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Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Zusätzlich bieten wir Ihnen C5AR1 Antikörper (274) und C5AR1 Kits (12) und viele weitere Produktgruppen zu diesem Protein an.
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Human C5AR1 Protein expressed in Wheat germ - ABIN1347567
Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014
C5aR1 facilities the pathogenesis of chronic kidney infection by enhancement of bacterial colonization of tubular epithelium, promotion of local inflammatory responses, and impairment of phagocytic function of monocytes/macrophages.
Data indicate that complement component 5a receptor 1 protein (C5aR1) signaling in osteoblasts plays a detrimental role in bone regeneration after fracture.
The role of C5aR1 and C5aR2 in response to renal ischemia-reperfusion injury is reported. The results also demonstrated that C5aR2 is a functional receptor, rather than a decoy receptor, and may provide a new target for intervention.
these data reveal a differential role for C5aR during ethanol-induced liver inflammation and injury
These findings demonstrate a complex regulation pattern of C5aR1 in the airways, lung tissue and mediastinal lymph nodes of mice, suggesting that the C5a/C5aR1 axis controls airway constriction and inflammation through activation of myeloid cells in all three compartments in an experimental model of allergic asthma.
C5aR1-KO mice exhibited less renal injury, as evidenced by reduced albuminuria. In contrast, cardiac injury was accelerated with increased cardiac fibrosis and heart weight in C5aR1-deficient mice after ANG II (zeige AGT Proteine) infusion. No effect was found on blood pressure. the C5a:C5aR1 axis drives end-organ damage in the kidney but protects from the development of cardiac fibrosis and hypertrophy in experimental hypertension.
This study demonstrated that C5aR1 contributes to the acute inflammatory response elicited by infiltrating immune cells following pilocarpine status epilepticus.
Regulation of complement 5a receptor (C5aR)-induced neutrophil chemotaxis via IgG1 immune complexes (ICs (zeige DNAI1 Proteine)) depends on galectin-3 (zeige LGALS3 Proteine).
The C5a/C5aR pathway is essential for up-regulating SphK1 (zeige SPHK1 Proteine) expression through p38 MAPK (zeige MAPK14 Proteine) activation in acute liver failure.in mice.
C5a bidirectionally amplifies TLR4 (zeige TLR4 Proteine)-mediated NLRP3 (zeige NLRP3 Proteine) inflammasome activation in monocytes while suppressing this pathway in macrophages. However, as C5aR1 deficiency attenuates the IL-1beta (zeige IL1B Proteine) response to LPS (zeige TLR4 Proteine) challenge in vivo, results suggest overall that C5a augments physiologic inflammasome responses.
TLR4 (zeige TLR4 Proteine) and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2 (zeige RPS6KA3 Proteine), PI3Kbeta, SGK1 (zeige SGK1 Proteine), and FOXO (zeige FOXO3 Proteine) transcription factors.
Results showed that 7-oxygenated cholesterol derivatives have differential effects on monocyte/macrophage expression of IL-8 (zeige IL8 Proteine) and C5a receptor and that C5a receptor is involved in 7alphaOHChol-induced IL-8 (zeige IL8 Proteine) expression via PI3K (zeige PIK3CA Proteine) and MEK (zeige MAP2K1 Proteine). Study demonstrated expression of IL-8 (zeige IL8 Proteine) and C5a receptor primarily by 7alpha-hydroxycholesterol in monocytes/macrophages.
Reducing RPS19 (zeige RPS19 Proteine) in tumor cells or blocking the C5a receptor 1-RPS19 (zeige RPS19 Proteine) interaction decreases RPS19 (zeige RPS19 Proteine)-mediated immunosuppression, impairs tumor growth, and delays the development of tumors in a transgenic model of breast cancer
C5aR expression in gastric cancer was associated with cancer progression, liver metastasis, and poor prognosis.
this study shows that downregulation of CD88 after stimulation with IL-8 (zeige IL8 Proteine) is more pronounced in adults than in neonates, whereas fMLP (zeige FPR1 Proteine) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults
Relation of C5aR expression to tumor development and poor prognosis of the breast cancer patients
The objective of the present study was to validate a receptor occupancy (RO) assay for a human anti-C5aR monoclonal antibody drug candidate, NNC0215-0384 (NN0384)
These data thus suggest that C5aR1 acts as an enhancer of CCR5-mediated HIV entry into macrophages, the targeting of which may prove useful to reduce HIV infection by R5 strains.
C5AR and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.
that C5aR stimulates cell invasion and migration via ERK1/2-mediated epithelial-mesenchymal transition in hepatocellular carcinoma cells
Studies provide information regarding distinct structural and functional features that may contribute to the unique pharmacological properties of bovine C5aR.
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
complement component 5a receptor 1
, C5a anaphylatoxin receptor
, G protein-coupled receptor 77
, C5a anaphylatoxin chemotactic receptor 1
, C5a ligand
, complement component 5, receptor 1
, complement component 5 receptor 1
, complement C5a receptor
, anaphylatoxin C5a receptor
, complement component 5 receptor 1 (C5a ligand)
, C5a anaphylatoxin chemotactic receptor