembrane conductance regulator (cftr-A)
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR)
  • cystic fibrosis transmembrane conductance regulator (Cftr)
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (Cftr)
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (cftr)
  • cystic fibrosis transmembrane conductance regulator homolog (Cftr)
  • abc35 Protein
  • abcc7 Protein
  • AW495489 Protein
  • CF Protein
  • CFTR Protein
  • cftr/mrp Protein
  • dJ760C5.1 Protein
  • mrp7 Protein
  • RGD1561193 Protein
  • tnr-cftr Protein
  • xcftr Protein

Bezeichner auf Proteinebene für CFTR

cystic fibrosis transmembrane conductance regulator , cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) , cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) , ATP-binding cassette sub-family C member 7 , ATP-binding cassette transporter sub-family C member 7 , ATP-binding cassette, subfamily c, member 7 , cAMP-dependent chloride channel , channel conductance-controlling ATPase , cystic fibrosis transmembrane conductance regulator homolog , cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7 , CFTR chloride channel , chloride channel , CFTR cAMP-dependent chloride channel protein , Channel conductance-controlling ATPase

GENE ID SPEZIES
373725 Xenopus laevis
780954 Monodelphis domestica
100137161 Nomascus leucogenys
12638 Mus musculus
24255 Rattus norvegicus
1080 Homo sapiens
100049619 Gallus gallus
492302 Canis lupus familiaris
403154 Sus scrofa
281067 Bos taurus
100009471 Oryctolagus cuniculus
100719898 Cavia porcellus
100071259 Equus caballus
443347 Ovis aries
100381094 Xenopus laevis
100137035 Pongo abelii
463674 Pan troglodytes
100126675 Papio anubis
100135647 Cavia porcellus
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