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COLEC11 encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Zusätzlich bieten wir Ihnen COLEC11 Kits (16) und COLEC11 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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The exclusion of the MASP1 (zeige MASP1 Antikörper) and COLEC11 Loci in two individuals from different consanguineous families and the absence of mutations in four further individuals sequenced for both genes raises the possibility that that there is further genetic heterogeneity of 3MC syndrome
identify collectin (zeige MBL2 Antikörper) CL-LK as a novel soluble C-type lectin (zeige MBL2 Antikörper) able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK
Data indicate differences in the plasma concentrations of collectin liver 1 (zeige COLEC10 Antikörper) and collectin (zeige MBL2 Antikörper) kidney 1 (zeige ZNF354A Antikörper), M-ficolin (zeige FCN1 Antikörper) and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls.
promoter polymorphism COLEC11-9570C>T (rs3820897) was associated with decreased levels of CL-K1.
the sugar specificity of CL-K1 was established.
These results suggest that specific diseases may affect CL-K1 synthesis in an organ dependent manner and that elevated plasma CL-K1 levels are associated with the presence of DIC (zeige SLC25A10 Antikörper).
Most plasma CL-K1 was found in complex with CL-L1 (zeige COLEC10 Antikörper) in a ratio suggesting a heteromeric subunit of 1 CL-L1 (zeige COLEC10 Antikörper) & 2 CL-K1 polypeptides. It associated with MASPs 1, 2 & 3. On binding mannan or DNA in the presence of MASP-2 (zeige MASP2 Antikörper), the complex deposited C4b (zeige C4B Antikörper).
Data suggest that collectin 11 (CL-11), e.g. via complement, may play a role in response to particles and surfaces presenting extracellular DNA, such as apopototic cells.
collectin-11 associates with all the known MBL (zeige MBL2 Antikörper)-associated serine proteases (MASP-1 (zeige MASP1 Antikörper), MASP-2 (zeige MASP2 Antikörper) and MASP-3 (zeige MASP1 Antikörper)) as well as the lectin complement pathway regulator MAP-1 (zeige MASP1 Antikörper).
Data show that the concentration of collectin (zeige MBL2 Antikörper) kidney 1 (zeige ZNF354A Antikörper) (CL-K1, COLEC11) in plasma was 0.34 +/- 0.13 microg/ml and that in mannan-binding lectin (MBL (zeige MBL2 Antikörper)) was 1.72 +/- 1.51 microg/ml.
CL-K1-/- mice revealed decreased phagocytosis of Streptococcus pneumoniae
intrarenal expression of COLEC11 rapidly increases in the postischemic period and colocalizes with complement deposited along the basolateral surface of the proximal renal tubule in association with L-fucose, the potential binding ligand for COLEC11.
identify collectin (zeige MBL2 Antikörper) CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK
This profile of CL-K1 expression is unique among the collectins. [CL-K1]
This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
collectin sub-family member 11
, collectin kidney protein 1
, collectin 2