C-Type Lectin Domain Family 4, Member E Proteine (CLEC4E)

CLEC4E encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Zusätzlich bieten wir Ihnen CLEC4E Antikörper (63) und CLEC4E Kits (16) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CLEC4E 26253 Q9ULY5
CLEC4E 56619 Q9R0Q8
Ratte CLEC4E CLEC4E 450223 Q67EQ1
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Top CLEC4E Proteine auf antikoerper-online.de

Showing 7 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
Details
HOST_Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
392,86 €
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HOST_Human Cells Rhesusaffen Fc Tag,ECD 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
650,00 €
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HOST_Human Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
214,29 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details

CLEC4E Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , ,
Mouse (Murine)
,

Am meisten referenzierte CLEC4E Proteine

  1. Human CLEC4E Protein expressed in HEK-293 Cells - ABIN2712869 : Wevers, Kaptein, Zijlstra-Willems, Theelen, Boekhout, Geijtenbeek, Gringhuis: Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity. in Cell host & microbe 2014 (PubMed)

Weitere Proteine zu C-Type Lectin Domain Family 4, Member E (CLEC4E) Interaktionspartnern

Human C-Type Lectin Domain Family 4, Member E (CLEC4E) Interaktionspartner

  1. combination adjuvant systems demonstrate markedly different immune activation with age, with combined DC activation via Macrophage-inducible C-type lectin and TLR7 (zeige TLR7 Proteine)/8 representing a novel approach to enhance the efficacy of early-life vaccines.

  2. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia

  3. a nonredundant role for Clec4e in coordinating major biological pathways involved in atherosclerosis

  4. CLEC4E expression is significantly upregulated in human masticatory mucosa during wound healing

  5. The expression of Mincle increases significantly during the early period of Aspergillus fumigatus infection, while expression of eight corresponding cytokines changes. Mincle, as a pattern recognition receptor, may play a role in the early innate immune response of the corneal resistance against fungus.

  6. Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy.

  7. our findings identify mincle as a contributor to the inflammatory response after traumatic brain injury

  8. Data indicate that MINCLE receptor is able to mediate the response to trehalose-6,6-dimycolate (TDM) dependent on SYK (zeige SYK Proteine) kinase and CARD9 (zeige CARD9 Proteine) protein.

  9. mincle is a fungal receptor that can suppress antifungal immunity and, as such, is a potential therapeutic target.

  10. These results demonstrated that GroMM is a unique ligand for human Mincle that is not recognized by mouse Mincle.

Mouse (Murine) C-Type Lectin Domain Family 4, Member E (CLEC4E) Interaktionspartner

  1. work implicates a novel innate immune driver of Con (zeige KITLG Proteine) A hepatitis and, more broadly, suggests a potential role for Mincle in diseases governed by sterile inflammation.

  2. Mincle deletion results in TLR4 (zeige TLR4 Proteine)-mediated inflammation.

  3. Priming by Mincle-deficient dendritic cells (DCs).

  4. Thus, macrophage activation by the corynebacterial cell wall relies on TLR2-driven robust Mincle expression and the cooperative action of both receptors.

  5. this study shows that immune activation in vitro and in vivo by trehalose esters of simple fatty acids requires two acyl chains of length and involves Mincle

  6. Attenuated neutrophil extracellular trap formation in Mincle-/- neutrophils correlates with impaired autophagy activation in vitro and in vivo, whereas reactive oxygen species formation in these neutrophils remained intact.

  7. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia

  8. this study shows a significant role for Mincle in Pneumocystis modulating host defense during infection

  9. The authors report that microbial stimulation triggers Mincle (Clec4e) expression through the myeloid differentiation primary response gene 88 (MyD88 (zeige MYD88 Proteine)) pathway; a process that does not require MCL (Clecsf8 (zeige CLEC4D Proteine), Clec4d (zeige CLEC4D Proteine)). Conversely, they show that MCL (zeige CLEC4D Proteine) is constitutively expressed but retained intracellularly until Mincle is induced, whereupon the receptors form heterodimers which are translocated to the cell surface.

  10. a nonredundant role for Clec4e in coordinating major biological pathways involved in atherosclerosis

Cow (Bovine) C-Type Lectin Domain Family 4, Member E (CLEC4E) Interaktionspartner

  1. The structure of an extended portion of the extracellular domain of mincle, beyond the minimal C-type carbohydrate recognition domain, also constrains the way the binding domains may interact on the surface of macrophages.

  2. The data demonstrate how mincle bridges between the surfaces of the macrophage and the mycobacterium.

Guinea Pig C-Type Lectin Domain Family 4, Member E (CLEC4E) Interaktionspartner

  1. the function of the guinea pig homologue of Mincle (gpMincle) and MCL (zeige CLEC4D Proteine) (gpMCL). gpMincle directly bound to trehalose-6,6'-dimycolate

CLEC4E Protein Überblick

Protein Überblick

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Genbezeichner und Symbole assoziert mit CLEC4E

  • C-type lectin domain family 4, member E (CLEC4E)
  • C-type lectin domain family 4, member e (Clec4e)
  • C-type lectin domain family 4, member E (Clec4e)
  • C-type lectin domain family 4, member E (LOC100350649)
  • C86253 Protein
  • CLEC4E Protein
  • Clecsf9 Protein
  • Mincle Protein

Bezeichner auf Proteinebene für CLEC4E

C-type lectin domain family 4, member E , C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 , C-type lectin domain family 4 member E , C-type lectin superfamily member 9 , macrophage-inducible C-type lectin , C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , C-type lectin, superfamily member 9 , immunoreceptor

GENE ID SPEZIES
611538 Canis lupus familiaris
722250 Macaca mulatta
735637 Pan troglodytes
100135686 Ovis aries
26253 Homo sapiens
56619 Mus musculus
450223 Rattus norvegicus
514797 Bos taurus
100350649 Oryctolagus cuniculus
100726838 Cavia porcellus
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