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The protein encoded by CDCP1 is a transmembrane protein containing three extracellular CUB domains. Zusätzlich bieten wir Ihnen CUB Domain Containing Protein 1 Antikörper (184) und CUB Domain Containing Protein 1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.
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Human CDCP1 Protein expressed in HEK-293 Cells - ABIN2713643
Sandercock, Rust, Guillard, Sachsenmeier, Holoweckyj, Hay, Flynn, Huang, Yan, Herpers, Price, Soden, Freeth, Jermutus, Hollingsworth, Minter: Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling. in Molecular cancer 2015
These studies have important implications for the development of a therapeutic to block CDCP1 activity and Triple-negative breast cancer (TNBC)metastasis.
CDCP1 may facilitate loss of adhesion by promoting activation of EGFR (zeige EGFR Proteine) and Src (zeige SRC Proteine) at sites of cell-cell and cell-substratum contact.
Stromal expression patterns for both ADAM12 (zeige ADAM12 Proteine) and CDCP1.
these data demonstrated that HIF-2alpha (zeige EPAS1 Proteine) could promote hepatocellular carcinoma cell migration by regulating CDCP1
Our results establish that differential glycosylation, cell surface presentation and extracellular expression of CDCP1 are hallmarks of prostate cancer progression.
High CDCP1 expression is associated with Colorectal Cancer.
ADAM9 (zeige ADAM9 Proteine) enhances CDCP1 protein expression by suppressing miR (zeige MLXIP Proteine)-218 for lung tumor metastasis
Elevated CDCP1 was observed in 77% of HGSC cases. Silencing of CDCP1 reduced migration and non-adherent cell growth in vitro and tumour burden in vivo.
CDCP1 protein plays an important role in the progression of ovarian clear cell carcinoma. Elevated CDCP1 levels correlates with poor patient outcome in ovarian clear cell carcinoma patients.
CDCP1 overexpression enhances HER2 (zeige ERBB2 Proteine) activity. CDCP1 binds to HER2 (zeige ERBB2 Proteine), promoting SRC (zeige SRC Proteine)-HER2 (zeige ERBB2 Proteine) crosstalk.
Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor (zeige RYK Proteine) cross-talk in unanchored cells.
established mechanism for initiation of CDCP1-mediated signaling; demonstrated that processing of surface CDCP1 by extracellular serine proteases is prerequisite for CDCP1-dependent survival of cancer cells during metastasis; preventing cleavage of CDCP1 abrogated survival signaling associated with CDCP1 and induced PARP1 (zeige PARP1 Proteine) cleavage and PARP1 (zeige PARP1 Proteine)-mediated apoptosis
CDCP1 may have a role in neoplasm metastasis; targeting it with a monoclonal antibody inhibits metastasis in a prostate cancer model
The protein encoded by this gene is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
CUB domain-containing protein 1
, membrane glycoprotein gp140
, subtractive immunization M plus HEp3-associated 135 kDa protein
, transmembrane and associated with src kinases